Daniel Ivansson
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View article: Stepwise activation of gene copies results in higher final titers of subclones compared to immediate integration of the full set of active copies
Stepwise activation of gene copies results in higher final titers of subclones compared to immediate integration of the full set of active copies Open
The increasing demand for production of therapeutic proteins has encouraged both industrial and academic institutions to pursue the development of mammalian expression platforms with high productivities. While protocols for rapid and effic…
View article: Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities
Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities Open
Chinese hamster ovary (CHO) cells produce a large share of today's biopharmaceuticals. Still, the generation of satisfactory producer cell lines is a tedious undertaking. Recently, it was found that CHO cells, when exposed to new environme…
View article: A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells
A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells Open
Manipulation of multiple genes to engineer Chinese Hamster Ovary (CHO) cells for better performance in production processes of biopharmaceuticals has recently become more and more popular. Yet, identification of useful genes and the unequi…