Daniel M. Marko
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View article: Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in Obesity
Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in Obesity Open
Elevated blood glucose, insulin, and insulin resistance are associated with obesity and type 2 diabetes (T2D). High blood insulin levels blunt lipolysis and promote lipogenesis, and thus weight gain. Intermittent fasting (IF) has emerged a…
View article: GDF15 links adipose tissue lipolysis with anxiety
GDF15 links adipose tissue lipolysis with anxiety Open
Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels and can be alleviated by a peripherally restric…
View article: Microbiota protect against frailty and loss of skeletal muscle, and maintain inflammatory tone during aging in mice
Microbiota protect against frailty and loss of skeletal muscle, and maintain inflammatory tone during aging in mice Open
Germ-free mice had increased frailty, lower muscle mass, and lower circulating inflammatory monocytes. Therefore, lower systemic inflammation coincided with worse frailty and muscle loss. Microbial colonization decreased frailty, restored …
View article: Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice Open
This study, in vivo and in vitro, investigated the role of brain‐derived neurotrophic factor (BDNF) in skeletal muscle adaptations to aerobic exercise. BDNF is a contraction‐induced protein that may play a role in muscle adaptations to aer…
View article: 9179 Type 2 Diabetes Alters Metabolic Fuel Selection During Intermittent Fasting
9179 Type 2 Diabetes Alters Metabolic Fuel Selection During Intermittent Fasting Open
Disclosure: M.O. Conn: None. D.M. Marko: None. J.D. Schertzer: None. Type 2 Diabetes Alters Metabolic Fuel Selection During Intermittent Fasting Diabetes is characterized by elevated blood glucose resulting from defective insulin secretion…
View article: Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes Open
Gut microbiota influence host immunity and metabolism during obesity. Bacterial sensors of the innate immune system relay signals from specific bacterial components (i.e., postbiotics) that can have opposing outcomes on host metabolic infl…
View article: Rapid Prototyping of Automotive Magnetic Positioning Systems
Rapid Prototyping of Automotive Magnetic Positioning Systems Open
Magnetic position and orientation systems offer the advantages of contactless sensing, high precision, robustness and low cost.They are heavily employed in automotive and industrial applications.The standard development process of such sys…
View article: Kinase inhibitors for cancer alter metabolism, blood glucose, and insulin
Kinase inhibitors for cancer alter metabolism, blood glucose, and insulin Open
Small molecule kinase inhibitors (SMKIs) are a class of therapeutic drugs that target protein kinases in diseases such as cancer. SMKIs are often designed to inhibit kinases involved in cell proliferation, but these drugs alter cell metabo…
View article: Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle
Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle Open
Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue are two mechanisms implicated in energy expenditure. Here, we investi…
View article: Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice
Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Open
The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ i…
View article: SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice
SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Open
Summary The DBA/2J (D2) mdx mouse has emerged as a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA) f…
View article: Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling
Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling Open
Perturbations in metabolism results in the accumulation of beta-amyloid peptides, which is a pathological feature of Alzheimer’s disease. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate limiting enzyme responsible…
View article: Slithering Through the Bone Marrow: Loiasis in a Patient With Human T-Cell Leukemia Virus-1-Associated Adult T-Cell Lymphoma
Slithering Through the Bone Marrow: Loiasis in a Patient With Human T-Cell Leukemia Virus-1-Associated Adult T-Cell Lymphoma Open
Loiasis is a filarial disease endemic to areas of Central and West Africa. We present a case of Loa loa microfilaremia in a patient with HTLV-1-related adult T-cell lymphoma. This case may suggest the possible role of cellular immunity in …
View article: Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk
Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk Open
With the world’s population aging at a rapid rate, the prevalence of Alzheimer’s disease (AD) has significantly increased. These statistics are alarming given recent evidence that a third of dementia cases may be preventable. The role of l…
View article: Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells
Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells Open
Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 can result in GLUT4 translocation and increased glucose uptake through AMPK activati…
View article: P3‐155: ROLE OF ACUTE EXERCISE‐INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1
P3‐155: ROLE OF ACUTE EXERCISE‐INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1 Open
Perturbations in metabolism results in the accumulation of beta-amyloid, which is a pathological feature of Alzheimer's Disease (AD) (1). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate limiting enzyme in the path…
View article: Rac1 supports muscle glucose uptake independently of Akt
Rac1 supports muscle glucose uptake independently of Akt Open
Insulin plays a major role in the regulation of glucose homeostasis. Insulin-stimulated glucose uptake in skeletal muscle is achieved by increased translocation of intracellular stored GLUT4 glucose transporters to the plasma membrane thro…
View article: Impact of Cyanidin-based anthocyanins on Ros Levels in human colon carcinoma cells
Impact of Cyanidin-based anthocyanins on Ros Levels in human colon carcinoma cells Open
Anthocyanins are able to scavenge ROS and thus protect against free radicals and cell oxidation. The nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) is considered as a key sensor for cellular ROS. In its active form Nrf2 transloc…
View article: Cytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall.
Cytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall. Open
Human granulocytic anaplasmosis is a rare, tick-borne infectious disease caused by Anaplasma phagocytophilum. Herein, we report a rare case of human granulocytic anaplasmosis associated with cytopenias and clonal expansion of gamma/delta T…
View article: Anthocyanin production platform using plant suspension cultures as green factories
Anthocyanin production platform using plant suspension cultures as green factories Open
Anthocyanins are water-soluble pigments that colour the fruit and flowers of many plants. More than 635 different anthocyanins have been identified, distinguished by methylation, glycosylation and acylation with both aliphatic and aromatic…