Daniel M. Foulkes
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View article: Stable topical application of antimicrobials using plumbing rings in an<i>ex vivo</i>porcine corneal infection model
Stable topical application of antimicrobials using plumbing rings in an<i>ex vivo</i>porcine corneal infection model Open
Microbial keratitis (MK) is a substantial cause of clinical blindness worldwide. Pseudomonas aeruginosa is an opportunistic gram-negative bacterium and is the leading cause of MK. Infection models are vital tools in understanding host-path…
View article: An Optimized Porcine Corneal Ex Vivo Model Using Plumbing Rings and Medical Adhesive for Controlled Localized Infection with Topical Treatments v1
An Optimized Porcine Corneal Ex Vivo Model Using Plumbing Rings and Medical Adhesive for Controlled Localized Infection with Topical Treatments v1 Open
Infection models are essential tools for understanding host-pathogen interactions and developing noveltherapies. Ex vivo infection models offer significant ethical and practical advantages, enabling more accurate and physiologically releva…
View article: Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity. Open
The authors of the original article "Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity" (Biochem. J. (2022) 479 (24): 2511–2527; https://doi.org/10.1042/BCJ20220527) would like to …
View article: Impact of fluoroquinolones and aminoglycosides on <i>P. aeruginosa</i> virulence factor production and cytotoxicity
Impact of fluoroquinolones and aminoglycosides on <i>P. aeruginosa</i> virulence factor production and cytotoxicity Open
The opportunistic pathogen Pseudomonas aeruginosa is one of leading causes of disability and mortality worldwide and the world health organisation has listed it with the highest priority for the need of new antimicrobial therapies. P. aeru…
View article: P-18 Impact of fluoroquinolones and aminoglycosides on P<i>. aeruginosa</i> virulence factor production and cytotoxicity
P-18 Impact of fluoroquinolones and aminoglycosides on P<i>. aeruginosa</i> virulence factor production and cytotoxicity Open
*Correspondence - Stephen Kaye: [email protected] INTRODUCTION: Pseudomonas aeruginosa injects toxins, ExoS or ExoU, into host cells via the type III secretion system (T3SS) which destroy cells and help evade the immune system. Firs…
View article: A phospholipase assay screen identifies synergistic inhibitors of the <i>P. aeruginosa</i> toxin ExoU
A phospholipase assay screen identifies synergistic inhibitors of the <i>P. aeruginosa</i> toxin ExoU Open
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of disability and mortality worldwide and the World Health Organisation has listed it with the highest priority for the need of new therapies. P. aeruginosa strains that …
View article: A pipeline to evaluate inhibitors of the <i>Pseudomonas aeruginosa</i> exotoxin U
A pipeline to evaluate inhibitors of the <i>Pseudomonas aeruginosa</i> exotoxin U Open
Pseudomonas aeruginosa has recently been highlighted by the World Health Organisation (WHO) as a major threat with high priority for the development of new therapies. In severe P. aeruginosa infections, the phospholipase activity of the ty…
View article: Pseudomonas aeruginosa Toxin ExoU as a Therapeutic Target in the Treatment of Bacterial Infections
Pseudomonas aeruginosa Toxin ExoU as a Therapeutic Target in the Treatment of Bacterial Infections Open
The opportunistic pathogen Pseudomonas aeruginosa employs the type III secretion system (T3SS) and four effector proteins, ExoS, ExoT, ExoU, and ExoY, to disrupt cellular physiology and subvert the host’s innate immune response. Of the eff…
View article: Comb-like dextran copolymers: A versatile strategy to coat highly porous MOF nanoparticles with a PEG shell
Comb-like dextran copolymers: A versatile strategy to coat highly porous MOF nanoparticles with a PEG shell Open
View article: Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)
Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019) Open
International audience
View article: Biochemical analysis of Tribbles 2 pseudokinase using repurposed kinase inhibitors
Biochemical analysis of Tribbles 2 pseudokinase using repurposed kinase inhibitors Open
View article: Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells Open
Covalent EGFR family inhibitors bind to and induce the degradation of the pseudokinase TRIB2 to kill cancer cells.
View article: Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase
Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase Open
ONE SENTENCE SUMMARY A Tribbles 2 pseudokinase small molecule screen led to the identification of known EGFR/HER2 inhibitors that alter the stability of TRIB2 in vitro and lead to rapid on-target degradation of TRIB2 in human cancer cells.…
View article: Pseudokinases: Update on Their Functions and Evaluation as New Drug Targets
Pseudokinases: Update on Their Functions and Evaluation as New Drug Targets Open
The pseudokinase complement of the human kinase superfamily consists of approximately 60 signaling proteins, which lacks one or more of the amino acids typically required to correctly align ATP and metal ions, and phosphorylate protein sub…