Daniel Jeffares
YOU?
Author Swipe
View article: A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis
A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis Open
Parasites of the Leishmania donovani complex are responsible for visceral leishmaniasis, a vector-borne disease transmitted through the bite of female phlebotomine sand flies. As well as the human hosts, these parasites infect many mammals…
View article: A novel<i>Leishmania infantum</i>reference strain for gene editing and the study of visceral leishmaniasis
A novel<i>Leishmania infantum</i>reference strain for gene editing and the study of visceral leishmaniasis Open
Parasites of the Leishmania donovani complex are responsible for visceral leishmaniasis, a vector-borne disease transmitted through the bite of female phlebotomine sand flies. As well as the human hosts, these parasites infect many mammals…
View article: Molecular Insights into Cell-Mediated Immunity in Atypical Non-Ulcerated Cutaneous Leishmaniasis
Molecular Insights into Cell-Mediated Immunity in Atypical Non-Ulcerated Cutaneous Leishmaniasis Open
Leishmania (Leishmania) infantum chagasi infections range from asymptomatic (AS) to severe visceral leishmaniasis (VL). One of the manifestations is an atypical non-ulcerated cutaneous leishmaniasis (NUCL), which occurs in some locations o…
View article: The global dispersal of visceral leishmaniasis occurred within human history
The global dispersal of visceral leishmaniasis occurred within human history Open
The Leishmania donovani species complex (LdSC) causes visceral leishmaniasis (VL), is present in Africa, Europe, the Middle East, Asia and the Americas, and causes 20-40,000 fatalities per year. Previous analyses concluded that dispersal o…
View article: Estimating the rate of sexual reproduction and the inbreeding rate in<i>Leishmania</i>
Estimating the rate of sexual reproduction and the inbreeding rate in<i>Leishmania</i> Open
Many eukaryotic species undergo sexual reproduction facultatively, either in response to stress or in particular environments. For the remainder of their life cycle they reproduce by mitosis. This facultative sex may be rare, which alters …
View article: Pseudomolecule-scale genome assemblies of <i>Drepanocaryum sewerzowii</i> and <i>Marmoritis complanata</i>
Pseudomolecule-scale genome assemblies of <i>Drepanocaryum sewerzowii</i> and <i>Marmoritis complanata</i> Open
The Nepetoideae, a subfamily of Lamiaceae (mint family), is rich in aromatic plants, many of which are sought after for their use as flavors and fragrances or for their medicinal properties. Here, we present genome assemblies for two speci…
View article: Detecting complex infections in Trypanosomatids using whole genome sequencing
Detecting complex infections in Trypanosomatids using whole genome sequencing Open
Background Trypanosomatid parasites are a group of protozoans that cause devastating diseases that disproportionately affect developing countries. These protozoans have developed several mechanisms for adaptation to survive in the mammalia…
View article: Genome Report: Pseudomolecule-scale genome assemblies of<i>Drepanocaryum sewerzowii</i>and<i>Marmoritis complanata</i>
Genome Report: Pseudomolecule-scale genome assemblies of<i>Drepanocaryum sewerzowii</i>and<i>Marmoritis complanata</i> Open
The Nepetoideae, a subfamily of Lamiaceae (mint family), is rich in aromatic plants, many of which are sought after for their use as flavours and fragrances or for their medicinal properties. Here we present genome assemblies for two speci…
View article: Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites
Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites Open
Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum and L. donovani parasites rapidly enter into quiescence after an estimated 2–3 …
View article: Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites Open
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanced gene cop…
View article: PA-682 Overcoming diverse challenges associated with innovative multicountry collaborative initiatives: the Kenyan experience of the Prev_PKDL project
PA-682 Overcoming diverse challenges associated with innovative multicountry collaborative initiatives: the Kenyan experience of the Prev_PKDL project Open
Background The EDCTP-funded PREV_PKDL project was designed to: i) advance the clinical development of a vaccine for prevention of visceral leishmaniasis (VL)/post kala azar dermal leishmaniasis (PKDL) and ii) to gain a greater understandin…
View article: Long-term hematopoietic stem cells trigger quiescence in<i>Leishmania</i>parasites
Long-term hematopoietic stem cells trigger quiescence in<i>Leishmania</i>parasites Open
SUMMARY Quiescence and posttreatment relapse constitute an important therapeutic constraint across the microbiological spectrum. This study unveils that Leishmania infantum and L. donovani parasites rapidly enter quiescence after an estima…
View article: Aneuploidies are an ancestral feature of trypanosomatids, and an ancient chromosome duplication is maintained in extant species
Aneuploidies are an ancestral feature of trypanosomatids, and an ancient chromosome duplication is maintained in extant species Open
Background Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanc…
View article: Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies
Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies Open
In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. Yet the parasite factors t…
View article: Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis
Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis Open
Multiple factors contribute to the risk of mortality from visceral leishmaniasis (VL), including, patient genotype, comorbidities, and nutrition. Many of these factors are influenced by socioeconomic biases.
