Daniel Malouli
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View article: HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36
HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 Open
Human cytomegalovirus (HCMV) establishes latency in CD34 + hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation. We demonstrate that the Notch signaling pathway, a key regulator of stem…
View article: Mapping of species-specific determinants enabling the induction of MHC-E and MHC-II-restricted CD8+ T cells by cytomegalovirus 4406
Mapping of species-specific determinants enabling the induction of MHC-E and MHC-II-restricted CD8+ T cells by cytomegalovirus 4406 Open
Description Infection of rhesus macaques (RM) with rhesus cytomegalovirus (RhCMV) elicits MHC-I restricted CD8 T cell responses whereas RhCMV deleted for homologs of HCMV UL128, UL130 and UL146 induces MHC-II and MHC-E restricted CD8 T cel…
View article: Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34 <sup>+</sup> hematopoietic progenitor cells
Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34 <sup>+</sup> hematopoietic progenitor cells Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the lifetime of the host due to the establishment of latency. HCMV encodes four putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. A defi…
View article: Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34<sup>+</sup>Hematopoietic Progenitor Cells
Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34<sup>+</sup>Hematopoietic Progenitor Cells Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the lifetime of the host due in part to the establishment of latency in CD34 + hematopoietic progenitor cells (HPCs) and CD14 + monocytes. HCMV encodes four put…
View article: Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV
Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV Open
Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to el…
View article: The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed …
View article: Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity Open
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function in an animal mode…
View article: A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes
A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform design of a maternal vaccine remain elusive. Here, we characterized the outcome of primary rhesus…
View article: Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 <sup>+</sup> T cells
Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 <sup>+</sup> T cells Open
Rhesus cytomegalovirus (RhCMV) vectors elicit major histocompatibility complex (MHC)–E–restricted CD8 + T cells that stringently control simian immunodeficiency virus (SIV) in rhesus macaques. These responses require deletion of eight RhCM…
View article: Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge Open
An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident ef…
View article: CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E
CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E Open
The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/CD94 receptors on NK cells and tumor-infiltrating T cells. To inv…
View article: Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity Open
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro , but their role in infection and pathogenesis is unknown. To examine the in vivo function of vFcγRs in anima…
View article: Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model Open
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that mat…
View article: Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases w…
View article: HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34 <sup>+</sup> hematopoietic progenitor cells
HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34 <sup>+</sup> hematopoietic progenitor cells Open
Human cytomegalovirus (HCMV) is a species-specific virus that establishes a persistent/latent infection in CD34 + hematopoietic progenitor cells (HPCs). The ability of HCMV to reactivate from latency is exquisitely linked to changes in cel…
View article: The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques
The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques Open
Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of neonatal neurological impairment but essential virological determinants of transplacental CMV transmission remain unclear. The pentameric complex (PC), composed…
View article: Rhesus macaque cytomegalovirus deploys viral Fcγ receptors to evade antibody-mediated cellular immunity
Rhesus macaque cytomegalovirus deploys viral Fcγ receptors to evade antibody-mediated cellular immunity Open
Cytomegalovirus (CMV) is a top priority in vaccine development due to the high burden of disease in immunocompromised populations and congenitally infected infants. Evidence suggests that CMV-specific Fc-mediated antibody effector response…
View article: Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model Open
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that mat…
View article: Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases w…
View article: Late gene expression–deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV
Late gene expression–deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV Open
Rhesus cytomegalovirus-based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory-based (EM-biased) CD8+ T cells re…
View article: Myeloid cell tropism enables MHC-E–restricted CD8 <sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine
Myeloid cell tropism enables MHC-E–restricted CD8 <sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine Open
The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This vaccine e…
View article: Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy Open
Viral peptide is key to T cell priming Simian immunodeficiency virus (SIV) vaccines containing a strain 68-1 rhesus cytomegalovirus (RhCMV) vector elicit strong CD8 + T cell responses that can control and clear SIV infections. The SIV pept…
View article: Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy Open
Eight RhCMV gene products control induction of unconventionally restricted CD8 + T cells and RhCMV/SIV vaccine efficacy.
View article: In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome Open
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaque…
View article: Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy Open
Strain 68-1 rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens elicit CD8 + T cells that recognize peptide epitopes presented by major histocompatibility complex (MHC)-II and MHC-E molecules, ins…
View article: Cytomegaloviral determinants of CD8<sup>+</sup>T cell programming and RhCMV/SIV vaccine efficacy
Cytomegaloviral determinants of CD8<sup>+</sup>T cell programming and RhCMV/SIV vaccine efficacy Open
Simian immunodeficiency virus (SIV) insert-expressing, 68-1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8 + T cell responses, but the basis of these unconve…
View article: <i>In vitro</i>and<i>in vivo</i>characterization of a recombinant rhesus cytomegalovirus containing a complete genome
<i>In vitro</i>and<i>in vivo</i>characterization of a recombinant rhesus cytomegalovirus containing a complete genome Open
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaque…
View article: Characterization of a live-attenuated HCMV-based vaccine platform
Characterization of a live-attenuated HCMV-based vaccine platform Open
Vaccines based on cytomegalovirus (CMV) demonstrate protection in animal models of infectious disease and cancer. Vaccine efficacy is associated with the ability of CMV to elicit and indefinitely maintain high frequencies of circulating ef…