Daniel M. Aebersold
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View article: A dual-layer quality assurance approach leveraging dose prediction for efficient review of automated contours of organs at risk in the brain in radiotherapy
A dual-layer quality assurance approach leveraging dose prediction for efficient review of automated contours of organs at risk in the brain in radiotherapy Open
View article: Evaluation of compartmentalized automatic segmentation for definition of the GTV in glioblastoma radiotherapy
Evaluation of compartmentalized automatic segmentation for definition of the GTV in glioblastoma radiotherapy Open
The Neosoma Glioma model generates clinically useful postoperative GTV segmentations, with geometric performance comparable to expert variability and dosimetric equivalence to consensus contours. It reduces contouring time by over 50%, ena…
View article: A comparative performance analysis of regular expressions and a large language model-based approach to extract the BI-RADS score from radiological reports
A comparative performance analysis of regular expressions and a large language model-based approach to extract the BI-RADS score from radiological reports Open
Background Different natural language processing (NLP) techniques have demonstrated promising results for data extraction from radiological reports. Both traditional rule-based methods like regular expressions (Regex) and modern large lang…
View article: Radiological response assessment after stereotactic body radiotherapy for spine metastases using magnetic resonance imaging: a systematic review
Radiological response assessment after stereotactic body radiotherapy for spine metastases using magnetic resonance imaging: a systematic review Open
View article: Implementing a Resource-Light and Low-Code Large Language Model System for Information Extraction from Mammography Reports: A Pilot Study
Implementing a Resource-Light and Low-Code Large Language Model System for Information Extraction from Mammography Reports: A Pilot Study Open
Large language models (LLMs) have been successfully used for data extraction from free-text radiology reports. Most current studies were conducted with LLMs accessed via an application programming interface (API). We evaluated the feasibil…
View article: Treatment approaches for non-metastatic small cell bladder cancer: a meta-analysis of reconstructed Kaplan–Meier curves
Treatment approaches for non-metastatic small cell bladder cancer: a meta-analysis of reconstructed Kaplan–Meier curves Open
View article: A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy
A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy Open
The framework provides a robust method for validating automatic segmentation models in radiotherapy. However, establishing standardized benchmarks and consensus guidelines within the radiotherapy community remains essential for proper clin…
View article: A randomized safety study of tolerance to table rotation in dynamic trajectory radiotherapy in healthy volunteers
A randomized safety study of tolerance to table rotation in dynamic trajectory radiotherapy in healthy volunteers Open
View article: Cone-beam computed tomography-based online adaptive radiotherapy of esophageal cancer in the neoadjuvant setting: Dosimetric analysis, toxicity and treatment response
Cone-beam computed tomography-based online adaptive radiotherapy of esophageal cancer in the neoadjuvant setting: Dosimetric analysis, toxicity and treatment response Open
This study confirms dosimetric improvements and high pMR rates with manageable toxicity following neoadjuvant CBCT-based oART in EC, suggesting oART could enhance treatment outcomes and support non-operative strategies for selected patient…
View article: A Comparative Performance Analysis of Regular Expressions and an LLM-Based Approach to Extract the BI-RADS Score from Radiological Reports
A Comparative Performance Analysis of Regular Expressions and an LLM-Based Approach to Extract the BI-RADS Score from Radiological Reports Open
Background Different Natural Language Processing (NLP) techniques have demonstrated promising results for data extraction from radiological reports. Both traditional rule-based methods like regular expressions (Regex) and modern Large Lang…
View article: Reconsideration of the resection strategy of eloquent brain metastasis in the era of postoperative stereotactic radiotherapy: a comparative analysis with non-eloquent metastasis
Reconsideration of the resection strategy of eloquent brain metastasis in the era of postoperative stereotactic radiotherapy: a comparative analysis with non-eloquent metastasis Open
Purpose To decrease the recurrence rate after complete resection of a brain metastasis, removal of a surgical safety margin is advocated. This is not always feasible when resecting a metastasis in an eloquent location. We aimed to assess t…
View article: Dose-intensified SBRT for vertebral oligometastases: results from a prospective clinical trial
Dose-intensified SBRT for vertebral oligometastases: results from a prospective clinical trial Open
Dose-intensified SBRT for vertebral oligometastases is effective and safe, even in high-risk patients with epidural or paraspinal involvement.
