Daniel L. Plotkin
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View article: Effects of 12-Week Dietary Nitrate Supplementation with Resistance Training on Skeletal Muscle and Vascular Outcomes and in Older Adults
Effects of 12-Week Dietary Nitrate Supplementation with Resistance Training on Skeletal Muscle and Vascular Outcomes and in Older Adults Open
Increasing dietary nitrate (NO3-) through beetroot juice (BRJ) supplementation elicits acute ergogenic benefits. However, it is unknown whether chronic NO3- supplementation can enhance resistance training (RT) adaptations in middle-aged an…
View article: Disuse and subsequent recovery resistance training affect skeletal muscle angiogenesis-related markers regardless of prior resistance training experience
Disuse and subsequent recovery resistance training affect skeletal muscle angiogenesis-related markers regardless of prior resistance training experience Open
As a follow-up to our original investigation by Michel JM et al. J Appl Physiol (1985) 138: 450–467, 2025, we sought to examine how limb immobilization and recovery resistance training affect molecular outcomes related to angiogenesis in y…
View article: Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults
Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults Open
We sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of un…
View article: Does longer-muscle length resistance training cause greater longitudinal growth in humans? A systematic review
Does longer-muscle length resistance training cause greater longitudinal growth in humans? A systematic review Open
View article: Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance-trained versus untrained adults
Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance-trained versus untrained adults Open
Formerly trained and untrained individuals demonstrate similar atrophic responses to disuse while untrained individuals exhibited a greater hypertrophic response to subsequent resistance training. The molecular responses accompanying these…
View article: Leg immobilization and subsequent recovery resistance training affect skeletal muscle angiogenesis related markers in young healthy adults regardless of prior resistance training experience
Leg immobilization and subsequent recovery resistance training affect skeletal muscle angiogenesis related markers in young healthy adults regardless of prior resistance training experience Open
We recently reported that resistance trained (T, n=10) and untrained (UT, n=11) young adults experience vastus lateralis (VL) muscle atrophy following two weeks of disuse, and 8 weeks of recovery resistance training (RT) promotes VL hypert…
View article: The effects of resistance training to near volitional failure on motor unit recruitment during neuromuscular fatigue
The effects of resistance training to near volitional failure on motor unit recruitment during neuromuscular fatigue Open
Background It is unclear whether chronically training close to volitional failure influences motor unit recruitment strategies during fatigue. Purpose We compared resistance training to near volitional failure vs . non-failure on individua…
View article: Skeletal muscle myosin heavy chain fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy
Skeletal muscle myosin heavy chain fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy Open
We examined how resistance exercise (RE), cycling exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation. The 1boutRE study involved younger men ( n = 8; 5 ± 2 years of RE experience) performing a lower body RE …
View article: International Consensus on the Definition of Functional Training
International Consensus on the Definition of Functional Training Open
View article: Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance trained versus untrained adults
Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance trained versus untrained adults Open
We sought to examine how resistance training (RT) status in young healthy individuals, either well-trained (T, n=10 (8 males)) or untrained (UT, n=11 (8 males)), affected muscle size and molecular markers with leg immobilization followed b…
View article: Does longer-muscle length resistance training cause greater longitudinal growth in humans?
