Daniel Kiboi
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View article: Investigation of prevalence and phylogenetic classification of Microsporidia MB and insecticide target site insensitivity resistance mutations in Anopheles gambiae s.l. and Anopheles funestus mosquitoes from Busia, Kenya
Investigation of prevalence and phylogenetic classification of Microsporidia MB and insecticide target site insensitivity resistance mutations in Anopheles gambiae s.l. and Anopheles funestus mosquitoes from Busia, Kenya Open
The present study highlights the occurrence of Microsporidia MB in multiple Anopheles vectors associated with malaria suggesting its broader potential as a vector control tool. The high prevalence of kdr mutations indicate a significant ch…
View article: Prevalence, Genetic Diversity of Microsporidia MB, and Correlation to Insecticide Resistance in Anopheles gambiae s.l. and Anopheles funestus Mosquitoes in Busia, Kenya
Prevalence, Genetic Diversity of Microsporidia MB, and Correlation to Insecticide Resistance in Anopheles gambiae s.l. and Anopheles funestus Mosquitoes in Busia, Kenya Open
Background: The discovery of Microsporidia MB, a malaria-impairing symbiont in Anopheles arabiensis, suggests its potential for malaria control. This study investigated its prevalence and diversity in An. gambiae s.l. and An. funestus in B…
View article: Enhancing Student Comprehension of Paternity Assignment in Molecular Primatology: A Pilot Study Using a Shiny Web Application in Kenya
Enhancing Student Comprehension of Paternity Assignment in Molecular Primatology: A Pilot Study Using a Shiny Web Application in Kenya Open
Kinship is a major determinant of affiliative and mating behavior in primates. In field studies, identifying kin typically relies in part on genetic analysis, especially for discriminating paternal relationships. Such analyses assume knowl…
View article: Isolation and characterization of <i>Plasmodium falciparum</i> blood-stage persisters by improved selection protocols using dihydroartemisinin alone
Isolation and characterization of <i>Plasmodium falciparum</i> blood-stage persisters by improved selection protocols using dihydroartemisinin alone Open
Artemisinin-based combination therapies (ACTs) are vital for malaria treatment, but these are threatened by blood-stage persisters—dormant forms of Plasmodium parasites that can survive drug exposure and cause recrudescent infections. Here…
View article: Salvia officinalis-mediated synthesis of silver nanoparticles: Characterization and sub-acute toxicity profile in Wistar rats
Salvia officinalis-mediated synthesis of silver nanoparticles: Characterization and sub-acute toxicity profile in Wistar rats Open
Nanotechnology has transformed many scientific domains by providing novel approaches in environmental applications, material science, and medicine. Among the different nanomaterials being explored, silver nanoparticles (AgNPs) have drawn a…
View article: Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya
Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya Open
The Plasmodium falciparum Circumsporozoite Protein (PfCSP) has been used in developing the RTS,S, and R21 malaria vaccines. However, genetic polymorphisms within Pfcsp compromise the effectiveness of the vaccine. Thus, it is essential to c…
View article: Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA
Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA Open
Background Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and L…
View article: Prevalence of subclinical mastitis, associated risk factors and antimicrobial susceptibility pattern of bacteria isolated from milk of dairy cattle in Kajiado Central sub‐county, Kenya
Prevalence of subclinical mastitis, associated risk factors and antimicrobial susceptibility pattern of bacteria isolated from milk of dairy cattle in Kajiado Central sub‐county, Kenya Open
Background Literature is scarce on the occurrence of bovine mastitis and antimicrobial resistance among dairy animals kept by pastoralists in the Kenya. Objectives A cross‐sectional study was carried out to investigate the prevalence and r…
View article: Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA
Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA Open
Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ) are the essential long-acting partner drugs in the artemisinin-based combination therapies (ACTs) treatment regimens globally. The recent report on the emergence of arte…
View article: Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA
Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA Open
Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and…
View article: Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA
Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA Open
Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ) are the essential long-acting partner drugs in the artemisinin-based combination therapies (ACTs) treatment regimens globally. The recent report on the emergence of art…
View article: Prevalence and Potential Risk Factors for the Acquisition of Antibiotic‐Resistant <i>Staphylococcus</i> spp. Bacteria Among Pastoralist Farmers in Kajiado Central Subcounty, Kenya
Prevalence and Potential Risk Factors for the Acquisition of Antibiotic‐Resistant <i>Staphylococcus</i> spp. Bacteria Among Pastoralist Farmers in Kajiado Central Subcounty, Kenya Open
