Daniel Millard
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View article: 1271 Development of a functional cardiotoxicity assay for evaluating the safety of cell therapies
1271 Development of a functional cardiotoxicity assay for evaluating the safety of cell therapies Open
Background Chimeric antigen receptor (CAR) T cells have emerged as a promising treatment for several cancers. However, CAR T cell therapy is currently hampered by off-tumor toxicity that can manifest in multiple forms and can offset improv…
View article: 441 Development of a repeated challenge potency assay for evaluation of immune cell-mediated cytotoxicity in vitro
441 Development of a repeated challenge potency assay for evaluation of immune cell-mediated cytotoxicity in vitro Open
Background The development of immunotherapies relies on the use of in vitro potency assays—which are key for understanding complex interactions between immune (effector) cells and cancer (target) cells. Although a variety of in vitro assay…
View article: Development of a liquid tumor potency assay for evaluation of immune cell-mediated cytotoxicity in vitro
Development of a liquid tumor potency assay for evaluation of immune cell-mediated cytotoxicity in vitro Open
The development of immunotherapies relies on the use of in vitro potency assays—which are key for understanding complex interactions between immune (effector) cells and cancer (target) cells—to evaluate the function, specificity, and sensi…
View article: 380 Development and characterization of a CAR T cell potency assay with 3D cancer spheroid models
380 Development and characterization of a CAR T cell potency assay with 3D cancer spheroid models Open
Background The tumor microenvironment poses a significant challenge to immune therapies, like CAR T cells, for solid tumor indications. Development of in vitro 3D models may provide a more accurate assessment of CAR T potency. Here, we dev…
View article: International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment Open
To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 …
View article: Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study Open
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, …
View article: Thalamic state control of cortical paired-pulse dynamics
Thalamic state control of cortical paired-pulse dynamics Open
Sensory stimulation drives complex interactions across neural circuits as information is encoded and then transmitted from one brain region to the next. In the highly interconnected thalamocortical circuit, these complex interactions elici…
View article: Response reliability observed with voltage-sensitive dye imaging of cortical layer 2/3: the probability of activation hypothesis
Response reliability observed with voltage-sensitive dye imaging of cortical layer 2/3: the probability of activation hypothesis Open
A central assertion in the study of neural processing is that our perception of the environment directly reflects the activity of our sensory neurons. This assertion reinforces the intuition that the strength of a sensory input directly mo…
View article: Electrical and Optical Activation of Mesoscale Neural Circuits with Implications for Coding
Electrical and Optical Activation of Mesoscale Neural Circuits with Implications for Coding Open
Artificial activation of neural circuitry through electrical microstimulation and optogenetic techniques is important for both scientific discovery of circuit function and for engineered approaches to alleviate various disorders of the ner…
View article: Optogenetic feedback control of neural activity
Optogenetic feedback control of neural activity Open
Optogenetic techniques enable precise excitation and inhibition of firing in specified neuronal populations and artifact-free recording of firing activity. Several studies have suggested that optical stimulation provides the precision and …
View article: Author response: Optogenetic feedback control of neural activity
Author response: Optogenetic feedback control of neural activity Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Optogenetic techniques enable precise excitatio…