Martijn Huisman
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View article: Bidirectional Associations Between End-of-Life Communication and Depressive Symptoms in Older Adults
Bidirectional Associations Between End-of-Life Communication and Depressive Symptoms in Older Adults Open
View article: Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping
Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping Open
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association study (GWAS) of DSM-defined lifetime Major Depressive Disorder (MDD) in…
View article: What Changes First? Mapping the Temporal Ordering of Age-related Functional Decline Across Domains Using 30-year Longitudinal Data
What Changes First? Mapping the Temporal Ordering of Age-related Functional Decline Across Domains Using 30-year Longitudinal Data Open
Introduction. Age-related functional decline is assumed to be a complex process in which declines in one domain may trigger decline in others. Yet research empirically identifying the temporal ordering of age-related decline across emotion…
View article: 8237928 Creating directed acyclic graphs (DAGs) with domain experts for healthy employment among aging workers
8237928 Creating directed acyclic graphs (DAGs) with domain experts for healthy employment among aging workers Open
View article: Two decades of end-of-life conditions of older adults: older and more protracted?
Two decades of end-of-life conditions of older adults: older and more protracted? Open
In non-cancer decedents, but not in cancer decedents, the dying process was more protracted in 2018 than in 2008. Level and increase in symptom severity did not improve over time for both cancer and non-cancer decedents, suggesting that im…
View article: Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool
Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool Open
A family history of fracture is confirmed as a significant BMD-independent predictor of future fracture risk. While parental hip fracture appears the strongest factor for future hip fracture, a family history of other fractures might be ap…
View article: The association between intrinsic capacity and functional ability in older adults – exploring the role of the physical environment
The association between intrinsic capacity and functional ability in older adults – exploring the role of the physical environment Open
Higher IC was related to less functional decline. Exposure to higher levels of PM10 appears to mitigate the protective association between IC and FA in older adults.
View article: A coordinated analysis of bidirectional associations between life satisfaction and cognitive function.
A coordinated analysis of bidirectional associations between life satisfaction and cognitive function. Open
Life satisfaction is an important component of well-being to consider in relation to cognitive function due to its modifiability, potential utility in public health policy, and associations with cognitive health outcomes. However, little i…
View article: Body mass index and subsequent fracture risk: a meta-analysis to update FRAX
Body mass index and subsequent fracture risk: a meta-analysis to update FRAX Open
The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 co…
View article: Temporal dynamics of perceived self-reliance and psychiatric symptoms in older adults: applying dynamic time warping to longitudinal cohort data
Temporal dynamics of perceived self-reliance and psychiatric symptoms in older adults: applying dynamic time warping to longitudinal cohort data Open
Within-person changes in self-reliance may have limited value as early warning signs for declining mental health, although in older adults who develop anxiety, declining mastery may signal worsening symptoms. Findings underscore the comple…
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: Smartphone-based detection of memory decline in prodromal Alzheimer’s disease
Smartphone-based detection of memory decline in prodromal Alzheimer’s disease Open
The slow progression of Alzheimer’s disease (AD) poses a challenge for the rapid and individual quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive …
View article: Increased Genetic Protection Against Alzheimer’s Disease in Centenarians
Increased Genetic Protection Against Alzheimer’s Disease in Centenarians Open
We constructed a polygenic protective score specific to Alzheimer’s disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longevity in the US, Europe, and Asia. This A…
View article: Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping
Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping Open
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder …
View article: The Longitudinal Aging Study Amsterdam: design and cohort update 2025
The Longitudinal Aging Study Amsterdam: design and cohort update 2025 Open
The Longitudinal Aging Study Amsterdam (LASA) is an ongoing prospective cohort study of older adults in the Netherlands, with data on multiple domains of functioning available over a period of more than 30 years of follow-up. The study sta…
View article: Lifestyle and cognition: Separating the effects of average lifestyle and lifestyle changes based on the LIBRA score
Lifestyle and cognition: Separating the effects of average lifestyle and lifestyle changes based on the LIBRA score Open
An individual's mean LIBRA score, but not their change in LIBRA score over time, was longitudinally associated with cognitive functioning. In the general population, the investigated version of the LIBRA score is possibly not suitable to c…
