Daniel Klinger
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View article: Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy
Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy Open
Antimicrobial polymers (AMP) are promising therapeutics to target bacterial pathogens. Sulfonium‐based AMPs offer a good balance between high antimicrobial activity and low cytotoxicity. Currently, sulfonium groups are mostly incorporated …
View article: Multi‐Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications
Multi‐Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications Open
Nanogels for biomedical applications require polymeric building blocks that show high hydrophilicity and (thermo‐)responsive properties without immune response risks. Polysulfoxides offer these advantages but have not yet been translated t…
View article: Sulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition
Sulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition Open
Structure–property relations for antimicrobial sulfonium-based polymers reveal that same-center structures show superior activity and selectivity compared to different-center and ammonium-based analogues of similar clog P .
View article: Nanogels with tailored hydrophobicity and their behavior at air/water interfaces
Nanogels with tailored hydrophobicity and their behavior at air/water interfaces Open
We investigate the interfacial morphology of colloidal nanogels with increasing hydrophobicity. The transition from deformable to solid-like characteristics occurs suddenly above a threshold in hydrophobicity.
View article: Amphiphilic Nanogels as Versatile Stabilizers for Pickering Emulsions
Amphiphilic Nanogels as Versatile Stabilizers for Pickering Emulsions Open
Pickering emulsions (PEs) are stabilized by particles at the water/oil interface and exhibit superior long-term stability compared to emulsions with molecular surfactants. Among colloidal stabilizers, nano/microgels facilitate emulsificati…
View article: Optically monitoring the microenvironment of a hydrophobic cargo in amphiphilic nanogels: influence of network composition on loading and release
Optically monitoring the microenvironment of a hydrophobic cargo in amphiphilic nanogels: influence of network composition on loading and release Open
Spectroscopic studies revealed that in amphiphilic nanogels Nile red locates in the hydrophobic domains and the border to the hydrophilic matrix.
View article: Rational Design and Development of Polymeric Nanogels as Protein Carriers
Rational Design and Development of Polymeric Nanogels as Protein Carriers Open
Proteins have gained significant attention as potential therapeutic agents owing to their high specificity and reduced toxicity. Nevertheless, their clinical utility is hindered by inherent challenges associated with stability during stora…
View article: Synthesis of New Degradable AB-Type Polyesters with 1,2,3-TriazoleRings in the Backbone via “Click” Step-Growth Polymerization
Synthesis of New Degradable AB-Type Polyesters with 1,2,3-TriazoleRings in the Backbone via “Click” Step-Growth Polymerization Open
A series of new aliphatic AB-type polyesters (PEs) and co-polyesters (co-PEs) with 1,2,3-triazole rings in the backbone were successfully synthesized via Cu(I)-catalyzed click step-growth polymerization (SGP) following the efficient one po…
View article: Regioselective Seeded Polymerization in Block Copolymer Nanoparticles: Post‐Assembly Control of Colloidal Features
Regioselective Seeded Polymerization in Block Copolymer Nanoparticles: Post‐Assembly Control of Colloidal Features Open
Post‐assembly modifications are efficient tools to adjust colloidal features of block copolymer (BCP) particles. However, existing methods often address particle shape, morphology, and chemical functionality individually. For simultaneous …
View article: Solvent Annealing of Striped Ellipsoidal Block Copolymer Particles: Reversible Control over Lamellae Asymmetry, Aspect Ratio, and Particle Surface
Solvent Annealing of Striped Ellipsoidal Block Copolymer Particles: Reversible Control over Lamellae Asymmetry, Aspect Ratio, and Particle Surface Open
Solvent annealing is a versatile tool to adjust the shape and morphology of block copolymer (BCP) particles. During this process, polar solvents are often used for block-selective swelling. However, such water-miscible solvents can induce …
View article: Dual-reactive nanogels for orthogonal functionalization of hydrophilic shell and amphiphilic network
Dual-reactive nanogels for orthogonal functionalization of hydrophilic shell and amphiphilic network Open
Dual-reactive precursor nanogels allow independent adjustment of core and shell properties. This versatile synthetic platform is based on post-polymerization modification to give access to multi-functional nanogels.
View article: Amphiphilic micro‐ and nanogels: Combining properties from internal hydrogel networks, solid particles, and micellar aggregates
Amphiphilic micro‐ and nanogels: Combining properties from internal hydrogel networks, solid particles, and micellar aggregates Open
Polymeric micro‐ and nanogels are defined by their water‐swollen hydrophilic networks that can often impart outstanding biocompatibility and high‐colloidal stability. Unfortunately, this highly hydrophilic nature limits their potential in …
View article: Tunable biohybrid hydrogels from coacervation of hyaluronic acid and PEO‐based block copolymers
Tunable biohybrid hydrogels from coacervation of hyaluronic acid and PEO‐based block copolymers Open
Accurately tuning the macroscopic properties of biopolymer‐based hydrogels remains challenging due to the ill‐defined molecular architecture of the natural building blocks. Here, we report a biohybrid coacervate hydrogel, combining the bio…
View article: Thermo- and oxidation-sensitive poly(meth)acrylates based on alkyl sulfoxides: dual-responsive homopolymers from one functional group
Thermo- and oxidation-sensitive poly(meth)acrylates based on alkyl sulfoxides: dual-responsive homopolymers from one functional group Open
Alkyl sulfoxide side groups introduce thermo- and oxidation-sensitivity into poly(meth)acrylates, thus realizing new dual-responsive homopolymers based on one functional group.
View article: Reactive Precursor Particles as Synthetic Platform for the Generation of Functional Nanoparticles, Nanogels, and Microgels
Reactive Precursor Particles as Synthetic Platform for the Generation of Functional Nanoparticles, Nanogels, and Microgels Open
Precise control of the chemical functionality of polymer nanoparticles is a key requirement in tailoring their (dynamic) colloidal properties toward advanced applications. However, current synthetic techniques are still limited in the vers…
View article: <p>Amphiphilic nanogels: influence of surface hydrophobicity on protein corona, biocompatibility and cellular uptake</p>
Amphiphilic nanogels: influence of surface hydrophobicity on protein corona, biocompatibility and cellular uptake Open
Background and purpose: Nanogels (NGs) are promising drug delivery tools but are typically limited to hydrophilic drugs. Many potential new drugs are hydrophobic. Our study systematically investigates amphiphilic NGs with varying hydrophob…
View article: A Scalable and Versatile Synthesis of Oxime‐Based Hormone Dimers and Gels for Sustained Release
A Scalable and Versatile Synthesis of Oxime‐Based Hormone Dimers and Gels for Sustained Release Open
Well‐defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here thro…
View article: A robust platform for functional microgels via thiol–ene chemistry with reactive polyether-based nanoparticles
A robust platform for functional microgels via thiol–ene chemistry with reactive polyether-based nanoparticles Open
Network functionalization of reactive precursor nanoparticles enables the facile preparation of degradable microgels that are responsive to different triggers but equal in morphology.