Daniel J. Jackson
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View article: Human coronavirus HKU1 neutralization by glycan receptor mimicry
Human coronavirus HKU1 neutralization by glycan receptor mimicry Open
Summary Entry of seasonal human coronavirus HKU1 (HCoV-HKU1) into host cells is facilitated by sequential binding to sialoglycans and transmembrane serine protease 2 (TMPRSS2) receptors. However, the neutralizing capacity of antibodies dis…
View article: Dupilumab efficacy by disease severity in pediatric type 2 asthma
Dupilumab efficacy by disease severity in pediatric type 2 asthma Open
Background Dupilumab demonstrated efficacy in children with asthma in phase 3 VOYAGE (NCT02948959) and open‐label extension EXCURSION (NCT03560466) studies. This post hoc analysis assessed dupilumab's long‐term efficacy by asthma severity …
View article: Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments
Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments Open
Background Childhood-onset asthma is highly heritable, with nearly 200 risk loci identified in genome-wide association studies. Aggregated polygenic risk scores can be used to quantify genetic predisposition to asthma, but their power to p…
View article: COVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program
COVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program Open
Importance Studies suggest developmental concerns for infants born during the COVID-19 pandemic, but evidence on its impact on toddler behavioral and emotional well-being remains limited. Objective To assess whether birth timing relative t…
View article: Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma
Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma Open
View article: A prospective cohort study of pregnancy outcomes following antepartum infection with SARS-CoV-2
A prospective cohort study of pregnancy outcomes following antepartum infection with SARS-CoV-2 Open
View article: Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children
Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children Open
View article: Association of Area Deprivation Index with perinatal and COVID-19 outcomes during the early pandemic: a secondary analysis of a prospective cohort study
Association of Area Deprivation Index with perinatal and COVID-19 outcomes during the early pandemic: a secondary analysis of a prospective cohort study Open
Patients in the highest ADI group, therefore living in the most deprived neighborhoods, were more likely to experience extremely preterm birth, contract SARS-CoV-2 infection, and become hospitalized due to COVID-19. The interplay of social…
View article: The common cold is associated with protection from SARS-CoV-2 Infections
The common cold is associated with protection from SARS-CoV-2 Infections Open
Background Adults and children often respond differently to SARS-CoV-2 infection, with adults facing a higher risk of symptomatic and severe illness. We hypothesize that children's protection from symptomatic SARS-CoV-2 may be due to more …
View article: Genotypes in the 17q12‐q21 asthma risk locus and early‐life viral wheezing illnesses
Genotypes in the 17q12‐q21 asthma risk locus and early‐life viral wheezing illnesses Open
View article: Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility
Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility Open
View article: Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children Open
View article: Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort
Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort Open
Importance Inorganic arsenic is associated with adverse birth outcomes, but evidence is limited for public water concentrations (modifiable by federal regulatory action) in US populations. Objective To evaluate the association between pren…
View article: Phenotypes of Atopic Dermatitis and Development of Allergic Diseases
Phenotypes of Atopic Dermatitis and Development of Allergic Diseases Open
Importance Atopic dermatitis (AD) is the most common inflammatory disease in childhood, and children with AD are more likely to develop other allergic diseases, including food allergy, allergic rhinitis, and asthma. Objective To determine …
View article: OP0166 EFFICACY AND SAFETY OF TWO YEARS OF TREATMENT WITH ANTI-IL-5/R THERAPIES FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
OP0166 EFFICACY AND SAFETY OF TWO YEARS OF TREATMENT WITH ANTI-IL-5/R THERAPIES FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS Open
View article: Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years
Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years Open
Importance Higher blood pressure in early life may signal cardiovascular disease over the life course, but determinants of blood pressure in early life are poorly understood. Objective To examine the association of maternal cardiometabolic…
View article: A novel model to predict age of respiratory syncytial virus infection from birth timing in relation to RSV circulation
A novel model to predict age of respiratory syncytial virus infection from birth timing in relation to RSV circulation Open
Respiratory syncytial virus (RSV) is a common respiratory virus that infects all children by age 2 to 3 years of age and causes the greatest morbidity at the extremes of life. Recent evidence suggests that early-life RSV infection, defined…
View article: Once versus Twice Daily Iron Supplementation in Pregnancy
Once versus Twice Daily Iron Supplementation in Pregnancy Open
Purpose: Iron-deficiency anemia in pregnancy is generally defined by a hemoglobin concentration < 11 g/dL. It affects up to 25% of all pregnancies in the United States. Typically, pregnant women take iron supplements to improve iron status…
View article: Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort Open
Background Research suggests racial/ethnic disparities in prenatal exposure to endocrine disrupting environmental phenols (EPs) in limited populations. However, no studies have investigated racial/ethnic disparities in prenatal EP exposure…
View article: Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study
Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study Open
Study Objectives Research linking children’s sleep to cognitive outcomes is inconsistent and has largely focused on one aspect of sleep, such as duration, rather than measuring multiple dimensions of sleep health. We hypothesized that chil…
View article: Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO
Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO Open
Prenatal exposure to air pollution is an important risk factor for child health outcomes, including asthma. Identification of DNA methylation changes associated with air pollutant exposure can provide new intervention targets to improve ch…
View article: Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children
Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children Open
This was, to our knowledge, the first study showing that caregiver COVID-19 illness worry was predictive of both COVID-19 mitigation compliance and laboratory-determined household infection. Findings should inform studies weighing the adap…
View article: Prenatal Diet and Infant Growth From Birth to Age 24 Months
Prenatal Diet and Infant Growth From Birth to Age 24 Months Open
Importance Being born either small for gestational age (SGA) or large for gestational age (LGA) and experiencing rapid or slow growth after birth are associated with later-life obesity. Understanding the associations of dietary quality dur…
View article: Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children Open
Background Asthma is the most common chronic respiratory disease in children, but little is known about genetic contributions to its underlying endotypes. To address this gap, we studied the methylome, transcriptome, and genome from childr…
View article: Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype
Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype Open
Depemokimab reduced the annualized rate of exacerbations among patients with severe asthma with an eosinophilic phenotype. (Funded by GSK; SWIFT-1 and SWIFT-2 ClinicalTrials.gov numbers, NCT04719832 and NCT04718103.).
View article: Viral and non‐viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children
Viral and non‐viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children Open
Background Viral wheezing is an important risk factor for asthma, which comprises several respiratory phenotypes. We sought to understand if the etiology of early‐life wheezing illnesses relates to childhood respiratory and asthma phenotyp…
View article: Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium Open
Using pooled vaginal microbiota data from pregnancy cohorts (N = 683 participants) in the Environmental influences on Child Health Outcomes (ECHO) Program, we analyzed 16S rRNA gene amplicon sequences to identify clinical and demographic h…
View article: Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods
Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods Open
The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and househ…
View article: Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO
Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO Open
Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well‐…
View article: Viral and Non-viral Episodes of Wheezing in Early Life and the Development of Asthma and Respiratory Phenotypes Among Urban Children
Viral and Non-viral Episodes of Wheezing in Early Life and the Development of Asthma and Respiratory Phenotypes Among Urban Children Open
Background: Viral wheeze is an important risk factor for asthma, which comprises several respiratory phenotypes. We sought to understand if the etiology of early life wheezing illnesses relates to childhood respiratory and asthma phenotype…