Daniel Nissman
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View article: Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative
Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative Open
OBJECTIVES: To identify trajectories of joint space width loss, a proxy measure of tibiofemoral cartilage loss, among previously injured knees. To describe the relationship of trajectory groups with sociodemographic and clinical risk facto…
View article: Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative
Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative Open
Objectives To identify trajectories of joint space width loss, a proxy measure of tibiofemoral cartilage loss, among previously injured knees. To describe the relationship of trajectory groups with sociodemographic and clinical risk factor…
View article: Investigating the relationship between radiographic joint space width loss and deep learning-derived magnetic resonance imaging-based cartilage thickness loss in the medial weight-bearing region of the tibiofemoral joint
Investigating the relationship between radiographic joint space width loss and deep learning-derived magnetic resonance imaging-based cartilage thickness loss in the medial weight-bearing region of the tibiofemoral joint Open
Despite its recommended use in disease-modifying OA drug clinical trials, results suggest that JSW loss is an ineffective proxy measure of cartilage thickness loss over 12-24 months and within a localized region of the tibiofemoral joint.
View article: Sustained <scp>Limb‐Level</scp> Loading: A Ground Reaction Force Phenotype Common to Individuals at High Risk for and Those With Knee Osteoarthritis
Sustained <span>Limb‐Level</span> Loading: A Ground Reaction Force Phenotype Common to Individuals at High Risk for and Those With Knee Osteoarthritis Open
Objective The objective of this study was to compare the vertical (vGRF), anterior‐posterior (apGRF), and medial‐lateral (mlGRF) ground reaction force (GRF) profiles throughout the stance phase of gait (1) between individuals 6 to 12 month…
View article: Charting Aging Trajectories of Knee Cartilage Thickness for Early Osteoarthritis Risk Prediction: An MRI Study from the Osteoarthritis Initiative Cohort
Charting Aging Trajectories of Knee Cartilage Thickness for Early Osteoarthritis Risk Prediction: An MRI Study from the Osteoarthritis Initiative Cohort Open
Knee osteoarthritis (OA), a prevalent joint disease in the U.S., poses challenges in terms of predicting of its early progression. Although high-resolution knee magnetic resonance imaging (MRI) facilitates more precise OA diagnosis, the he…
View article: Point-of-Care Tomosynthesis Imaging of the Wrist
Point-of-Care Tomosynthesis Imaging of the Wrist Open
Introduction: Musculoskeletal injury to extremities is a common issue for both stateside and deployed military personnel, as well as the general public. Superposition of anatomy can make diagnosis difficult using standard clinical techniqu…
View article: Gait Variability Structure Linked to Worse Cartilage Composition Post-ACL Reconstruction
Gait Variability Structure Linked to Worse Cartilage Composition Post-ACL Reconstruction Open
Introduction Aberrant gait variability has been observed after anterior cruciate ligament reconstruction (ACLR), yet it remains unknown if gait variability is associated with early changes in cartilage composition linked to osteoarthritis …
View article: Patterns of variation among baseline femoral and tibial cartilage thickness and clinical features: Data from the osteoarthritis initiative
Patterns of variation among baseline femoral and tibial cartilage thickness and clinical features: Data from the osteoarthritis initiative Open
This exploratory analysis, combining the rich OAI dataset with novel methods for determining and visualizing cartilage thickness, reinforces known associations in knee OA while providing insights into the potential for data integration in …
View article: Worse Tibiofemoral Cartilage Composition Is Associated with Insufficient Gait Kinetics After ACL Reconstruction
Worse Tibiofemoral Cartilage Composition Is Associated with Insufficient Gait Kinetics After ACL Reconstruction Open
Purpose Greater articular cartilage T1ρ magnetic resonance imaging relaxation times indicate less proteoglycan density and are linked to posttraumatic osteoarthritis development after anterior cruciate ligament reconstruction (ACLR). Altho…
View article: Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty Open
Sarcopenia, defined as the loss of muscle mass, strength, and function with aging, is a geriatric syndrome with important implications for patients and healthcare systems. Sarcopenia increases the risk of clinical decompensation when faced…
View article: Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty Open
