Daniel J. Tschumperlin
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View article: Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues
Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues Open
Lung fibroblasts generate and respond to mechanical, biochemical, and matrix cues present in their microenvironment. With the advent of next-generation sequencing technologies, multiple studies describe transcriptionally unique fibroblast …
View article: Optimized Synthetic Flavonols Support Senescence Clearance and Lung Fibrosis Resolution
Optimized Synthetic Flavonols Support Senescence Clearance and Lung Fibrosis Resolution Open
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with undefined etiology and minimally effective therapies. The greatest risk factor for developing IPF is aging. The central paradigm to developing antifibrotic drugs f…
View article: Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer Open
Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despite solid in vitro evidence, its role in vivo remains largely speculative. Here we demonstrate that durotaxis actively …
View article: Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis
Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis Open
This study demonstrates that circulating extracellular vesicles (cEVs) isolated from young mice reverse the transcriptional alterations of the aged mouse pulmonary vasculature, leading to a more youthful endothelial transcriptional phenoty…
View article: Abstract 2130 Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis
Abstract 2130 Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis Open
View article: Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure Open
Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics technologies have begun revolutionizing our unde…
View article: SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis
SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis Open
View article: Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK
Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK Open
Pre-cancerous lung lesions are commonly initiated by activating mutations in the RAS pathway, but do not transition to lung adenocarcinomas (LUAD) without additional oncogenic signals. Here, we show that expression of the extracellular mat…
View article: Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis
Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis Open
Fibrosis in the lung is thought to be driven by epithelial cell dysfunction and aberrant cell-cell interactions. Unveiling the molecular mechanisms of cellular plasticity and cell-cell interactions is imperative to elucidating lung regener…
View article: A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung
A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung Open
Idiopathic pulmonary fibrosis (IPF) is an aggressive and, thus far, incurable disease characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease etiology is incomplete; however, there is…
View article: <scp>RNA</scp>‐sequencing reveals differential fibroblast responses to bleomycin and pneumonectomy
<span>RNA</span>‐sequencing reveals differential fibroblast responses to bleomycin and pneumonectomy Open
Pulmonary fibrosis is characterized by pathological accumulation of scar tissue in the lung parenchyma. Many of the processes that are implicated in fibrosis, including increased extracellular matrix synthesis, also occur following pneumon…
View article: Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023
Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023 Open
Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence from preclinical mode…
View article: Non‐canonical <scp>IKB</scp> kinases regulate <scp>YAP</scp>/<scp>TAZ</scp> and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells
Non‐canonical <span>IKB</span> kinases regulate <span>YAP</span>/<span>TAZ</span> and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells Open
Pulmonary arterial hypertension (PAH) causes pulmonary vascular remodeling, increasing pulmonary vascular resistance (PVR) and leading to right heart failure and death. Matrix stiffening early in the disease promotes remodeling in pulmonar…
View article: SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis
SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 am…
View article: Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis
Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Open
View article: SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis
SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 am…
View article: Defining signals that promote human alveolar type I differentiation
Defining signals that promote human alveolar type I differentiation Open
Alveolar type I (ATI) epithelial cells perform essential roles in maintaining lung function but have been challenging to study. We explored the signals that promote ATI fate in 3-D organoid cultures generated from either mixed distal human…
View article: Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis
Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis Open
BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to …
View article: A redox-shifted fibroblast subpopulation emerges in the fibrotic lung
A redox-shifted fibroblast subpopulation emerges in the fibrotic lung Open
Idiopathic pulmonary fibrosis (IPF) is an aggressive and thus far incurable disease, characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease etiology is incomplete; however, there is …
View article: Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade
Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade Open
The neutral amino acid glutamine plays a central role in TGF-β (transforming growth factor-β)-induced myofibroblast activation and differentiation. Cells take up glutamine mainly through a transporter expressed on the cell surface known as…
View article: Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts
Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts Open
View article: Atomic Force Microscopy Micro-Indentation Methods for Determining the Elastic Modulus of Murine Articular Cartilage
Atomic Force Microscopy Micro-Indentation Methods for Determining the Elastic Modulus of Murine Articular Cartilage Open
The mechanical properties of biological tissues influence their function and can predict degenerative conditions before gross histological or physiological changes are detectable. This is especially true for structural tissues such as arti…
View article: The matricellular protein CCN3 supports lung endothelial homeostasis and function
The matricellular protein CCN3 supports lung endothelial homeostasis and function Open
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations, and increased vas…
View article: RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblasts
RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblasts Open
Background Idiopathic pulmonary fibrosis (IPF) is characterized by pathological accumulation of scar tissue in the lung parenchyma. Many of the processes that are implicated in fibrosis, such as matrix deposition also occur following pneum…
View article: Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis
Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis Open
View article: Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis
Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis Open
View article: Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis
Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis Open
Background During liver injury, liver sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote liver fibrosis. We have previously reported that the LSEC vascular cell adhesion molecule 1 (VCAM1) plays a key role in live…
View article: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis
Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis Open
View article: Targeting Pulmonary Fibrosis by SLC1A5 dependent Glutamine Transport Blockade
Targeting Pulmonary Fibrosis by SLC1A5 dependent Glutamine Transport Blockade Open
The neutral amino acid glutamine plays a central role in TGF-β-induced myofibroblast activation and differentiation. Cells take up glutamine mainly through a transporter expressed on the cell surface known as solute carrier SLC1A5. In this…
View article: 324 The role of CCN3 in lung endothelial identity and function
324 The role of CCN3 in lung endothelial identity and function Open
OBJECTIVES/GOALS: Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease of lung scarring. Aberrant vascular remodeling is a contributor to IPF progression. We have identified CCN3 as an endothelial gene that is upregulated in resolving bu…