Daniel Mussa
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View article: Activation and proliferation profiles of M.tuberculosis specific dual functional CD4+T cells from smear negative pulmonary TB patients
Activation and proliferation profiles of M.tuberculosis specific dual functional CD4+T cells from smear negative pulmonary TB patients Open
Background Tuberculosis is a major public health challenge in the resource-limited endemic setting of sub-Saharan Africa. The diagnostic challenge becomes worse for smear-negative TB cases. Even if efforts for non-sputum-based TB diagnosti…
View article: The role of IgA and IgG in <i>Mycobacterium tuberculosis</i> infection: A cross-sectional study in Ethiopia
The role of IgA and IgG in <i>Mycobacterium tuberculosis</i> infection: A cross-sectional study in Ethiopia Open
Introduction Despite the high global prevalence of Mycobacterium tuberculosis (Mtb) infection in humans, most infected individuals achieve a stable immunological equilibrium, without showing clinical signs and symptoms of tuberculosis (TB)…
View article: Persistent expression of activation markers on Mycobacterium tuberculosis-specific CD4 T cells in smear negative TB patients
Persistent expression of activation markers on Mycobacterium tuberculosis-specific CD4 T cells in smear negative TB patients Open
Background T cell activation (HLA-DR, CD-38), proliferation (KI-67), and functional (IFN-γ, TNF-α) markers have recently been shown to be useful in predicting and monitoring anti-TB responses in smear positive TB, but previous research did…
View article: The Impact of Diabetes and Prediabetes on Prevalence of <i>Mycobacterium tuberculosis</i> Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia
The Impact of Diabetes and Prediabetes on Prevalence of <i>Mycobacterium tuberculosis</i> Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia Open
Background It is uncertain whether diabetes affects the risk of developing latent tuberculosis infection (LTBI) following exposure to Mycobacterium tuberculosis (Mtb). We assessed the relationship of diabetes or prediabetes and LTBI among …
View article: <i>Mycobacterium tuberculosis</i>antigen-specific T-cell responses in smear-negative pulmonary tuberculosis patients
<i>Mycobacterium tuberculosis</i>antigen-specific T-cell responses in smear-negative pulmonary tuberculosis patients Open
Despite recent improvements in microbial detection, smear-negative TB remains a diagnostic challenge. In this study, we investigated the potential discriminatory role of polychromatic flow cytometry of M. tuberculosis antigen-specific T ce…