Daniel Manoil
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Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis Open
Aim To examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessin…
A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections Open
Enterococcus faecalis , a non-oral nosocomial pathogen, intriguingly ranks among the most frequently retrieved species from polymicrobial infections of dental root canals. This review integrates findings from the latest omics approaches, a…
Candida albicans colonization on CAD-CAM denture resin surface Open
Understanding the impact of fabrication methods on microbial colonization is essential for improving denture hygiene and patient outcomes. Dentists and prosthodontists should consider these findings when selecting materials for patients at…
Microbial diagnostics in periodontal diseases Open
Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding of subgingival community dynamics. Certain pathobionts can orchestrate the establishmen…
Profiling Antibiotic Susceptibility among Distinct Enterococcus faecalis Isolates from Dental Root Canals Open
Enterococcus faecalis, a leading multi-resistant nosocomial pathogen, is also the most frequently retrieved species from persistently infected dental root canals, suggesting that the oral cavity is a possible reservoir for resistant strain…
Gram-negative quorum sensing signalling enhances biofilm formation and virulence traits in gram-positive pathogen <i>Enterococcus faecalis</i> Open
Acyl-homoserine lactones (AHLs) are typical quorum-sensing molecules of gram-negative bacteria. Recent evidence suggests that AHLs may also affect gram-positives, although knowledge of these interactions remains scarce. Here, we assessed t…
Editorial: The interplay between the oral Microbiota and rheumatoid arthritis Open
EDITORIAL article Front. Oral. Health, 08 November 2022Sec. Oral Infections and Microbes https://doi.org/10.3389/froh.2022.1055482
Photo-oxidative stress response and virulence traits are co-regulated in E. faecalis after antimicrobial photodynamic therapy Open
Knowledge of photo-oxidative stress responses in bacteria that survive antimicrobial photodynamic therapy (aPDT) is scarce. Whereas aPDT is attracting growing clinical interest, subsequent stress responses are crucial to evaluate as they m…
View article: Identification of Type-H-like Blood Vessels in a Dynamic and Controlled Model of Osteogenesis in Rabbit Calvarium
Identification of Type-H-like Blood Vessels in a Dynamic and Controlled Model of Osteogenesis in Rabbit Calvarium Open
Angiogenesis and bone regeneration are closely interconnected processes. Whereas type-H blood vessels are abundantly found in the osteogenic zones during endochondral long bone development, their presence in flat bones’ development involvi…
Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology Open
The genus Veillonella comprises 16 characterized species, among which eight are commonly found in the human oral cavity. The high abundance of Veillonella species in the microbiome of both supra- and sub-gingival biofilms, and their interd…
Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges Open
The oral cavity is the habitat of several hundreds of microbial taxa that have evolved to coexist in multispecies communities in this unique ecosystem. By contrast, the internal tissue of the tooth, i.e., the dental pulp, is a physiologica…
Pre-Treat Xenogenic Collagenous Blocks of Bone Substitutes with Saline Facilitate Their Manipulation and Guarantee High Bone Regeneration Rates, Qualitatively and Quantitatively Open
Deproteinized bovine bone mineral particles embedded in collagen (DBBM-C) are widely used for bone regenerations with excellent, albeit sometimes variable clinical outcomes. Clinicians usually prepare DBBM-C by mixing with blood. Replacing…
Healthcare Challenges and Future Solutions in Dental Practice: Assessing Oral Antibiotic Resistances by Contemporary Point-Of-Care Approaches Open
Antibiotic resistance poses a global threat, which is being acknowledged at several levels, including research, clinical implementation, regulation, as well as by the World Health Organization. In the field of oral health, however, the iss…
Microbial Community-Driven Etiopathogenesis of Peri-Implantitis Open
Osseointegrated dental implants are a revolutionary tool in the armament of reconstructive dentistry, employed to replace missing teeth and restore masticatory, occlusal, and esthetic functions. Like natural teeth, the orally exposed part …
Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis Open
Background Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential correlations betw…
A Systematic Review of the Root Canal Microbiota Associated with Apical Periodontitis: Lessons from Next‐Generation Sequencing Open
Next‐generation sequencing (NGS) has now been applied for a decade to characterize the microbiota composition of infected dental root canals associated with apical periodontitis. Here, the study aims at systematically and critically review…
Root Microbiota in Primary and Secondary Apical Periodontitis Open
Apical periodontitis is an inflammatory disease of the dental periradicular tissues triggered by bacteria colonizing necrotic root canals. Primary apical periodontitis results from the microbial colonization of necrotic pulp tissues. Secon…
Oxidative Stress in Bacteria Measured by Flow Cytometry Open
The CellROX® Deep Red flow cytometry kit (Life technologies) has been developed for the detection of oxidative stress in mammalian cells.It combines a ROS sensitive fluorophore (CellROX® Deep Red) and a "viability" dye (SYTOX® Blue) to all…
Blue light-mediated antimicrobial photodynamic therapy on oral pathogens Open
Antimicrobial photodynamic therapy (aPDT) relies on the light activation of a photosensitizer to generate ROS that inactivate bacteria. This thesis investigated the efficiency of three blue light-absorbing photosensitizers, curcumin, Eosin…