Daniel KL Cheuk
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View article: Characteristics and prognosis of paediatric normal karyotype acute myeloid leukaemia: A <scp>NOPHO</scp>‐<scp>DBH AML</scp> study
Characteristics and prognosis of paediatric normal karyotype acute myeloid leukaemia: A <span>NOPHO</span>‐<span>DBH AML</span> study Open
Summary Normal karyotype acute myeloid leukaemia (NK‐AML) in children is a heterogeneous subgroup with scarce data on characteristics and prognosis. We investigated NK‐AML in a large paediatric AML cohort from four trials of the Nordic Soc…
View article: Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia
Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia Open
Summary Non‐transfusion‐dependent thalassaemia (NTDT) is associated with chronic health problems. A cross‐sectional study was conducted in Hong Kong Chinese patients to evaluate the presentation and complications of NTDT. One hundred and n…
View article: Central Nervous System Disease and Outcome in Pediatric Acute Myeloid Leukemia: Results from NOPHO-DBH AML2012 Trial
Central Nervous System Disease and Outcome in Pediatric Acute Myeloid Leukemia: Results from NOPHO-DBH AML2012 Trial Open
Background: Central nervous system disease (CNS3) in pediatric acute myeloid leukemia (pAML) is reported in 6% to 29% of cases. However, its impact on event-free survival (EFS) and overall survival (OS) remains uncertain. This study evalua…
View article: Presence of Leukemia-Related Basophils and Mast Cells with Atypical Immunophenotype during Induction Should Not be Interpreted As Measurable Residual Disease in Children with Acute Myeloid Leukemia with <i>RUNX1</i>::<i>RUNX1T1</i>
Presence of Leukemia-Related Basophils and Mast Cells with Atypical Immunophenotype during Induction Should Not be Interpreted As Measurable Residual Disease in Children with Acute Myeloid Leukemia with <i>RUNX1</i>::<i>RUNX1T1</i> Open
In most study protocols for children with acute myeloid leukemia (AML), treatment response is assessed with flow cytometry (FCM) after one and/or two courses of induction treatment, impacting risk stratification. In AML with RUNX1::RUNX1T1…
View article: Measurable Residual Disease Monitoring during Treatment for Pediatric Acute Myeloid Leukemia in First Relapse Predicts Outcome
Measurable Residual Disease Monitoring during Treatment for Pediatric Acute Myeloid Leukemia in First Relapse Predicts Outcome Open
Despite overall survival (OS) rates of approximately 80% in recent collaborative trials, relapse remains the predominant cause of death in childhood acute myeloid leukemia (AML). We present disease characteristics, prognostic factors, and …
View article: Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13) Open
Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is a recurrent translocation in AML in infants or very young children and was recently included in the World Health Organization (WHO) Classification of Hematolymphoid Tumors. AML with t(7…
View article: High infection rates and risk‐adapted prevention strategies in contemporary pediatric allogeneic hematopoietic stem cell transplantation
High infection rates and risk‐adapted prevention strategies in contemporary pediatric allogeneic hematopoietic stem cell transplantation Open
With recent changes in hematopoietic stem cell transplantation (HSCT) practices, such as the increasing use of alternative donors and ex vivo T‐cell depletion, how various risk factors interplay and affect the timeline of infections have n…
View article: Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 Protocol
Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 Protocol Open
Hyperleukocytosis (HL) in pediatric acute myeloid leukemia (AML) is associated with severe complications and inferior outcome. We report results on HL patients included in the NOPHO-DBH AML 2012 study. We recommended immediate start of ful…
View article: Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma
Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma Open
Introduction Medulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents. However, therapy-related complications, such as therapy-related…
View article: Outcome prediction of chronic myeloid leukaemia (CML) in children
Outcome prediction of chronic myeloid leukaemia (CML) in children Open
Purpose We evaluated the existing risk assessment tools for CML in children. Patients and Methods A total of 55 patients from 1.4 to 18.0 years with newly diagnosed CML between 1996 and 2019 were included. Forty-nine patients presented in …
View article: Remote Ischemic Conditioning in Pediatric Cancer Patients Receiving Anthracycline Chemotherapy
Remote Ischemic Conditioning in Pediatric Cancer Patients Receiving Anthracycline Chemotherapy Open
RIC did not exhibit cardioprotective effects in childhood cancer patients receiving anthracycline-based chemotherapy. (Remote Ischaemic Preconditioning in Childhood Cancer [RIPC]; NCT03166813).
