Daniel Jaque
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View article: Accurate and Fast Thermal Sensing via Phase-Responsive Nanothermometers and Neural Networks
Accurate and Fast Thermal Sensing via Phase-Responsive Nanothermometers and Neural Networks Open
Accurate, rapid, and remote temperature sensing at the nanoscale is essential for applications ranging from monitoring cellular thermodynamics to thermal management of microelectronic devices. Luminescent nanothermometers are promising can…
View article: Near‐Infrared Lifetime Nanothermometry Detects Microwave‐Induced Brain Heating
Near‐Infrared Lifetime Nanothermometry Detects Microwave‐Induced Brain Heating Open
In modern environments, the brain is continuously exposed to numerous external stimuli, including the microwave radiation used in telecommunication technologies. It has been suggested that the absorption of this radiation by brain tissue c…
View article: Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging
Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging Open
Fluorescent probes operating within the near-infrared second window (NIR-II, 1000-1700 nm), characterized by high tissue transparency and minimal tissue-induced photon scattering/absorption, have been widely applied for early-stage disease…
View article: PEGylating Ag<sub>2</sub>S Semiconductor Nanocrystals for Pharmacokinetics Tracking: Insights from NIR Luminescence Imaging
PEGylating Ag<sub>2</sub>S Semiconductor Nanocrystals for Pharmacokinetics Tracking: Insights from NIR Luminescence Imaging Open
Nanotechnology has revolutionized biomedical applications through the development of nanomaterials with tailored properties, particularly in disease diagnosis and treatment. However, challenges remain regarding the pharmacokinetics of nano…
View article: Infrared emitting lanthanide doped nanoparticles provide sensing capabilities to coronary implants
Infrared emitting lanthanide doped nanoparticles provide sensing capabilities to coronary implants Open
Intracoronary stents have revolutionized the treatment of coronary obstructions, allowing for minimally invasive procedures and significantly enhancing both therapeutic efficacy and patient quality of life. Despite their clinical success, …
View article: Infrared emitting lanthanide doped nanoparticles provide sensing capabilities to coronary implants
Infrared emitting lanthanide doped nanoparticles provide sensing capabilities to coronary implants Open
Intracoronary stents have revolutionized the treatment of coronary obstructions, allowing for minimally invasive procedures and significantly enhancing both therapeutic efficacy and patient quality of life. Despite their clinical success, …
View article: Luminescence Fingerprint of Intracellular NIR-II Gold Nanocluster Transformation: Implications for Sensing and Imaging
Luminescence Fingerprint of Intracellular NIR-II Gold Nanocluster Transformation: Implications for Sensing and Imaging Open
Gold nanoclusters emitting in the second biological window (NIR-II-AuNCs) have gained significant interest for their potential in deep-tissue bioimaging and biosensing applications due to the partial transparency and reduced autofluorescen…
View article: A Chromatic Nanoswitcher for Thermal Monitoring of Cell Metabolism
A Chromatic Nanoswitcher for Thermal Monitoring of Cell Metabolism Open
Accurate sensing of intracellular temperature is crucial for understanding and monitoring cell metabolism, serving as an initial step toward diagnosing conditions such as mitochondria‐related diseases. However, thermal monitoring of cell m…
View article: Magnetic hyperthermia-triggered multi-functional thermo-responsive lipid nanoparticles for enhanced paclitaxel release and cytotoxicity
Magnetic hyperthermia-triggered multi-functional thermo-responsive lipid nanoparticles for enhanced paclitaxel release and cytotoxicity Open
Multi-functional TLNs were fabricated for magnetically triggered hyperthermic release to enhance cytotoxicity against breast tumour cells.
View article: Two photon-responsive gold nanocapsules enable targeted photothermal hyperthermia of chemoresistant melanoma: injection-route-dependent efficacy and renal evidence of fragment clearance
Two photon-responsive gold nanocapsules enable targeted photothermal hyperthermia of chemoresistant melanoma: injection-route-dependent efficacy and renal evidence of fragment clearance Open
Gold–polymer nanocapsules enable image-guided, intratumoural photothermal therapy of melanoma. Intrinsic properties allow for two-photon luminescence imaging prior to local heating.