Does longer-muscle length resistance training cause greater longitudinal growth in humans? Open
The purpose of this paper was to systematically review the literature regarding the effects of resistance training (RT) performed at longer-muscle length (LML) versus shorter-muscle length (SML) on proxy measurements for longitudinal hyper…
View article: Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy
Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy Open
We sought to examine how resistance exercise (RE), cycling exercise, and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation in humans. In the first study (1boutRE), younger adult men (n=8; 5±2 years of RE experience) per…
View article: A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training
A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training Open
The skeletal muscle proteome alterations to aging and resistance training have been reported in prior studies. However, conventional proteomics in skeletal muscle typically yields wide protein abundance ranges that mask the detection of lo…
View article: Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift
Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift Open
We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Untrained college-aged participants were randomized into HT (n = 18) or SQ (n = …
View article: The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults
The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults Open
Denervated myofibers and senescent cells are hallmarks of skeletal muscle aging. However, sparse research has examined how resistance training affects these outcomes. We investigated the effects of unilateral leg extensor resistance traini…
View article: Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation Open
Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multi-faceted approach to examine if acute and subchronic resistance tra…
View article: Proteolytic markers associated with a gain and loss of leg muscle mass with resistance training followed by high‐intensity interval training
Proteolytic markers associated with a gain and loss of leg muscle mass with resistance training followed by high‐intensity interval training Open
We recently reported that vastus lateralis (VL) cross‐sectional area (CSA) increases after 7 weeks of resistance training (RT, 2 days/week), with declines occurring following 7 weeks of subsequent treadmill high‐intensity interval training…
View article: Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift
Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift Open
Purpose We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Methods Untrained college-aged participants were randomized into HT or S…
View article: A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training
A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training Open
We examined the myofibrillar (MyoF) and non-myofibrillar (non-MyoF) proteomic profiles of the vastus lateralis (VL) muscle of younger (Y, 22±2 years old; n=5) and middle-aged participants (MA, 56±8 years old; n=6), and MA following eight w…
View article: The effects of resistance training to near failure on strength, hypertrophy, and motor unit adaptations in previously trained adults
The effects of resistance training to near failure on strength, hypertrophy, and motor unit adaptations in previously trained adults Open
Limited research exists examining how resistance training to failure affects applied outcomes and single motor unit characteristics in previously trained individuals. Herein, resistance‐trained adults (24 ± 3 years old, self‐reported resis…
View article: Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers
Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers Open
Although transcriptome profiling has been used in several resistance training studies, the associated analytical approaches seldom provide in-depth information on individual genes linked to skeletal muscle hypertrophy. Therefore, a seconda…
View article: Biomechanical, Anthropometric and Psychological Determinants of Barbell Bench Press Strength
Biomechanical, Anthropometric and Psychological Determinants of Barbell Bench Press Strength Open
The purpose of this study was to improve our understanding of the relative contributions of biomechanical, anthropometric, and psychological factors in explaining maximal bench press (BP) strength in a heterogeneous, resistance-trained sam…
View article: Peer Review #3 of "Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations (v0.1)"
Peer Review #3 of "Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations (v0.1)" Open
Background: Progressive overload is a principle of resistance training exercise program design that typically relies on increasing load to increase neuromuscular demand to facilitate further adaptations.However, little attention has been g…
View article: Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations
Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations Open
Background Progressive overload is a principle of resistance training exercise program design that typically relies on increasing load to increase neuromuscular demand to facilitate further adaptations. However, little attention has been g…
View article: Loaded inter-set stretch may selectively enhance muscular adaptations of the plantar flexors
Loaded inter-set stretch may selectively enhance muscular adaptations of the plantar flexors Open
The purpose of this study was to evaluate differences in changes in muscle strength and muscle thickness (MT) of the plantar flexor muscles between traditional resistance training (RT) involving passive rest and RT combined with inter-set …
View article: Slow and Steady, or Hard and Fast? A Systematic Review and Meta-Analysis of Studies Comparing Body Composition Changes between Interval Training and Moderate Intensity Continuous Training
Slow and Steady, or Hard and Fast? A Systematic Review and Meta-Analysis of Studies Comparing Body Composition Changes between Interval Training and Moderate Intensity Continuous Training Open
Purpose: To conduct a systematic review and multilevel meta-analysis of the current literature as to the effects of interval training (IT) vs moderate intensity continuous training (MICT) on measures of body composition, both on a whole-bo…
View article: Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives
Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives Open
Human muscle fibers are generally classified by myosin heavy chain (MHC) isoforms characterized by slow to fast contractile speeds. Type I, or slow-twitch fibers, are seen in high abundance in elite endurance athletes, such as long-distanc…
View article: Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum
Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum Open
Loading recommendations for resistance training are typically prescribed along what has come to be known as the “repetition continuum”, which proposes that the number of repetitions performed at a given magnitude of load will result in spe…
View article: Comparison of the effects of HIIT versus MICT on measures of body composition: A systematic review and meta-analysis of training outcomes
Comparison of the effects of HIIT versus MICT on measures of body composition: A systematic review and meta-analysis of training outcomes Open
The purpose of this paper is to conduct a systematic review and meta-analysis of the current literature as to the effects of SIT/HIIT versus MICT on measures of body composition, and to carry out meta-regression to determine the extent to …