Daniel Morell‐García
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View article: Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus Open
The prevalence of obstructive sleep apnea ( OSA ) increases during pregnancy and is associated with gestational diabetes mellitus ( GDM ), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of sev…
View article: Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in Spain
Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in Spain Open
Objective: To evaluate the economic impact associated with the use of specific brain biomarkers glial fibrillary acid protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) in adult patients with suspected mild traumatic brain injur…
View article: Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in Spain
Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in Spain Open
Objective: To evaluate the economic impact associated with the use of specific brain biomarkers glial fibrillary acid protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) in adult patients with suspected mild traumatic brain injur…
View article: Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy
Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy Open
Obstructive sleep apnea (OSA) is common during pregnancy and linked to adverse outcomes. While oxidative stress is a proposed pathogenic mechanism, evidence in pregnant populations remains limited. This multicenter, prospective study evalu…
View article: Vitamin D Controversies in the Laboratory Medicine: A Review of Clinical Guidelines and Recommendations.
Vitamin D Controversies in the Laboratory Medicine: A Review of Clinical Guidelines and Recommendations. Open
A narrative review of the main guidelines and recommendations published from 2011 up to date about the status of vitamin D deficiency has been carried out. The objective of this review is to discuss the origin of the controversy about the …
View article: Cardiopulmonary Complications after Pulmonary Embolism in COVID-19
Cardiopulmonary Complications after Pulmonary Embolism in COVID-19 Open
Although pulmonary embolism (PE) is a frequent complication in COVID-19, its consequences remain unknown. We performed pulmonary function tests, echocardiography and computed tomography pulmonary angiography and identified blood biomarkers…
View article: Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood
Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood Open
Obstructive sleep apnea (OSA) is quite prevalent during pregnancy and is associated with adverse perinatal outcomes, but its potential influence on fetal development remains unclear. This study investigated maternal OSA impact on the fetus…
View article: Mild head trauma and biomarkers of acute brain injury
Mild head trauma and biomarkers of acute brain injury Open
View article: Pulmonary thrombosis associated with COVID‐19 pneumonia: Beyond classical pulmonary thromboembolism
Pulmonary thrombosis associated with COVID‐19 pneumonia: Beyond classical pulmonary thromboembolism Open
Background Classical pulmonary thromboembolism (TE) and local pulmonary thrombosis (PT) have been suggested as mechanisms of thrombosis in COVID‐19. However, robust evidence is still lacking because this was mainly based on retrospective s…
View article: Pulmonary Thrombosis in Patients With COVID-19 Pneumonia. Is It Really a True Pulmonary Thromboembolism?
Pulmonary Thrombosis in Patients With COVID-19 Pneumonia. Is It Really a True Pulmonary Thromboembolism? Open
Background Mechanisms of pulmonary thrombosis (PT) in COVID-19 are unknown. Thromboembolism and local pulmonary inflammation have been suggested as the main factors. However, robust evidence is still lacking because this was mainly based o…
View article: RNA expression in cord blood. Can obstructive sleep apnea (OSA) during pregnancy have any effect on fetal development?
RNA expression in cord blood. Can obstructive sleep apnea (OSA) during pregnancy have any effect on fetal development? Open
OSA is common during pregnancy and is associated with adverse perinatal consequences, but it is not known whether it can also modulate fetal development processes Methods. OSA was identified by polysomnography during pregnancy and defined …
View article: Traumatic brain injury
Traumatic brain injury Open
BACKGROUND-AIMSerum biomarkers of brain damage called glial fibrillary acidic protein (GFAP) and Ubiquitin C-terminal hydrolase L1 (UCH-L1) can predicting the extent of brain damage in traumatic brain injury (TBI).Our objective is to estab…
View article: Clinical Thresholds for Pseudohyperkalemia and Pseudonormokalemia in Patients with Thrombocytosis.
Clinical Thresholds for Pseudohyperkalemia and Pseudonormokalemia in Patients with Thrombocytosis. Open
This study provides a cut-off value for platelet count interfering serum potassium concentrations, and brings to light not only pseudohyperkalemia-related issues, but also the pseudonormokalemia phenomenon, which usually goes unnoticed.
View article: A Prospective Study Evaluating Cumulative Incidence and a Specific Prediction Rule in Pulmonary Embolism in COVID-19
A Prospective Study Evaluating Cumulative Incidence and a Specific Prediction Rule in Pulmonary Embolism in COVID-19 Open
Rationale Abnormal values of hypercoagulability biomarkers, such as D-dimer, have been described in Coronavirus Disease 2019 (COVID-19), which has also been associated with disease severity and in-hospital mortality. COVID-19 patients with…
View article: W097 Usefulness of urine biomarkers for the prediction of in-hospital mortality in the COVID-19 patients
W097 Usefulness of urine biomarkers for the prediction of in-hospital mortality in the COVID-19 patients Open
View article: Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea Open
Background Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with h…
View article: Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy
Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy Open
Background: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it is associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, and low birth weight. Maternal systemic inflammation is proposed …
View article: Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study) Open
View article: Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality Open
The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a …
View article: Haematology, including haemostasis
Haematology, including haemostasis Open
BACKGROUND-AIM-The main objective of our work is to describe the epidemiological, clinical and especially biochemical profiles of monoclonal gammopathies in the Souss-Massa region in southern Morocco over a period of more than 10 years. ME…
View article: Microbiology - Infectious diseases including COVID 19
Microbiology - Infectious diseases including COVID 19 Open
BACKGROUND-AIMPneumonia caused by SARS-CoV-2 (COVID-19) is associated with inflammatory hyper-response and alterations in the coagulation profile.D-dimer elevation is frequent and values above 1 µg/mL have been associated with increased se…
View article: Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)
Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) Open
View article: Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients
Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients Open
View article: Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study
Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study Open
Background Myocardial injury is a common finding in COVID‐19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of CO…
View article: Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)
Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study) Open
Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patient…
View article: Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children Open
Introduction Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to b…
View article: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study
Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study Open
Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-1…
View article: Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: A case series
Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: A case series Open
View article: Prostate cancer screening: guidelines review and laboratory issues
Prostate cancer screening: guidelines review and laboratory issues Open
Background Prostate-specific antigen (PSA) remains as the most used biomarker in the detection of early prostate cancer (PCa). Clinical practice guidelines (CPGs) are produced to facilitate incorporation of evidence into clinical practice.…
View article: Hemolysis Interference Studies: The Particular Case of Sodium Ion.
Hemolysis Interference Studies: The Particular Case of Sodium Ion. Open
Reproducibility of hemolysate preparation is procedure-dependent. A greater standardization is needed for the preparation of a true hemolysate to better quantify the degree of interference of clinically relevant analytes, especially those …