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View article: High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space
High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space Open
Coenzyme F420 is involved in bioprocesses such as biosynthesis of antibiotics by streptomycetes, prodrug activation in Mycobacterium tuberculosis, and methanogenesis in archaea. F420-dependent enzymes also attract interest as biocatalysts …
View article: Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F <sub>420</sub> and Its Derivative 3PG-F <sub>420</sub>
Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F <sub>420</sub> and Its Derivative 3PG-F <sub>420</sub> Open
The microbial cofactor F 420 is crucial for processes like methanogenesis, antibiotics biosynthesis, drug resistance, and biocatalysis. Recently, a novel derivative of F 420 (3PG-F 420 ) was discovered, enabling the production and use of F…
View article: Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F<sub>420</sub> and its derivative 3PG-F<sub>420</sub>
Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F<sub>420</sub> and its derivative 3PG-F<sub>420</sub> Open
Coenzyme F 420 is a microbial redox cofactor that is increasingly used for biocatalytic applications. Recently, diversified biosynthetic routes to F 420 and the discovery of a derivative, 3PG-F 420 , were reported. 3PG-F 420 is formed via …
View article: Redox Coenzyme F <sub>420</sub> Biosynthesis in <i>Thermomicrobia</i> Involves Reduction by Stand-Alone Nitroreductase Superfamily Enzymes
Redox Coenzyme F <sub>420</sub> Biosynthesis in <i>Thermomicrobia</i> Involves Reduction by Stand-Alone Nitroreductase Superfamily Enzymes Open
Coenzyme F 420 is a redox cofactor of Archaea and Actinobacteria , as well as some Gram-negative bacteria. Its involvement in processes such as the biosynthesis of antibiotics, the degradation of xenobiotics, and asymmetric enzymatic reduc…
View article: Metabolic Pathway Rerouting in <i>Paraburkholderia rhizoxinica</i> Evolved Long-Overlooked Derivatives of Coenzyme F <sub>420</sub>
Metabolic Pathway Rerouting in <i>Paraburkholderia rhizoxinica</i> Evolved Long-Overlooked Derivatives of Coenzyme F <sub>420</sub> Open
Coenzyme F420 is a specialized redox cofactor with a negative redox potential. It supports biochemical processes like methanogenesis, degradation of xenobiotics, and the biosynthesis of antibiotics. Although well-studied in methanogenic ar…
View article: Metabolic pathway rerouting in<i>Paraburkholderia rhizoxinica</i>evolved long-overlooked derivatives of coenzyme F<sub>420</sub>
Metabolic pathway rerouting in<i>Paraburkholderia rhizoxinica</i>evolved long-overlooked derivatives of coenzyme F<sub>420</sub> Open
Coenzyme F 420 is a specialized redox cofactor with a highly negative redox potential. It supports biochemical processes like methanogenesis, degradation of xenobiotics or the biosynthesis of antibiotics. Although well-studied in methanoge…
View article: Fast, Continuous, and High-Throughput (Bio)Chemical Activity Assay for<i>N</i>-Acyl-<scp>l</scp>-Homoserine Lactone Quorum-Quenching Enzymes
Fast, Continuous, and High-Throughput (Bio)Chemical Activity Assay for<i>N</i>-Acyl-<span>l</span>-Homoserine Lactone Quorum-Quenching Enzymes Open
Quorum sensing, the bacterial cell-cell communication by small molecules, controls important processes such as infection and biofilm formation. Therefore, it is a promising target with several therapeutic and technical applications besides…