Daniel N. Darlington
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View article: Trauma and Hemorrhage Lead to an Elevation in Fecal Short-Chain Fatty Acids
Trauma and Hemorrhage Lead to an Elevation in Fecal Short-Chain Fatty Acids Open
Introduction Severe trauma and hemorrhage in rats lead to changes in the beta diversity of the commensal bacteria found in the gut. Because Short-Chain Fatty Acids (SCFA) are produced by these bacteria, SCFA concentration may also change f…
View article: Conjugation of Short-Chain Fatty Acids to Bicyclic-Amines for Analysis by Liquid Chromatography Tandem Mass Spectroscopy
Conjugation of Short-Chain Fatty Acids to Bicyclic-Amines for Analysis by Liquid Chromatography Tandem Mass Spectroscopy Open
Conjugation of short-chain fatty acids (SDFAs) to amines containing ring structures allows for better measurement by liquid chromatography tandem mass spectroscopy (LC-MS/MS). However, collision-induced dissociation (CID) results in breaki…
View article: Prolyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock
Prolyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock Open
View article: Prolyl hydroxylase domain inhibitor: a potential pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock
Prolyl hydroxylase domain inhibitor: a potential pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock Open
Trauma and hemorrhagic shock-associated pre-hospital deaths are mainly due to hypoperfusion-induced tissue hypoxia leading to irreversible organ dysfunction at or near the point of injury or during transportation prior to receiving definit…
View article: A novel, quantitative clot retraction assay to evaluate platelet function
A novel, quantitative clot retraction assay to evaluate platelet function Open
Blood platelets are crucial to prevent excessive bleeding following injury to blood vessels. Platelets are crucial for the formation of clots and for clot strength. Platelet activation involves aggregation, attachment to fibrin and clot re…
View article: Metabolic effects of radiation on red blood cells from cold stored whole blood
Metabolic effects of radiation on red blood cells from cold stored whole blood Open
Background The risk of military and civilian radiation exposure is increasing, and determining the effects of exposure is a high priority. Irradiation of the nearby blood supply after a nuclear event may impede mobilization of blood produc…
View article: Syndecan-1 and thrombomodulin are early biomarkers for development of endotheliopathy in trauma and hemorrhagic shock
Syndecan-1 and thrombomodulin are early biomarkers for development of endotheliopathy in trauma and hemorrhagic shock Open
The causes of endotheliopathy are multifactorial and trauma dependent, and the temporal mechanistic link that it has with acute traumatic coagulopathy (ATC) has yet to be fully determined. Therefore, we sought to define early characteristi…
View article: Effects of radiation exposure and storage on the energy metabolome of platelets in whole blood
Effects of radiation exposure and storage on the energy metabolome of platelets in whole blood Open
Background Exposure to radiation through battlefield use of nuclear weapons, terrorist attacks or accidents at nuclear power plants is a current concern for the military. Beyond the risk of exposure to personnel is the intentional or accid…
View article: A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature
A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature Open
Implantable loop recorders (ILR) are devices that are implanted subcutaneously on the chest, which enables the continuous monitoring of arrhythmias for up to three years. These devices have an important role in helping to make a diagnosis …
View article: Efficacy and safety of leadless pacemaker: A systematic review, pooled analysis and meta-analysis
Efficacy and safety of leadless pacemaker: A systematic review, pooled analysis and meta-analysis Open
View article: Outcomes of Patients Who Have Incidental Non-Sustained Ventricular Tachycardia Identified on Cardiac Implantable Electronic Device Interrogation
Outcomes of Patients Who Have Incidental Non-Sustained Ventricular Tachycardia Identified on Cardiac Implantable Electronic Device Interrogation Open
Background: Non-sustained ventricular tachycardia (NSVT) is an arrhythmia prevalent in both structurally normal and abnormal hearts. Methods: We conducted a single-center retrospective clinical audit of patients followed-up in a device cli…
View article: Clinical features and outcomes of adults with coronavirus disease 2019: A systematic review and pooled analysis of the literature
Clinical features and outcomes of adults with coronavirus disease 2019: A systematic review and pooled analysis of the literature Open
COVID-19 most commonly presents with fever, cough, fatigue and anorexia and among patients with existing hypertension and cardiovascular disease. It is important as serious adverse outcomes can develop such as acute respiratory distress sy…
View article: Use of Specialized Pro‐Resolving Mediators to Alleviate Cold Platelet Storage Lesion
Use of Specialized Pro‐Resolving Mediators to Alleviate Cold Platelet Storage Lesion Open
BACKGROUND Cold‐stored platelets are an attractive option for treatment of actively bleeding patients due to a reduced risk of septic complications and preserved hemostatic function compared to conventional room temperature–stored platelet…
View article: Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage
Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage Open
Trauma and hemorrhagic shock can lead to acute traumatic coagulopathy (ATC) that is not fully reversed by prehospital resuscitation as simulated with a limited volume of fresh whole blood (FWB) in a rat model. Tranexamic Acid (TXA) is used…
View article: Platelets derived from fresh and cold‐stored whole blood participate in clot formation in rats with acute traumatic coagulopathy
Platelets derived from fresh and cold‐stored whole blood participate in clot formation in rats with acute traumatic coagulopathy Open
Summary The in vitro haemostatic functions of fresh whole blood ( FWB ) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood ( SWB ) contribute to clot formation in …
View article: Proceedings of the 5th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2017
Proceedings of the 5th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2017 Open
View article: Proceedings of the 4th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2016
Proceedings of the 4th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2016 Open
View article: Procoagulant and fibrinolytic activity after polytrauma in rat
Procoagulant and fibrinolytic activity after polytrauma in rat Open
The purpose of this study was to determine whether trauma-induced coagulopathy is due to changes in 1) thrombin activity, 2) plasmin activity, and/or 3) factors that stimulate or inhibit thrombin or plasmin. Sprague-Dawley rats were anesth…