Daniel J. Parente
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View article: Food Insecurity Is Associated with Vitamin B12 Deficiency: The All of Us Database
Food Insecurity Is Associated with Vitamin B12 Deficiency: The All of Us Database Open
Vitamin B12 deficiency is associated with food insecurity in United States adults enrolled in the NIH All of Us database. Future analyses designed to infer causality are warranted.
View article: Leveraging the All of Us Database for Primary Care Research with Large Datasets
Leveraging the All of Us Database for Primary Care Research with Large Datasets Open
The National Institutes of Health (NIH) are supporting the All of Us research program, a large multicenter initiative to accelerate precision medicine. The All of Us database contains information on greater than 400,000 individuals spannin…
View article: Local Health Equity Action Teams (LHEATS) as a Novel and Emerging Practice of the Communities Organizing to Promote Equity (COPE) Project in Kansas
Local Health Equity Action Teams (LHEATS) as a Novel and Emerging Practice of the Communities Organizing to Promote Equity (COPE) Project in Kansas Open
The Communities Organizing to Promote Equity (COPE) Project was implemented in 20 counties across Kansas to build capacity to address health equity by forming local health equity action teams (LHEATS), hiring and training community health …
View article: Generative Artificial Intelligence and Large Language Models in Primary Care Medical Education
Generative Artificial Intelligence and Large Language Models in Primary Care Medical Education Open
Generative artificial intelligence and large language models are the continuation of a technological revolution in information processing that began with the invention of the transistor in 1947. These technologies, driven by transformer ar…
View article: Family Medicine Must Prepare for Artificial Intelligence
Family Medicine Must Prepare for Artificial Intelligence Open
Artificial Intelligence (AI) is poised to revolutionize family medicine, offering a transformative approach to achieving the Quintuple Aim. This article examines the imperative for family medicine to adapt to the rapidly evolving field of …
View article: Communities organizing to promote equity: engaging local communities in public health responses to health inequities exacerbated by COVID-19–protocol paper
Communities organizing to promote equity: engaging local communities in public health responses to health inequities exacerbated by COVID-19–protocol paper Open
Background The COVID-19 pandemic has disproportionately impacted rural and under-resourced urban communities in Kansas. The state’s response to COVID-19 has relied on a highly decentralized and underfunded public health system, with 100 lo…
View article: Quality, Accuracy, and Bias in ChatGPT-Based Summarization of Medical Abstracts
Quality, Accuracy, and Bias in ChatGPT-Based Summarization of Medical Abstracts Open
Summaries generated by ChatGPT were 70% shorter than mean abstract length and were characterized by high quality, high accuracy, and low bias. Conversely, ChatGPT had modest ability to classify the relevance of articles to medical specialt…
View article: Communities Organizing to Promote Equity (COPE): Engaging local communities in public health responses to health inequities exacerbated by COVID-19– Protocol Paper
Communities Organizing to Promote Equity (COPE): Engaging local communities in public health responses to health inequities exacerbated by COVID-19– Protocol Paper Open
Background The COVID-19 pandemic has disproportionately impacted rural and under-resourced urban communities in Kansas. The state's response to COVID-19 has relied on a highly decentralized and underfunded public health system, with 100 lo…
View article: Perceived Value of Public Health and Health Policy Information Among Medical Students: A Cross-sectional Study
Perceived Value of Public Health and Health Policy Information Among Medical Students: A Cross-sectional Study Open
Introduction: Health educators have had difficulty introducing health policy and public health training into an already intensive medical school curriculum. Although the COVID-19 pandemic may have changed perspectives on the importance of …
View article: More Than Half of Family Medicine Clerkships Do Not Address Systemic Racism: A CERA Study
More Than Half of Family Medicine Clerkships Do Not Address Systemic Racism: A CERA Study Open
Background and Objectives: The influence of racism in medicine is increasingly acknowledged, and the negative effect of systemic racism on individual and population health is well established. Yet, little is known about how or whether medi…
View article: Critical gaps in knowledge and implementation of recommendations by the US Preventive Services Task Force
Critical gaps in knowledge and implementation of recommendations by the US Preventive Services Task Force Open
Critical gaps exist in resident knowledge and implementation of USPSTF recommendations. We discuss urgent implications for cancer prevention, public health, and health equity.
