Daniel Irimia
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View article: Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation
Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation Open
The acute inflammatory response is a highly coordinated protective process governed by a superfamily of mediators termed specialized proresolving mediators. This includes the recently uncovered 17R-Resolvin D2 (17R-RvD2). We report 17R-RvD…
<i>Porphyromonas gingivalis</i> sphingolipids impair neutrophil function and promote bacterial survival Open
Our data suggest that SL synthesis is an efficient immune evasion mechanism of P. gingivalis, which dampens the inflammatory response of neutrophils to this endogenous pathogen.
Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients using a microfluidic assay Open
Long COVID (LC) impacts one in five children after an acute SARS-CoV-2 infection. Typical LC symptoms include fatigue, brain fog, pain, and shortness of breath, which can significantly impact individuals and society. Moreover, LC may impai…
View article: Monocyte Anisocytosis Can Discriminate Between Sepsis and Sterile Inflammation, but not Mortality, in Critically Ill Surgical/Trauma Patients: A Secondary Prospective Analysis
Monocyte Anisocytosis Can Discriminate Between Sepsis and Sterile Inflammation, but not Mortality, in Critically Ill Surgical/Trauma Patients: A Secondary Prospective Analysis Open
OBJECTIVES (BACKGROUND): Monocyte anisocytosis (monocyte distribution width [MDW]) has been previously validated to predict sepsis and outcome in patients presenting in the emergency department and mixed-population ICUs. Determining sepsis…
Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibility Open
Summary Malaria caused by Plasmodium falciparum ( Pf ) compromise innate immunity, yet the underlying mechanisms remain elusive. The immune dysregulation caused by the parasite may lead to bacterial superinfections and increase mortality. …
View article: 586 Monitoring Monocyte Anisocytosis Changes in Adult and Pediatric Burn Patients
586 Monitoring Monocyte Anisocytosis Changes in Adult and Pediatric Burn Patients Open
Introduction Burn injuries trigger pathological immune responses. However, our ability to monitor these evolving responses is constrained by the intricate confluence of cellular, biochemical, and metabolic alterations that occur concurrent…
View article: Resolvin <scp>D2</scp> restores monocyte anisocytosis and mediates a shift toward classical monocytes ex vivo in blood samples from patients after major burns
Resolvin <span>D2</span> restores monocyte anisocytosis and mediates a shift toward classical monocytes ex vivo in blood samples from patients after major burns Open
Circulating monocytes contribute to the defense against pathogens and play a crucial role in maintaining immune homeostasis. While there is substantial evidence regarding the triggers of monocyte activation, our understanding of how monocy…
Pseudomonas aeruginosa aggregates elicit neutrophil swarming Open
Pseudomonas aeruginosa, a gram-negative multidrug-resistant (MDR) opportunist, belongs to the ESKAPE group of pathogens associated with the highest risk of mortality. Neutrophil swarming is a host defense strategy triggered by larger threa…
Neutrophil extracellular traps capture the human pathogen, <i>Candida albicans,</i> in blood and delay hyphal transformation Open
In tissues, neutrophils neutralize Candida albicans through phagocytosis and delay C. albicans hyphae growth by deploying neutrophil extracellular traps (NETs). However, in the bloodstream, the dynamic interactions between NETs and C. albi…
Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions Open
Neutrophils communicate with one another and amplify their destructive power through swarming, a collective process that synchronizes the activities of multiple neutrophils against one target. The sequence of activities contributing to swa…
Neutrophil swarming is crucial for limiting oral mucosal infection by <i>Candida albicans</i> Open
Oral mucosal colonization by Candida albicans is benign in healthy people but progresses to deeper infection, known as oropharyngeal candidiasis, that may become disseminated when combined with immunosuppression. Cortisone use and neutrope…
MONOCYTE ANISOCYTOSIS IS ASSOCIATED WITH SEPSIS IN CHILDREN WITH SUSPECTED INFECTION Open
Background: Early, accurate determination of disease severity in an emergency setting is paramount for improving patient outcomes and healthcare costs. Monocyte anisocytosis, quantified as monocyte distribution width (MDW), has been shown …
Gene expression-phenotype association study reveals the dual role of TNF-α/TNFR1 signaling axis in confined breast cancer cell migration Open
TNF-α/TNFR1 signaling axis reveals as a key player in driving BC cells confined migration, emerging as a promising therapeutic strategy in targeting dissemination and metastasis of triple negative, mesenchymal BC cells.
View article: Monocyte Anisocytosis Changes in Patients After Major Burn Injuries
Monocyte Anisocytosis Changes in Patients After Major Burn Injuries Open
The recovery of patients after severe burns is a long and complex process. Genomic analysis of white blood cells from burn and trauma patients revealed excessive and prolonged innate immune activation in patients with complicated outcomes.…
BTK inhibitor–induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α Open
Inhibition of Bruton's tyrosine kinase (BTK) through covalent modifications of its active site (e.g., ibrutinib [IBT]) is a preferred treatment for multiple B cell malignancies. However, IBT-treated patients are more susceptible to invasiv…
12 Monitoring Monocyte Anisocytosis Changes as a Burn Injury Recovery Marker: Insights from a Clinical Study Open
Introduction Severe burn injuries trigger pathological immune responses. However, our ability to monitor these evolving responses is constrained by the intricate confluence of cellular, biochemical, and metabolic alterations that occur con…
Gene expression-phenotype association study reveals the dual role of TNF- α/TNFR1 signaling axis in confined breast cancer cell migration Open
While enhanced tumor cell migration is a key process in the tumor disemination, mechanistic insights into causal relationships between tumor cells and mechanical confinement are still limited. Here we combine the use of microfluidic platfo…
View article: Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming
Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming Open
Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an ex vivo model of infection, we find that human neutrophils u…
Monocyte anisocytosis corresponds with increasing severity of COVID-19 in children Open
Introduction Although SARS-CoV-2 infection can lead to severe COVID-19 in children, the role of biomarkers for assessing the risk of progression to severe disease is not well established in the pediatric population. Given the differences i…
View article: <i>Fusobacterium nucleatum</i> dissemination by neutrophils
<i>Fusobacterium nucleatum</i> dissemination by neutrophils Open
Recent studies uncovered that Fusobacterium nucleatum (Fn), a common, opportunistic bacterium in the oral cavity, is associated with a growing number of systemic diseases, ranging from colon cancer to Alzheimer's disease. However, the path…
View article: Microfluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration
Microfluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration Open
Cancer cells that migrate from tumors into surrounding tissues are responsible for cancer dissemination through the body. Microfluidic devices have been instrumental in discovering unexpected features of cancer cell migration, including th…
View article: Megakaryocytes respond during sepsis and display innate immune cell behaviors
Megakaryocytes respond during sepsis and display innate immune cell behaviors Open
Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to participate in immune responses and play significant functions during infections, the rol…