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View article: WITHDRAWN: Resistance exercise-induced skeletal muscle damage is mitigated by adaptation-dependent changes in protein localization and phosphorylation
WITHDRAWN: Resistance exercise-induced skeletal muscle damage is mitigated by adaptation-dependent changes in protein localization and phosphorylation Open
The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
View article: WITHDRAWN: Resistance exercise-induced skeletal muscle damage is mitigated by adaptation-dependent changes in protein localization and phosphorylation
WITHDRAWN: Resistance exercise-induced skeletal muscle damage is mitigated by adaptation-dependent changes in protein localization and phosphorylation Open
Resistance exercise (RE) improves strength and muscle mass but concomitantly inflicts myofibrillar damage, necessitating efficient proteostatic restoration. The signaling and proteostatic processes distinguishing damaged and intact areas a…
View article: Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage
Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage Open
Desmin intermediate filaments play a crucial role in stress transmission and mechano-protection. The loss of its integrity triggers myofibril breakdown and muscle atrophy for which desmin phosphorylation ( p Des) is a priming factor. We in…
View article: Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic
Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic Open
Proteome maintenance in contracting skeletal and cardiac muscles depends on the chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and heart failure in animal models and patients. BAG3 and its chaperone partn…
View article: microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism
microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism Open
MicroRNA-1 (miR-1) is the most abundant miRNA in adult skeletal muscle. To determine the function of miR-1 in adult skeletal muscle, we generated an inducible, skeletal muscle-specific miR-1 knockout (KO) mouse. Integration of RNA-sequenci…
View article: Increased resting lactate levels and reduced carbohydrate intake cause νLa.max underestimation by reducing net lactate accumulation—A pilot study in young adults
Increased resting lactate levels and reduced carbohydrate intake cause νLa.max underestimation by reducing net lactate accumulation—A pilot study in young adults Open
Modulation of testing conditions such as resting lactate (La rest ) levels or carbohydrate intake may affect the calculation of the maximal glycolytic rate (νLa.max). To evaluate the impact of elevated La rest as well as reduced and increa…
View article: Acute exercise activates the AHR in peripheral blood mononuclear cells in an intensity-dependent manner
Acute exercise activates the AHR in peripheral blood mononuclear cells in an intensity-dependent manner Open
The findings of this study show that acute endurance exercise activates a receptor that has been described to integrate metabolic signals into the immune system. We uncover a potential mechanistic link on how exercise modulates the immune …
View article: Desmin Phosphorylation in human skeletal muscle can be modified by Resistance Exercise rendering the protein less vulnerable to protease-dependent cleavage
Desmin Phosphorylation in human skeletal muscle can be modified by Resistance Exercise rendering the protein less vulnerable to protease-dependent cleavage Open
The desmin intermediate filament (IF) system plays a crucial role in stress transmission, mechano-protection, and the regulation of signaling in skeletal muscle. Loss of IF integrity is considered a triggering factor for myofibril breakdow…
View article: Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men
Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men Open
Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF‐formation. Resistance training (RT) improves muscle …
View article: Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs
Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs Open
The kynurenine pathway of tryptophan degradation generates several metabolites such as kynurenine or kynurenic acid that serve as endogenous ligands of the aryl hydrocarbon receptor (AHR). Due to its distinct biological roles particularly …
View article: Resistance exercise: a mighty tool that adapts, destroys, rebuilds and modulates the molecular and structural environment of skeletal muscle
Resistance exercise: a mighty tool that adapts, destroys, rebuilds and modulates the molecular and structural environment of skeletal muscle Open
[Purpose] Skeletal muscle regulates health and performance by maintaining or increasing strength and muscle mass. Although the molecular mechanisms in response to resistance exercise (RE) significantly target the activation of protein synt…
View article: Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome
Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome Open
Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits are largely unknown. Aim: To investigate how acute RE affects human ske…
View article: Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers
Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers Open
The acute resistance exercise (RE)-induced phosphorylation of mTOR-related signaling proteins in skeletal muscle can be blunted after repeated RE. The time frame in which the phosphorylation (p) of mTORS2448, p70S6kT421/S424, and rpS6S235/…
View article: Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome
Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome Open
Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits is largely unknown. Aim: To investigate how acute RE affects human skel…
View article: PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle
PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle Open
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its …
View article: Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle Open
Skeletal muscle is a target of contraction-induced loading (CiL), leading to protein unfolding or cellular perturbations, respectively. While cytoskeletal desmin is responsible for ongoing structural stabilization, in the immediate respons…
View article: Phosphorylation of αB-crystallin and its cytoskeleton association differs in skeletal myofiber types depending on resistance exercise intensity and volume
Phosphorylation of αB-crystallin and its cytoskeleton association differs in skeletal myofiber types depending on resistance exercise intensity and volume Open
αB-crystallin (CRYAB) is an important actor in the immediate cell stabilizing response following mechanical stress in skeletal muscle. Yet, only little is known regarding myofiber type-specific stress responses of CRYAB. We investigated wh…
View article: Suppl data Gehlert RT metabolome.xlsx
Suppl data Gehlert RT metabolome.xlsx Open
Metabolomic analysis of human skeletal muscle after acute and prolonged resistance exercise.
View article: Suppl data Gehlert RT metabolome.xlsx
Suppl data Gehlert RT metabolome.xlsx Open
Metabolomic analysis of human skeletal muscle after acute and prolonged resistance exercise.
View article: Resistance exercise-induced muscle fatigue is not accompanied by increased phosphorylation of ryanodine receptor 1 at serine 2843
Resistance exercise-induced muscle fatigue is not accompanied by increased phosphorylation of ryanodine receptor 1 at serine 2843 Open
Skeletal muscle fatigue has been shown to be associated with hyperphosphorylation of the ryanodine receptor 1 at serine 2843 (pRyR1Ser2843), due to chronic overloading exercise. We investigated whether pRyR1Ser2843, is a mechanism relevant…
View article: p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle
p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle Open
Exercise induces adaptation of skeletal muscle by acutely modulating intracellular signaling, gene expression, protein turnover and myogenic activation of skeletal muscle stem cells (Satellite cells, SCs). Lactate (La)-induced metabolic st…