Daniel McFeely
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View article: Data for Biguanide iridium(III) complexes with potent antimicrobial activity
Data for Biguanide iridium(III) complexes with potent antimicrobial activity Open
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and…
View article: Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity Open
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and…
View article: Combatting AMR: photoactivatable ruthenium(<scp>ii</scp>)-isoniazid complex exhibits rapid selective antimycobacterial activity
Combatting AMR: photoactivatable ruthenium(<span>ii</span>)-isoniazid complex exhibits rapid selective antimycobacterial activity Open
The Ru(ii) complex,cis-[Ru(bpy)2(INH)2]2+is inactive in the dark but highly active towards mycobacteria on photoactivation with visible light when it releases the antituberculosis drug isoniazid (INH).
View article: CCDC 1474453: Experimental Crystal Structure Determination
CCDC 1474453: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth
The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth Open
PknB is an essential serine/threonine protein kinase required for mycobacterial cell division and cell-wall biosynthesis. Here we demonstrate that overexpression of the external PknB_PASTA domain in mycobacteria results in delayed regrowth…