Daniel Leino
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View article: Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice
Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice Open
Thrombin promotes the proliferation and function of CD8+ T cells. To test if thrombin prevents exhaustion and sustains antiviral T cell activity during chronic viral infection, we depleted the thrombin-precursor prothrombin to 10% of norma…
View article: Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice
Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice Open
Thrombin promotes the proliferation and function of CD8+ T cells. To test if thrombin prevents exhaustion and sustains antiviral T cell activity during chronic viral infection, we depleted the thrombin-precursor prothrombin to 10% of norma…
View article: Transcriptome analysis in acute gastrointestinal graft-<i>versus</i> host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease
Transcriptome analysis in acute gastrointestinal graft-<i>versus</i> host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease Open
We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute acute GI graft-versus-host disease (GvHD) to study differential gene expressions…
View article: T‐cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients
T‐cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients Open
Background Late acute cellular rejection (ACR) is associated with donor‐specific antibodies (DSA) development, chronic rejection, and allograft loss. However, accurate predictors of late ACR treatment response are lacking. ACR is primarily…
View article: Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation
Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation Open
Previous studies suggested that contact pathway factors drive thrombosis in mechanical circulation. We used a rabbit model of veno-arterial extracorporeal circulation (VA-ECMO) to evaluate the role of factors XI and XII in ECMO-associated …
View article: ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition
ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition Open
ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented in case reports…
View article: Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms
Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms Open
Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing appr…
View article: Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency
Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency Open
Collectively, these data suggest a model that rapamycin rescues BSEP-deficient phenotypes by prompting alternative transporters to excrete bile salts; multidrug resistance protein 1 is a candidate for such an alternative transporter. (Hepa…
View article: Isolated Upper Extremity Posttransplant Lymphoproliferative Disorder in a Child
Isolated Upper Extremity Posttransplant Lymphoproliferative Disorder in a Child Open
Posttransplant lymphoproliferative disorder (PTLD) is a well-described complication of solid organ and bone marrow transplants. The most common presentation is intra-abdominal lymphadenopathy or single or multiple intraparenchymal masses i…