Antimicrobial resistance (AMR) is a growing health problem globally. To address this challenge, there is a need to generate baseline data on the prevalence and AMR profile of the main disease‐causing bacteria. Here, we interrogated the pre…
View article: Prevalence, risk factors and antibiogram of bacteria isolated from skin of human having close contact with dairy cows in small-holder farms in Gatundu Sub-County, Kenya
Prevalence, risk factors and antibiogram of bacteria isolated from skin of human having close contact with dairy cows in small-holder farms in Gatundu Sub-County, Kenya Open
Background: Antimicrobial resistance is a global health crisis which needs surveillance especially in people having close contact with animals.Methods: A total of 120 skin swabs from around the neck region were obtained from human responde…
View article: Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA
Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA Open
Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and…
View article: Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA
Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA Open
Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ) are the essential long-acting partner drugs in the artemisinin-based combination therapies (ACTs) treatment regimens globally. Understanding the resistance mechanisms t…
View article: Artemisinin Binds and Inhibits the Activity of Plasmodium falciparum Ddi1, a Retroviral Aspartyl Protease
Artemisinin Binds and Inhibits the Activity of Plasmodium falciparum Ddi1, a Retroviral Aspartyl Protease Open
Reduced sensitivity of the human malaria parasite, Plasmodium falciparum, to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic ins…
View article: Artemisinin acts by inhibiting <i>Plasmodium falciparum</i> Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins
Artemisinin acts by inhibiting <i>Plasmodium falciparum</i> Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins Open
Reduced sensitivity of the human malaria parasite, Plasmodium falciparum, to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic ins…
View article: Occurrence of Beta-Lactamases Genes in Beta-Lactam Resistant Bacteria Isolated from Milk of Goats with Sub-Clinical Mastitis in Thika Sub-County, Kenya
Occurrence of Beta-Lactamases Genes in Beta-Lactam Resistant Bacteria Isolated from Milk of Goats with Sub-Clinical Mastitis in Thika Sub-County, Kenya Open
For decades, beta-lactam antibiotics have played a critical role in the control of mastitis in animals. However, the emergence of beta-lactam-resistant bacteria poses a challenge to both human and veterinary medicine. In this regard, bacte…
View article: Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure
Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure Open
Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could dramatically improve current surveillance methods by allowing for accurate e…
View article: β-lactam resistance in bacteria associated with subclinical mastitis in goats in Thika Subcounty, Kenya
β-lactam resistance in bacteria associated with subclinical mastitis in goats in Thika Subcounty, Kenya Open
Aim: This study determined the resistance pattern to β-lactam antibiotics of bacteria isolated from goats with subclinical mastitis in Thika subcounty, Kenya. We also administered a questionnaire to assess the risk factors associated with …
View article: Genetic alteration of ferredoxin NADP<sup>+</sup>-reductase or cysteine desulfurase in piperaquine-resistant <i>Plasmodium berghei</i> restores susceptibility to lumefantrine and abolishes the impact of probenecid, verapamil, and cyproheptadine
Genetic alteration of ferredoxin NADP<sup>+</sup>-reductase or cysteine desulfurase in piperaquine-resistant <i>Plasmodium berghei</i> restores susceptibility to lumefantrine and abolishes the impact of probenecid, verapamil, and cyproheptadine Open
Chemotherapy remains central in the control of malaria; however, resistance has consistently thwarted these efforts. Currently, lumefantrine (LM), and piperaquine (PQ) drugs, are essential components in the mainstay artemisinin-based thera…
View article: Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei
Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei Open
Retroviral protease inhibitors (RPIs) such as lopinavir (LP) and saquinavir (SQ) are active against Plasmodium parasites. However, the exact molecular target(s) for these RPIs in the Plasmodium parasites remains poorly understood. We hypot…
View article: Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters
Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters Open
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria. …
View article: Deciphering the targets of retroviral protease inhibitors in <i>Plasmodium berghei</i>
Deciphering the targets of retroviral protease inhibitors in <i>Plasmodium berghei</i> Open
Retroviral protease inhibitors (RPIs) such as lopinavir (LP) and saquinavir (SQ) are active against Plasmodium parasites. However, the exact molecular target(s) for these RPIs in the Plasmodium parasites remains poorly understood. We hypot…
View article: Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters
Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters Open
Background: The human malaria parasite Plasmodium falciparum has evolved complex drug evasion mechanisms to all available antimalarials. To date, the combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomp…
View article: Data Set 1
Data Set 1 Open
Parasite densities in the 4DT used for determination of 50% and 90% effective dose