Daniel Kummer
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Real-world incidence of bleeding events in patients with chronic lymphocytic leukemia treated with acalabrutinib +/- obinutuzumab and requiring direct oral anticoagulation Open
Background: A significant proportion of patients (pts) with Chronic Lymphocytic Leukemia (CLL) have cardiovascular comorbidities requiring treatment with direct oral anti-coagulants (DOAC). However, Bruton's tyrosine kinase inhibitors (BTK…
View article: Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface
Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface Open
This study suggests that maternal platelet-derived factors affect the transcriptional profile of trophoblasts, including upregulation of LAIR2, which may be involved in fine-tuning the coagulation of maternal blood leaking from eroded deci…
The Microchimerism Literature Atlas Open
The Microchimerism Literature Atlas (MCLA) is a comprehensive online dataset to facilitate the investigation of microchimerism (MC), condition where individuals harbor cells from another individual of the same species. The MCLA provides ac…
Placental structural adaptation to maternal physical activity and sedentary behavior: findings of the DALI lifestyle study Open
STUDY QUESTION Are maternal levels of moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) in obese pregnant women associated with placental structural adaptations for facilitating oxygen delivery to the fetus? SUMMARY ANS…
View article: Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice Open
Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs).…
View article: Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts Open
Background The human placenta, a tissue with a lifespan limited to the period of pregnancy, is exposed to varying shear rates by maternal blood perfusion depending on the stage of development. In this study, we aimed to investigate the eff…
Automated stereological image analysis approach of the human placenta: Surface areas and vascularization Open
Detecting and quantifying surface densities of placental villi and their vasculature adds important information on the development of the placenta under different exposures and pathological conditions. Today, a larger number of samples and…
An Unbiased Approach of Sampling TEM Sections in Neuroscience Open
Investigations of the ultrastructural features of neurons and their synapses are only possible with electron microscopy. Especially for comparative studies of the changes in densities and distributions of such features, an unbiased samplin…