View article: Resolving Complexities in Taxonomic Lineages of the Organellar and Nuclear Genomes of <i>Galdieria</i> through Comparative Phylogenomic Analysis
Resolving Complexities in Taxonomic Lineages of the Organellar and Nuclear Genomes of <i>Galdieria</i> through Comparative Phylogenomic Analysis Open
Exploration of life in extreme environments allows the discovery of intriguing organisms with extraordinary biotechnological potential. An example of extreme environments is represented by hot springs, where harsh conditions (pH < 1; Tempe…
View article: Comparisons between Complete Genomes of the Eukaryotic Extremophile <i>Galdieria sulphuraria</i> Reveals Complex Nuclear Chromosomal Structures
Comparisons between Complete Genomes of the Eukaryotic Extremophile <i>Galdieria sulphuraria</i> Reveals Complex Nuclear Chromosomal Structures Open
Extremophiles, while typically bacteria and archaea, are also found in the eukaryotic domain of life. The eukaryote Galdieria sulphuraria is a thermoacidophilic red alga belonging to the class Cyanidiophyceae , an especially unique class a…
View article: Selective whole-genome amplification reveals population genetics of<i>Leishmania braziliensis</i>directly from patient skin biopsies
Selective whole-genome amplification reveals population genetics of<i>Leishmania braziliensis</i>directly from patient skin biopsies Open
In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. Yet the parasite factors t…
View article: Strong effects of parasite genotype on drug susceptibility in the Indian subcontinent
Strong effects of parasite genotype on drug susceptibility in the Indian subcontinent Open
Intracellular parasites of the Leishmania donovani species complex cause visceral leishmaniasis (VL). For parasitic diseases, VL has a mortality rate second only to malaria, and is associated with poverty-stricken areas of the world: prima…
View article: Parasite genotype is a major predictor of mortality from visceral leishmaniasis
Parasite genotype is a major predictor of mortality from visceral leishmaniasis Open
/Summary Background Visceral leishmaniasis (VL) is a potentially fatal disease mainly caused by Leishmania infantum in South America and L. donovani in Asia and Africa. Disease outcomes have been associated with patient genotype, nutrition…
View article: Phenotypic diversity of a clonal Ralstonia solanacearum pathogen lineage is explained by accessory genome variation
Phenotypic diversity of a clonal Ralstonia solanacearum pathogen lineage is explained by accessory genome variation Open
Ralstonia solanacearumis aplant pathogenic gram-negative bacterium capable of infecting several economically important crops such as potato and tomato. It can also persist in environmental reservoirs including soils, rivers and in asymptom…
View article: Supplementary Tables
Supplementary Tables Open
Supplementary Tables
View article: Supplementary Tables 2
Supplementary Tables 2 Open
Supplementary tables V2.
View article: Supplementary Tables
Supplementary Tables Open
Supplementary Tables
View article: Identification of individual root-knot nematodes using low coverage long-read sequencing
Identification of individual root-knot nematodes using low coverage long-read sequencing Open
Root-knot nematodes (RKN; genus Meloidogyne ) are polyphagous plant pathogens of great economic importance to agriculturalists globally. These species are small, diverse, and can be challenging for accurate taxonomic identification. Many o…
View article: Candidates for Balancing Selection in<i>Leishmania donovani</i>Complex Parasites
Candidates for Balancing Selection in<i>Leishmania donovani</i>Complex Parasites Open
The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection in this species complex. We used 384 publicly available L.…