Daniel K. Langlois
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View article: Serum gastrointestinal biomarkers are transiently affected by elective orthopedic surgery and acute enteropathy in dogs
Serum gastrointestinal biomarkers are transiently affected by elective orthopedic surgery and acute enteropathy in dogs Open
Objective To investigate changes in gastrointestinal biomarkers over time in dogs undergoing elective orthopedic surgery and in dogs with acute nonspecific diarrhea (AD). Methods Prospective cohort study of 20 dogs undergoing surgical repa…
View article: Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum Open
Hypoadrenocorticism is a serious condition in dogs that results from autoimmune adrenalitis and depletion of mineralocorticoids and glucocorticoids. Affected dogs respond well to glucocorticoid supplementation and treatment with the synthe…
View article: Cystoscopy-assisted urolith retrieval via a perineal urethrostomy stoma in male cats
Cystoscopy-assisted urolith retrieval via a perineal urethrostomy stoma in male cats Open
Objectives We sought to characterize cystoscopy-assisted urolith retrieval via a perineal urethrostomy stoma (CUPU) initially in a cadaveric model and then in clinical cases. We hypothesized that a CUPU would provide a reasonable alternati…
View article: Prednisolone pharmacokinetics in dogs with protein‐losing enteropathy
Prednisolone pharmacokinetics in dogs with protein‐losing enteropathy Open
Background It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein‐losing enteropathy (PLE). Objective To compare pharmacokinetics (PK) of orally administered prednisolon…
View article: Association of time to start of enteral nutrition and outcome in cats with hepatic lipidosis
Association of time to start of enteral nutrition and outcome in cats with hepatic lipidosis Open
Background Enteral nutrition (EN) is essential for management of hepatic lipidosis (HL) in cats. Objectives To determine if time to start of EN and other clinicopathologic variables are associated with outcome in cats with HL. Animals Fort…
View article: Case report: Androgen-secreting adrenocortical tumors in eight cats
Case report: Androgen-secreting adrenocortical tumors in eight cats Open
Urine marking, aggression, and other behavioral concerns are common reasons for cat owners to seek veterinary care. Empiric treatment for lower urinary tract disease or primary behavior disorders are commonly pursued, especially in those c…
View article: Urine electrolytes do not predict desoxycorticosterone pivalate efficacy in dogs with hypoadrenocorticism
Urine electrolytes do not predict desoxycorticosterone pivalate efficacy in dogs with hypoadrenocorticism Open
OBJECTIVE To determine if urine electrolyte assessments can be used to monitor the adequacy of mineralocorticoid therapy in dogs with hypoadrenocorticism (HA). ANIMALS 29 dogs with naturally occurring glucocorticoid- and mineralocorticoid-…
View article: Clinical utility of an immunoglobulin A‐based serological panel for the diagnosis of chronic enteropathy in dogs
Clinical utility of an immunoglobulin A‐based serological panel for the diagnosis of chronic enteropathy in dogs Open
Background A panel of IgA‐based serologic assays might aid in the diagnosis of chronic enteropathy (CE) in dogs, a syndrome encompassing conditions such as food‐responsive enteropathy, immunosuppressant‐responsive enteropathy, and inflamma…
View article: Cardiovascular abnormalities in dogs with acute pancreatitis
Cardiovascular abnormalities in dogs with acute pancreatitis Open
Background The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown. Animals Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP. Methods Two‐phase study. Pha…
View article: Relationship between serum magnesium, calcium, and parathyroid concentrations in dogs with abnormally low serum 25‐hydroxyvitamin D concentration and chronic or protein‐losing enteropathy
Relationship between serum magnesium, calcium, and parathyroid concentrations in dogs with abnormally low serum 25‐hydroxyvitamin D concentration and chronic or protein‐losing enteropathy Open
Background The relationship between the development of SHPT and ionized magnesium (iMg) concentrations in blood of dogs with chronic gastrointestinal (GI) disease and abnormally low 25(OH)D is undefined. Objectives Evaluate relationships b…
View article: Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis
Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis Open
Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant …
View article: Investigation of the urine cortisol to creatinine ratio for the diagnosis of hypoadrenocorticism in dogs
Investigation of the urine cortisol to creatinine ratio for the diagnosis of hypoadrenocorticism in dogs Open
OBJECTIVE To evaluate the urine cortisol-to-creatinine ratio (UCCR) for the diagnosis of hypoadrenocorticism (HA) in dogs and to determine whether the method of urine cortisol measurement affects results. ANIMALS 41 dogs with naturally occ…
View article: Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®)
Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®) Open
View article: Letter regarding “Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs”
Letter regarding “Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs” Open
Dear Editors, We read with interest the paper by Estruch et al "Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs,"1 the results section of the abstract of which would sugge…
View article: Retrospective study of aldosterone and progesterone secreting adrenal tumors in 10 cats
Retrospective study of aldosterone and progesterone secreting adrenal tumors in 10 cats Open
Background Primary hyperaldosteronism caused by adrenal neoplasia has been well described in cats. Multiple corticosteroid abnormalities occur in a subset of affected cats, but characterizations of this syndrome are limited to several case…
View article: Multiple corticosteroid abnormalities in cats with hyperaldosteronism
Multiple corticosteroid abnormalities in cats with hyperaldosteronism Open
Background The frequency with which multiple corticosteroid abnormalities occur in cats with aldosterone secreting adrenocortical tumors is unknown. Objectives To evaluate adrenal‐derived corticosteroids in cats in which blood samples were…
View article: Low‐dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial
Low‐dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial Open
Background Desoxycorticosterone pivalate (DOCP) is a commonly used mineralocorticoid replacement for dogs with primary hypoadrenocorticism (HA), but manufacturer‐recommended dosing protocols can be cost‐prohibitive. Recent reports also hav…
View article: Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo‐controlled clinical trial
Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo‐controlled clinical trial Open
Background Metronidazole is commonly administered to dogs with acute diarrhea, but there is limited evidence to support this practice. Objective To investigate the effects of metronidazole administration on dogs with acute nonspecific diar…
View article: Prevalence, distribution, and risk factors for canine blastomycosis in Michigan, USA
Prevalence, distribution, and risk factors for canine blastomycosis in Michigan, USA Open
Blastomycosis is a systemic fungal infection that most commonly affects dogs and humans. The disease is thought to be endemic in southern regions of Michigan, USA, but epidemiologic investigations have not been reported in detail for this …
View article: Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma
Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) is the most common primary liver tumor in dogs. Abnormalities in hepatic copper, iron, zinc, and selenium concentrations increase risk for HCC development in other species, but trace mineral concen…
View article: Ammonium tetrathiomolybdate treatment of copper‐associated hepatopathy in dogs
Ammonium tetrathiomolybdate treatment of copper‐associated hepatopathy in dogs Open
Background Copper‐associated hepatopathy (CAH) is a common cause of liver disease in dogs. Although d ‐penicillamine can be an effective treatment, some dogs fail treatment or develop adverse effects. Ammonium tetrathiomolybdate (TTM) has …
View article: Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone
Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone Open
Background Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroi…
View article: Hepatic copper concentrations in 546 dogs (1982–2015)
Hepatic copper concentrations in 546 dogs (1982–2015) Open
Background Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects in copper metabolism have been exacerbated by increased environmental copper exposure. However, no broad …
View article: ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome
ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome Open
View article: Pharmacokinetics and Relative Bioavailability of Orally Administered Innovator‐Formulated Itraconazole Capsules and Solution in Healthy Dogs
Pharmacokinetics and Relative Bioavailability of Orally Administered Innovator‐Formulated Itraconazole Capsules and Solution in Healthy Dogs Open
Background Itraconazole is commonly used for treatment of systemic and cutaneous mycoses in veterinary medicine. Two formulations, capsule and solution, are used interchangeably in dogs. However, marked differences in bioavailability have …
View article: Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs
Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs Open
Background Previous studies that included limited numbers of affected dogs have suggested basal cortisol concentrations ≤55 nmol/L (2 μg/dL) are sensitive, but nonspecific, for a diagnosis of hypoadrenocorticism. A detailed assessment of t…
View article: Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs
Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs Open
OBJECTIVE To evaluate pharmacokinetics of ammonium tetrathiomolybdate (TTM) after IV and oral administration to dogs and effects of TTM administration on trace mineral concentrations. ANIMALS 8 adult Beagles and Beagle crossbreds (4 sexual…