Daniel Kalman
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View article: Blood group A enhances SARS-CoV-2 infection
Blood group A enhances SARS-CoV-2 infection Open
Among the risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ABO(H) blood group antigens are among the most recognized predictors of infection. However, the mechanisms by which ABO(H) antigens influence suscepti…
View article: The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas
The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas Open
Infections caused by members of the mycobacterium tuberculosis complex [MTC] and nontuberculous mycobacteria [NTM] can induce widespread morbidity and mortality in people. Mycobacterial infections cause both a delayed immune response, whic…
View article: A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging
A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging Open
During aging, environmental stressors and mutations along with reduced DNA repair cause germ cell aneuploidy and genome instability, which limits fertility and embryo development. Benevolent commensal microbiota and dietary plants secrete …
View article: The host-directed therapeutic imatinib mesylate accelerates immune responses to<i>Mycobacterium marinum</i>infection and limits pathology associated with granulomas
The host-directed therapeutic imatinib mesylate accelerates immune responses to<i>Mycobacterium marinum</i>infection and limits pathology associated with granulomas Open
Mycobacterial infections, including those caused by members of the mycobacterium tuberculosis complex [MTC] and Nontuberculous mycobacteria [NTM], can induce widespread morbidity and mortality in people. Mycobacterial infections cause both…
View article: Blood Group A Enhances SARS-CoV-2 Infection
Blood Group A Enhances SARS-CoV-2 Infection Open
BACKGROUND: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) continues to infect millions of individuals worldwide. However, not all individuals are equally susceptible to infection. Many studies have demonstrated that the firs…
View article: The immunoregulatory landscape of human tuberculosis granulomas
The immunoregulatory landscape of human tuberculosis granulomas Open
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationshi…
View article: The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A Open
Key Points The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A …
View article: Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging
Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging Open
Significance Aging is associated with an increase in baseline inflammation, called inflammaging, that may contribute to frailty in geriatric populations. Inflammaging could result from a decrease in anti-inflammatory mediators, such as IL-…
View article: Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents
Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents Open
Our results suggest that prairie dogs and monkeys may be suitable rodent and non-rodent species to perform further efficacy testing of these TKIs against orthopoxvirus infections. The use of rodent models such as C57BL/6 mice and guinea pi…
View article: The Evasive Enemy: Insights into the Virulence and Epidemiology of the Emerging Attaching and Effacing Pathogen<i>Escherichia albertii</i>
The Evasive Enemy: Insights into the Virulence and Epidemiology of the Emerging Attaching and Effacing Pathogen<i>Escherichia albertii</i> Open
The diarrheic attaching and effacing (A/E) pathogen Escherichia albertii was first isolated from infants in Bangladesh in 1991, although the bacterium was initially classified as Hafnia alvei . Subsequent genetic and biochemical interrogat…
View article: Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease
Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease Open
The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD seve…
View article: In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of<i>Mycobacterium tuberculosis</i>
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of<i>Mycobacterium tuberculosis</i> Open
Significance Mycobacterium tuberculosis induces the expression of the indoleamine 2,3-dioxygenase (IDO) enzyme, which catabolizes tryptophan. Tryptophan metabolites potently suppress host immunity. The present study demonstrates that block…
View article: Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3
Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3 Open
Significance The host interferon system is a potent antiviral system, responsible for protecting vertebrate organisms against virus infection. In this paper we demonstrate that the N terminus of the vaccinia virus innate immune evasion pro…
View article: Layered defense: how mucus and tight junctions seal the intestinal barrier
Layered defense: how mucus and tight junctions seal the intestinal barrier Open
The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease pro…