View article: Multifunctional azo-BODIPY-functionalised upconversion nanoparticles as sensors of hypoxia in biological environments
Multifunctional azo-BODIPY-functionalised upconversion nanoparticles as sensors of hypoxia in biological environments Open
A near-infrared excitable hypoxia-sensitive sensor was designed with upconverting nanoparticles and an azo-dye, absorbing their visible emissions. In hypoxic environments, the azo bond is reduced, recovering the nanoparticles’ upconversion…
View article: Unlocking Single‐Particle Multiparametric Sensing: Decoupling Temperature and Viscosity Readouts through Upconverting Polarized Spectroscopy
Unlocking Single‐Particle Multiparametric Sensing: Decoupling Temperature and Viscosity Readouts through Upconverting Polarized Spectroscopy Open
Upconverting particles (UCPs), renowned for their capability to convert infrared to visible light, serve as invaluable imaging probes. Furthermore, their responsiveness to diverse external stimuli holds promise for leveraging UCPs as remot…
View article: Synergistic Enhancement of Photodynamic Cancer Therapy with Mesenchymal Stem Cells and Theranostic Nanoparticles
Synergistic Enhancement of Photodynamic Cancer Therapy with Mesenchymal Stem Cells and Theranostic Nanoparticles Open
Nanoparticles engineered to combat cancer and other life-threatening diseases may significantly improve patient outcomes. However, inefficient nanoparticle delivery to tumors limits their use and necessitates the development of complex del…
View article: New Insights in Luminescence and Quenching Mechanisms of Ag<sub>2</sub>S Nanocrystals through Temperature-Dependent Spectroscopy
New Insights in Luminescence and Quenching Mechanisms of Ag<sub>2</sub>S Nanocrystals through Temperature-Dependent Spectroscopy Open
Bright near-infrared-emitting Ag2S nanocrystals (NCs) are used for in vivo temperature sensing relying on a reversible variation in intensity and photoluminescence lifetime within the physiological temperature range. Here, to gain insights…
View article: Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile
Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile Open
This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at…
View article: Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile
Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile Open
This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at…
View article: Brownian Motion Governs the Plasmonic Enhancement of Colloidal Upconverting Nanoparticles
Brownian Motion Governs the Plasmonic Enhancement of Colloidal Upconverting Nanoparticles Open
Upconverting nanoparticles are essential in modern photonics due to their ability to convert infrared light to visible light. Despite their significance, they exhibit limited brightness, a key drawback that can be addressed by combining th…
View article: Finite element modeling of plasmonic resonances in photothermal gold nanoparticles embedded in cells
Finite element modeling of plasmonic resonances in photothermal gold nanoparticles embedded in cells Open
The plasmonic response of Au nanospheres (NSs) in MCF-7 cells is investigated comparing experimental data with 3D simulations. Our findings highlight the impact of NS assembly, the surrounding medium, and interparticle gap on photothermal …
View article: Early in vivo detection of denervation‐induced atrophy by luminescence transient nanothermometry
Early in vivo detection of denervation‐induced atrophy by luminescence transient nanothermometry Open
Denervation induces skeletal muscle atrophy due to the loss of control and feedback with the nervous system. Unfortunately, muscle atrophy only becomes evident days after the denervation event when it could be irreversible. Alternative dia…
View article: Neural Networks Push the Limits of Luminescence Lifetime Nanosensing
Neural Networks Push the Limits of Luminescence Lifetime Nanosensing Open
Luminescence lifetime‐based sensing is ideally suited to monitor biological systems due to its minimal invasiveness and remote working principle. Yet, its applicability is limited in conditions of low signal‐to‐noise ratio (SNR) induced by…
View article: Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation
Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation Open
Denervation-induced muscle atrophy is a frequent cause of skeletal muscle diseases. However, the role of the most important muscle growth factor, insulin-like growth factor (IGF-1), in this process is poorly understood. IGF-1 activity is c…
View article: Ag<sub>2</sub>S Biocompatible Ensembles as Dual OCT Contrast Agents and NIR Ocular Imaging Probes
Ag<sub>2</sub>S Biocompatible Ensembles as Dual OCT Contrast Agents and NIR Ocular Imaging Probes Open
Ag 2 S nanoparticles (NPs) emerge as a unique system that simultaneously features in vivo near‐infrared (NIR) imaging, remote heating, and low toxicity thermal sensing. In this work, their capabilities are extended into the fields of optic…
View article: A Generalized Approach to Photon Avalanche Upconversion in Luminescent Nanocrystals
A Generalized Approach to Photon Avalanche Upconversion in Luminescent Nanocrystals Open
Photon avalanching nanoparticles (ANPs) exhibit extremely nonlinear upconverted emission valuable for subdiffraction imaging, nanoscale sensing, and optical computing. Avalanching has been demonstrated with Tm3+-, Pr3+-, or Nd3+-doped nano…
View article: Exploring the Origin of the Thermal Sensitivity of Near-Infrared-II Emitting Rare Earth Nanoparticles
Exploring the Origin of the Thermal Sensitivity of Near-Infrared-II Emitting Rare Earth Nanoparticles Open
Rare-earth doped nanoparticles (RENPs) are attracting increasing interest in materials science due to their optical, magnetic, and chemical properties. RENPs can emit and absorb radiation in the second biological window (NIR-II, 1000-1400 …
View article: 3D Optical Coherence Thermometry Using Polymeric Nanogels
3D Optical Coherence Thermometry Using Polymeric Nanogels Open
In nanothermometry, the use of nanoparticles as thermal probes enables remote and minimally invasive sensing. In the biomedical context, nanothermometry has emerged as a powerful tool where traditional approaches, like infrared thermal sen…
View article: A generalized approach to photon avalanche upconversion in luminescent nanocrystals
A generalized approach to photon avalanche upconversion in luminescent nanocrystals Open
Photon avalanching nanoparticles (ANPs) exhibit extremely nonlinear upconverted emission valuable for sub-diffraction imaging, nanoscale sensing, and optical computing. Avalanching has been demonstrated with Tm3+, Nd3+ or Pr3+-doped nanocr…
View article: Bias in Intracellular Luminescence Thermometry: The Case of the Green Fluorescent Protein
Bias in Intracellular Luminescence Thermometry: The Case of the Green Fluorescent Protein Open
Measurement of intracellular temperature in a fast, accurate, reliable, and remote manner is crucial for the understanding of cellular processes. Nanothermometers based on the green fluorescence protein (GFP) are of special interest becaus…
View article: Improving optical trapping of a single upconverting nanoparticle by plasmonic structure
Improving optical trapping of a single upconverting nanoparticle by plasmonic structure Open
Upconverting nanoparticles have been used as optical probes in a great variety of scenarios ranging from cells to animal model. A single upconverting nanoparticles can be remotely manipulated by laser in a contactless way. When assessing a…