Daniel I. Feig
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View article: Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis
Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis Open
Introduction Preterm infants are at increased risk for hypertension due to incomplete organ development. With no established guidelines for treating hypertension in this population, clinicians rely on their experience, and little is known …
View article: Perinatal Urinary Tract Dilation: Recommendations on Pre-/Postnatal Imaging, Prophylactic Antibiotics, and Follow-up: Clinical Report
Perinatal Urinary Tract Dilation: Recommendations on Pre-/Postnatal Imaging, Prophylactic Antibiotics, and Follow-up: Clinical Report Open
Perinatal urinary tract dilation (UTD) occurs in approximately 1% of all pregnancies and represents the second most common congenital anomaly detected prenatally, second only to cardiac defects. Causes of UTD include transient dilation, ve…
View article: Sequence of antihypertensive medications used in preterm infants with hypertension: A cross-sectional study
Sequence of antihypertensive medications used in preterm infants with hypertension: A cross-sectional study Open
Background Hypertension in preterm infants can result in life-threatening outcomes. However, there is limited evidence to guide the pharmacologic management of hypertension in preterm infants. Without population-level studies of the pharma…
View article: Sugar, salt, immunity and the cause of primary hypertension
Sugar, salt, immunity and the cause of primary hypertension Open
Despite its discovery more than 150 years ago, the cause of primary hypertension remains unknown. Most studies suggest that hypertension involves genetic, congenital or acquired risk factors that result in a relative inability of the kidne…
View article: Trends in Blood Pressure and Hypertension Among US Children and Adolescents, 1999-2018
Trends in Blood Pressure and Hypertension Among US Children and Adolescents, 1999-2018 Open
Despite an overall decline in mean SBP and DBP from 1999-2002 to 2015-2018, BP levels among children and adolescents may have increased from 2011-2014 to 2015-2018.
View article: Hyperuricemia and abnormal nocturnal dipping impact glomerular filtration rate in patients with sickle cell anemia
Hyperuricemia and abnormal nocturnal dipping impact glomerular filtration rate in patients with sickle cell anemia Open
Patients with sickle cell anemia (SCA) are at increased risk for developing chronic kidney disease (CKD), and progression to end-stage renal disease is associated with increased morbidity and mortality. Identifying modifiable risk factors …
View article: Uric Acid and Hypertension: An Update With Recommendations
Uric Acid and Hypertension: An Update With Recommendations Open
The association between increased serum urate and hypertension has been a subject of intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones, and possibly vascular calcification. Mendelian randomizat…
View article: A Pilot Study Comparing Uric Acid and Biomarkers of Renal Injury and Inflammation in Pediatric Sickle Cell Disease at Vaso-Occlusive Crisis and Steady State
A Pilot Study Comparing Uric Acid and Biomarkers of Renal Injury and Inflammation in Pediatric Sickle Cell Disease at Vaso-Occlusive Crisis and Steady State Open
Hyperuricemia hastens the decline of renal function in chronic kidney disease and activates the pro-inflammatory Nlrp3 inflammasome. Studies from the 1970s posited that high rates of hyperuricemia seen in sickle cell anemia (SCA) patients …
View article: CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients
CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients Open
Background Optimal management of immunosuppression in kidney transplantation requires a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are significantly impacted by genetic variation in CYP3A5 polymorphisms, …
View article: Cytomegalovirus and Epstein‐Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis
Cytomegalovirus and Epstein‐Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis Open
Background CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal tra…
View article: Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy
Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy Open
Background In patients with diabetes mellitus, hyperfiltration precedes the development of albuminuria. Pediatric sickle cell anemia (SCA) patients have a high prevalence of hyperfiltration and albuminuria during early childhood and adoles…
View article: Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature
Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature Open
Overall, RTX effectively reduced the number of hospital admissions and oral CS burden. RTX also helped most all children achieve clinical remission. RTX appears to be an effective and safe alternative for chronic CS dependent and immunomod…
View article: Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantation
Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantation Open
The implementation of surveillance biopsies in pediatric kidney transplantation remains controversial. Surveillance biopsies detect subclinical injury prior to clinical dysfunction, which could allow for early interventions that prolong al…
View article: Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo‐Controlled Study
Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo‐Controlled Study Open
Background Hyperuricemia is associated with hypertension, with elevated serum uric acid levels postulated to have a causal role in the development of hypertension. Consequently, serum uric acid reduction may help lower blood pressure ( BP …