View article: Adaptation and External Validation of Pathogenic Urine Culture Prediction in Primary Care Using Machine Learning
Adaptation and External Validation of Pathogenic Urine Culture Prediction in Primary Care Using Machine Learning Open
The NoMicro classifier appears appropriate for PC. Prospective trials to adjudicate the balance of benefits and harms of using the NoMicro classifier are appropriate.
View article: PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes
PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes Open
Interpreting changes in patient genomes, understanding how viruses evolve and engineering novel protein function all depend on accurately predicting the functional outcomes that arise from amino acid substitutions. To that end, the develop…
View article: Assessing Social Needs and Engaging Community Health Workers in Underserved Kansas Counties: Insights From Primary Care Providers and Clinic Managers
Assessing Social Needs and Engaging Community Health Workers in Underserved Kansas Counties: Insights From Primary Care Providers and Clinic Managers Open
Introduction: Rural and under-resourced urban communities face unique challenges in addressing patients’ social determinants of health needs (SDoH). Community health workers (CHWs) can support patients experiencing social needs, yet little…
View article: Machine Learning Prediction of Urine Cultures in Primary Care
Machine Learning Prediction of Urine Cultures in Primary Care Open
Context: Antibiotics for suspected urinary tract infection (UTI) is appropriate only when an infection is present. Urine culture is definitive but takes >1 day to result. A machine learning urine culture predictor was recently devised for …
View article: Impact of the COVID-19 Pandemic on Exercise Habits Among US Primary Care Patients
Impact of the COVID-19 Pandemic on Exercise Habits Among US Primary Care Patients Open
Most participants decreased physical activity during the unprecedented COVID-19 pandemic, expanding our understanding of how exercise habits change during stressful life events.
View article: Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation
Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation Open
When amino acids vary during evolution, the outcome can be functionally neutral or biologically‐important. We previously found that substituting a subset of nonconserved positions, “rheostat” positions, can have surprising effects on prote…
View article: Acceptance of COVID-19 Vaccination Among Health System Personnel
Acceptance of COVID-19 Vaccination Among Health System Personnel Open
Many HCP intend to delay or refuse COVID-19 vaccination. Policymakers should impartially address concerns about safety, efficacy, side effects, risk-to-benefit ratio, and cost. Further research with minority subgroups is urgently needed.
View article: “Multiplex” rheostat positions cluster around allosterically critical regions of the lactose repressor protein
“Multiplex” rheostat positions cluster around allosterically critical regions of the lactose repressor protein Open
Amino acid variation at “rheostat” positions provides opportunity to modulate various aspects of protein function – such as binding affinity or allosteric coupling – across a wide range. Previously a subclass of “multiplex” rheostat positi…
View article: BRCA-Related Cancer Genetic Counseling is Indicated in Many Women Seeking Primary Care
BRCA-Related Cancer Genetic Counseling is Indicated in Many Women Seeking Primary Care Open
The rate that undifferentiated women seeking primary care met 2019 USPSTF criteria for BRCA-related cancer genetic counseling referral (24.4% ± 4.2%) exceeds earlier estimates (4 to 5%) but agrees with later, population-level estimates (24…
View article: Identification of biochemically neutral positions in liver pyruvate kinase
Identification of biochemically neutral positions in liver pyruvate kinase Open
Understanding how each residue position contributes to protein function has been a long‐standing goal in protein science. Substitution studies have historically focused on conserved protein positions. However, substitutions of nonconserved…
View article: Identification of biochemically neutral positions in liver pyruvate kinase
Identification of biochemically neutral positions in liver pyruvate kinase Open
Understanding how each residue position contributes to protein function has been a long-standing goal in protein science. Substitution studies have historically focused on conserved protein positions. However, substitutions of nonconserved…
View article: Development of an experimental unit for studying the solar drying process
Development of an experimental unit for studying the solar drying process Open
The removal of moisture by drying, prevents the growth and reproduction of these microorganisms, which cause rotting, and minimizes many of the reactions of deterioration from moisture, revealing itself a crucial preservation method. Portu…