Daniel Frey
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View article: Diphtheria toxin T-domain as a tool for inducing lipid vesicle fusion
Diphtheria toxin T-domain as a tool for inducing lipid vesicle fusion Open
Membrane fusion is fundamental for many biological processes, including subcellular compartmentalization, cell growth, and exo- and endocytosis. It also plays a key role in the fabrication of artificial membrane structures, particularly ve…
View article: Mapping water, sanitation and hygiene achievements to prosperity, stability, and resilience outcomes
Mapping water, sanitation and hygiene achievements to prosperity, stability, and resilience outcomes Open
About 3ieThe International Initiative for Impact Evaluation (3ie) develops evidence on how to effectively transform the lives of the poor in low-and middle-income countries.Established in 2008, we offer comprehensive support and a diversit…
View article: Targeting virulence regulation to disarm <i>Acinetobacter baumannii</i> pathogenesis
Targeting virulence regulation to disarm <i>Acinetobacter baumannii</i> pathogenesis Open
The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional r…
View article: A Coiled-Coil-Based Design Strategy for the Thermostabilization of G-Protein-Coupled Receptors
A Coiled-Coil-Based Design Strategy for the Thermostabilization of G-Protein-Coupled Receptors Open
The most common methods for generating crystallizable GPCRs are scanning alanine mutagenesis and fusion to crystallization-facilitating partner proteins. The major goal of our work was to create a new GPCR tool that would provide receptor …
View article: Greenhead (Tabanus nigrovittatus) <i>Wolbachia</i> and Its Microbiome: A Preliminary Study
Greenhead (Tabanus nigrovittatus) <i>Wolbachia</i> and Its Microbiome: A Preliminary Study Open
Tabanus nigrovittatus greenhead populations contain two supergroups of Wolbachia endosymbionts, members of supergroups A and B. Analysis of the greenhead microbiome using next-generation sequencing revealed that the majority of bacterial s…
View article: Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C
Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C Open
A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray …
View article: Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations Open
Tight regulation of kinesin activity is crucial and malfunction is linked to neurological diseases. Point mutations in the KIF21A gene cause congenital fibrosis of the extraocular muscles type 1 (CFEOM1) by disrupting the autoinhibitory in…
View article: Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth
Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth Open
Centrioles are fundamental and evolutionarily conserved microtubule-based organelles whose assembly is characterized by microtubule growth rates that are orders of magnitude slower than those of cytoplasmic microtubules. Several centriolar…