View article: Large Language Models for Supporting Clear Writing and Detecting Spin in Randomized Controlled Trials in Oncology
Large Language Models for Supporting Clear Writing and Detecting Spin in Randomized Controlled Trials in Oncology Open
Importance Accurate interpretation of randomized controlled trial (RCT) results is essential for guiding clinical practice in oncology. Reporting “spin” can misrepresent treatment efficacy, potentially leading to suboptimal clinical decisi…
View article: Implementing a Resource-Light and Low-Code Large Language Model System for Information Extraction from Mammography Reports: A Case Study
Implementing a Resource-Light and Low-Code Large Language Model System for Information Extraction from Mammography Reports: A Case Study Open
Background Large Language Models (LLMs) have been successfully used to extract structured data from free-text radiology reports. Most of current studies were conducted with private models accessed via Application Programming Interface (API…
View article: Salvage Radiotherapy Following Nonradiotherapy Ablative Techniques for Primary Prostate Cancer: A Systematic Review and Meta-analysis
Salvage Radiotherapy Following Nonradiotherapy Ablative Techniques for Primary Prostate Cancer: A Systematic Review and Meta-analysis Open
SRT following NRAI for localized prostate cancer has low toxicity rates, particularly following cryotherapy, and reasonable biochemical control. Despite these findings, short follow-up and variability in treatments for patients with varyin…
View article: Comparative Evaluation of a Medical Large Language Model in Answering Real-World Radiation Oncology Questions: Multicenter Observational Study
Comparative Evaluation of a Medical Large Language Model in Answering Real-World Radiation Oncology Questions: Multicenter Observational Study Open
Background Large language models (LLMs) hold promise for supporting clinical tasks, particularly in data-driven and technical disciplines such as radiation oncology. While prior evaluation studies have focused on examination-style settings…
View article: Table S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Differential expression analysis of the GTL-16 and EBC-1 transcriptomics data.
View article: Figure S6 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S6 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
GART protein expression upon MAPK and PI3K targeting: GART protein levels in untreated GTL-16 and EBC-1 cells and after MAPK (AZD6244) and PI3K (LY294002) pathways inhibition. ß Actin was used as a loading control.
View article: Figure S6 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S6 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
GART protein expression upon MAPK and PI3K targeting: GART protein levels in untreated GTL-16 and EBC-1 cells and after MAPK (AZD6244) and PI3K (LY294002) pathways inhibition. ß Actin was used as a loading control.
View article: Table S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Summary of the significance analysis for the survival analyses.
View article: Figure S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Suppementary metabolomics data: (A) Heat map determining top hits of metabolite ions in all cell lines at 24 hrs time-point post METi (|log2FC| > 0.5; adj.P value < 0.01). (B) Differences in metabolite ions (dots) abundance in METi-…
View article: Table S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Basic statistics of the downloaded TCGA data.
View article: Table S1 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S1 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Differential abundance analysis and ion annotation matches for non-targeted metabolomics measurements.
View article: Table S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Basic statistics of the downloaded TCGA data.
View article: Figure S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Supplementations with glutamine, serine, and folic acid: (A) Proliferation of GTL-16 and EBC-1 cells upon supplementation with glutamine, serine or folic acid. (B) Apoptosis (caspase-3 activation) in GTL-16 and EBC-1 cells upon supplementa…
View article: Figure S5 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S5 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
GART and E2F1 mRNA levels following METi combined with IR: mRNA levels of GART (left) and E2F1 (right) following METi (50nM, 24 hr), IR (10 Gy, 1 hr) and their combination in GTL-16 and EBC-1 cells.
View article: Table S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Differential expression analysis of the GTL-16 and EBC-1 transcriptomics data.
View article: Figure S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Supplementations with glutamine, serine, and folic acid: (A) Proliferation of GTL-16 and EBC-1 cells upon supplementation with glutamine, serine or folic acid. (B) Apoptosis (caspase-3 activation) in GTL-16 and EBC-1 cells upon supplementa…
View article: Table S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Table S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Summary of the significance analysis for the survival analyses.
View article: Figure S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Figure S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network Open
Supplementations with nucleosides and hypoxanthine: (A) Proliferation of GTL-16 and EBC-1 cells upon supplementation with nucleosides or hypoxanthine. (B) Apoptosis (caspase-3 activation) in GTL-16 and EBC-1 upon supplementation with nucle…