View article: Lipoprotein-X hyperlipidaemia in Chinese paediatric patients with liver graft-versus-host disease post-haematopoietic stem cell transplantation: two case reports
Lipoprotein-X hyperlipidaemia in Chinese paediatric patients with liver graft-versus-host disease post-haematopoietic stem cell transplantation: two case reports Open
resolved by 2 years post-transplant
View article: Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia Open
Summary A significant proportion of events in paediatric acute myeloid leukaemia (AML) are caused by resistant disease (RD). We investigated clinical and biological characteristics in 66 patients with RD from 1013 children with AML registe…
View article: Survival outcomes of children with relapsed or refractory myeloid leukemia associated with Down syndrome
Survival outcomes of children with relapsed or refractory myeloid leukemia associated with Down syndrome Open
Children with Down syndrome (DS) are at a significantly higher risk of developing acute myeloid leukemia, also termed myeloid leukemia associated with DS (ML-DS). In contrast to the highly favorable prognosis of primary ML-DS, the limited …
View article: Neutropenia and anaemia secondary to copper deficiency in a child receiving long-term jejunal feeding: a case report
Neutropenia and anaemia secondary to copper deficiency in a child receiving long-term jejunal feeding: a case report Open
In January 2017, a girl was born full term to nonconsanguineous Chinese parents.Oesophageal atresia with a distal tracheo-oesophageal fistula was diagnosed soon after birth.Emergency surgical repair was attempted on day 1 of life but was c…
View article: Significance of anti-neutrophil antibody in chronic benign neutropenia in Chinese children
Significance of anti-neutrophil antibody in chronic benign neutropenia in Chinese children Open
Background: Chronic benign neutropenia (CBN) and autoimmune neutropenia (AIN) are notoriously difficult to differentiate in children owing to their indistinguishable clinical course and varying availability and accuracy in the methods of a…
View article: Successful haploidentical hematopoietic stem cell transplantation (HSCT) and durable engraftment by repeated donor lymphocyte infusions for a Chinese patient with transfusion‐dependent hemoglobin (Hb) Hammersmith and massive splenomegaly
Successful haploidentical hematopoietic stem cell transplantation (HSCT) and durable engraftment by repeated donor lymphocyte infusions for a Chinese patient with transfusion‐dependent hemoglobin (Hb) Hammersmith and massive splenomegaly Open
Background Hemoglobin (Hb) Hammersmith is a rare form of unstable β‐chain hemoglobinopathy causing hemolytic anemia. This rare event led to a more serious transfusion‐dependent phenotype in a patient. It was successfully cured by haploiden…
View article: Neutropenia and anemia secondary to copper deficiency in a child receiving long term jejunal feeding
Neutropenia and anemia secondary to copper deficiency in a child receiving long term jejunal feeding Open
Jejunal feeding is increasingly utilized in the pediatric population to reduce gastroesophageal reflux or aspiration pneumonia. We describe a pediatric patient who developed persistent neutropenia and anemia secondary to copper deficiency …
View article: Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study
Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study Open
Despite therapeutic advances, early death (ED) remains a major factor curtailing survival of acute promyelocytic leukemia (APL). Studies examining factors that cause early death (ED; within 30 days of admission) and the correlation of surv…
View article: Brain Microstructural Changes Associated With Neurocognitive Outcome in Intracranial Germ Cell Tumor Survivors
Brain Microstructural Changes Associated With Neurocognitive Outcome in Intracranial Germ Cell Tumor Survivors Open
Background Childhood intracranial germ cell tumor (GCT) survivors are prone to radiotherapy-related neurotoxicity, which can lead to neurocognitive dysfunctions. Diffusion kurtosis imaging (DKI) is a diffusion MRI technique that is sensiti…
View article: QOL-25. MICROSTRUCTURAL BRAIN CHANGES ASSOCIATED WITH NEUROCOGNITIVE AND FUNCTIONAL OUTCOMES OF INTRACRANIAL GERM CELL TUMUOR SURVIVORS – A DIFFUSIONAL KURTOSIS IMAGING STUDY
QOL-25. MICROSTRUCTURAL BRAIN CHANGES ASSOCIATED WITH NEUROCOGNITIVE AND FUNCTIONAL OUTCOMES OF INTRACRANIAL GERM CELL TUMUOR SURVIVORS – A DIFFUSIONAL KURTOSIS IMAGING STUDY Open
BACKGROUND Childhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead to neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstru…
View article: Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong
Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong Open
The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and …
View article: Pediatric Application of Dynamic Contrast-Enhanced MR Imaging (DCE-MR) in the Management of Extra-Cranial Tumor: Experience in Routine Clinical Practice
Pediatric Application of Dynamic Contrast-Enhanced MR Imaging (DCE-MR) in the Management of Extra-Cranial Tumor: Experience in Routine Clinical Practice Open
Background: Dynamic contrast-enhanced MR imaging (DCE-MR) is becoming a widely accepted complementary method for diagnosing breast cancer and other cancers in adults. It is useful to predict tumor response to anticancer therapy and monitor…
View article: Risk factors for drug allergies in Chinese children
Risk factors for drug allergies in Chinese children Open
While several previous studies suggested a higher prevalence of IgE-mediated drug allergies in younger adult females, older boys were more likely to have drug allergies for Chinese children.
View article: Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment
Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment Open
We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia d…
View article: Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group
Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group Open
Key Points t(16;21) translocations in AML comprise t(16;21)(p11;q22) (FUS-ERG) as well as t(16;21)(q24;q22) (RUNX1-CBFA2T3). Survival in pediatric AML with FUS-ERG is poor, whereas survival in RUNX1-CBFA2T3 is similar to other core-binding…