View article: Mental health outcomes and loneliness in older transgender individuals receiving long-term gender-affirming hormone therapy compared with older cisgender individuals
Mental health outcomes and loneliness in older transgender individuals receiving long-term gender-affirming hormone therapy compared with older cisgender individuals Open
Mental health outcomes and loneliness are compromised in older transgender individuals compared to cisgender individuals, particularly in transgender women. The socio-economic, psychological and somatic risk factors identified warrant furt…
View article: Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts
Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts Open
The combination of population-based and clinical cohorts, the coordinated assessment of plasma markers in previously collected samples and implementation and use of the Personal Health Train infrastructure for federated analysis are both f…
View article: Adopting a Complex Systems Approach to Functional Ageing: Bridging the Gap between Gerontological Theory and Empirical Research
Adopting a Complex Systems Approach to Functional Ageing: Bridging the Gap between Gerontological Theory and Empirical Research Open
Related to but distinct from biological and environmental systems, we define functional ageing as the interacting changes in physical and mental body functions, behavioural factors and social participation that occur as individuals age. We…
View article: Adopting a complex systems approach to functional ageing: bridging the gap between gerontological theory and empirical research
Adopting a complex systems approach to functional ageing: bridging the gap between gerontological theory and empirical research Open
Functional ageing, related to but distinct from biological and environmental systems, is defined as the changes in physical, psychological, cognitive, and social functioning, as well as behavioural factors of individuals as they age. In th…
View article: Associations of personality trait level and change with mortality risk in 11 longitudinal studies.
Associations of personality trait level and change with mortality risk in 11 longitudinal studies. Open
People who are higher in conscientiousness, extraversion, and agreeableness and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be …
View article: Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects Open
View article: Affective Aspects of Religiousness and 6-Year Course of Depressive Symptoms in Aged Dutch Citizens
Affective Aspects of Religiousness and 6-Year Course of Depressive Symptoms in Aged Dutch Citizens Open
In prospective studies on religiousness and depressive symptoms, it remains unclear whether religiousness is a predictor or parallels the fluctuating course of depressive symptoms. The current study focuses on several affective aspects of …
View article: Biomarkers of endothelial dysfunction and cognition: A two‐step IPD meta‐analysis
Biomarkers of endothelial dysfunction and cognition: A two‐step IPD meta‐analysis Open
INTRODUCTION This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline. METHODS Data from 9414 individuals from eight Dutch cohorts were included (Ø age‐range: 57–93 years). …
View article: The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam
The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam Open
View article: Trends in de toereikendheid van de langdurige zorg onder ouderen in de periode van de hervorming van de langdurige zorg
Trends in de toereikendheid van de langdurige zorg onder ouderen in de periode van de hervorming van de langdurige zorg Open
Due to population ageing and rising healthcare costs, Dutch long-term care was reformed in 2015. Important measures were stricter admission requirements for nursing homes and decentralization of home care to municipalities. The consequence…
View article: Associations of Personality Trait Level and Change with Mortality Risk in 11 Longitudinal Studies
Associations of Personality Trait Level and Change with Mortality Risk in 11 Longitudinal Studies Open
People who are higher in conscientiousness, extraversion, and agreeableness, and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be…
View article: Self-perceived functioning, goals and action plans: an evaluation of an ICF-based E-health application in an intervention for people with a combination of mental and physical health conditions
Self-perceived functioning, goals and action plans: an evaluation of an ICF-based E-health application in an intervention for people with a combination of mental and physical health conditions Open
Our study demonstrates that all categories of the ICF can be used to record self-perceived functioning, goals and action plans and monitor changes over time.
View article: Transitions between care networks: a prospective study among older adults in the Netherlands
Transitions between care networks: a prospective study among older adults in the Netherlands Open
View article: Adopting a Complex Systems Approach to Functional Ageing: Bridging the Gap between Gerontological Theory and Empirical Research
Adopting a Complex Systems Approach to Functional Ageing: Bridging the Gap between Gerontological Theory and Empirical Research Open
Related to but distinct from biological and environmental systems, we define functional ageing as the interacting changes in physical and mental body functions, behavioural factors and social participation that occur as individuals age. We…