Daniel M. Keenan
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View article: Method for biological purification
Method for biological purification Open
An apparatus is disclosed for containing a microorganism culture in an active exponential growth and delivering a supply of microorganisms to an environment containing wastes for bio-augmenting the biodegradation of the wastes. The apparat…
View article: Regulation and adaptation of endocrine axes at high altitude
Regulation and adaptation of endocrine axes at high altitude Open
As a model of extreme conditions, eight healthy women, part of a 40-member Nepal mountain-climbing expedition, were monitored for dynamic endocrine adaptations. Endocrine measurements were made at frequent intervals over a 6–10-h period at…
View article: Dynamic Pituitary–Adrenal Interactions in the Critically Ill after Cardiac Surgery
Dynamic Pituitary–Adrenal Interactions in the Critically Ill after Cardiac Surgery Open
Context Patients with critical illness are thought to be at risk of adrenal insufficiency. There are no models of dynamic hypothalamic–pituitary–adrenal (HPA) axis function in this group of patients and thus current methods of diagnosis ar…
View article: A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol
A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol Open
Quantification of disturbances in glucose-insulin homeostasis has been the cornerstone of appraising insulin resistance and detecting early-stage diabetes. Metabolic homeostasis arises from feedback and feed-forward interactions among (at …
View article: A prognostic signature for lower-grade gliomas based on expression of long noncoding RNAs
A prognostic signature for lower-grade gliomas based on expression of long noncoding RNAs Open
Diffuse low-grade and intermediate-grade gliomas (together known as lower-grade gliomas, WHO grade II and III) develop in the supporting glial cells of brain and are the most common types of primary brain tumor. Despite a better prognosis …
View article: Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification
Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification Open
Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland …
View article: Stochastic Modeling of Mouse Motor Activity under Deep Brain Stimulation: The Extraction of Arousal Information
Stochastic Modeling of Mouse Motor Activity under Deep Brain Stimulation: The Extraction of Arousal Information Open
In the present paper, we quantify, with a rigorous approach, the nature of motor activity in response to Deep Brain Stimulation (DBS), in the mouse. DBS is currently being used in the treatment of a broad range of diseases, but its underly…