Sarcopenia, defined as the loss of muscle mass, strength, and function with aging, is a geriatric syndrome with important implications for patients and healthcare systems. Sarcopenia increases the risk of clinical decompensation when faced…
View article: Loading during Midstance of Gait Is Associated with Magnetic Resonance Imaging of Cartilage Composition Following Anterior Cruciate Ligament Reconstruction
Loading during Midstance of Gait Is Associated with Magnetic Resonance Imaging of Cartilage Composition Following Anterior Cruciate Ligament Reconstruction Open
Objective A complex association exists between aberrant gait biomechanics and posttraumatic knee osteoarthritis (PTOA) development. Previous research has primarily focused on the link between peak loading during the loading phase of stance…
View article: Bone bruising severity after anterior cruciate ligament rupture predicts elevation of chemokine MCP‐1 associated with osteoarthritis
Bone bruising severity after anterior cruciate ligament rupture predicts elevation of chemokine MCP‐1 associated with osteoarthritis Open
Purpose Anterior cruciate ligament rupture is associated with characteristic bone contusions in approximately 80% of patients, and these have been correlated with higher pain scores. Bone bruising may indicate joint damage that increases i…
View article: Association of Jump-Landing Biomechanics With Tibiofemoral Articular Cartilage Composition 12 Months After ACL Reconstruction
Association of Jump-Landing Biomechanics With Tibiofemoral Articular Cartilage Composition 12 Months After ACL Reconstruction Open
Background: Excessively high joint loading during dynamic movements may negatively influence articular cartilage health and contribute to the development of posttraumatic osteoarthritis after anterior cruciate ligament reconstruction (ACLR…
View article: Changes in Infrapatellar Fat Pad Volume 6 to 12 Months After Anterior Cruciate Ligament Reconstruction and Associations With Patient-Reported Knee Function
Changes in Infrapatellar Fat Pad Volume 6 to 12 Months After Anterior Cruciate Ligament Reconstruction and Associations With Patient-Reported Knee Function Open
Context Hypertrophy of the infrapatellar fat pad (IFP) in idiopathic knee osteoarthritis has been linked to deleterious synovial changes and joint pain related to mechanical tissue impingement. Yet little is known regarding the IFP's volum…
View article: Talar and Subtalar T1ρ Relaxation Times in Limbs with and without Chronic Ankle Instability
Talar and Subtalar T1ρ Relaxation Times in Limbs with and without Chronic Ankle Instability Open
Objective The primary aim was to determine differences in talocrural and subtalar joint (STJ) articular cartilage composition, using T1ρ magnetic resonance imaging (MRI) relaxation times, between limbs in individuals with unilateral chroni…
View article: In Vivo Compositional Changes in the Articular Cartilage of the Patellofemoral Joint Following Anterior Cruciate Ligament Reconstruction
In Vivo Compositional Changes in the Articular Cartilage of the Patellofemoral Joint Following Anterior Cruciate Ligament Reconstruction Open
Objective To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral extremity. Greater …
View article: Point-of-Care Tomosynthesis Imaging of the Wrist
Point-of-Care Tomosynthesis Imaging of the Wrist Open
Introduction Musculoskeletal injury to extremities is a common issue for both stateside and deployed military personnel, as well as the general public. Superposition of anatomy can make diagnosis difficult using standard clinical technique…
View article: Subgroup Variation in Diagnostic Tests: Sources and Solutions
Subgroup Variation in Diagnostic Tests: Sources and Solutions Open
Diagnostic tests are an essential component of clinical medicine today. Like any other clinical study, the results of studies evaluating new diagnostic tests must be interpreted in the context of underlying methodological problems and gene…
View article: Ultrasonographic Assessment of Femoral Cartilage in Individuals With Anterior Cruciate Ligament Reconstruction: A Case-Control Study
Ultrasonographic Assessment of Femoral Cartilage in Individuals With Anterior Cruciate Ligament Reconstruction: A Case-Control Study Open
Context Developing osteoarthritis is common after anterior cruciate ligament reconstruction (ACLR). Monitoring changes in femoral cartilage size after ACLR may be a way to detect the earliest structural alterations before the radiographic …
View article: Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction
Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction Open
Objective To determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction ( ACLR ), is associated with inter‐extremity differences in proteoglycan density, measured via T1ρ magnetic reso…