Daniel Thomas‐Rüddel
YOU?
Author Swipe
View article: Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data
Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data Open
Purpose Sepsis is a leading cause of morbidity and mortality, yet its documentation and coding in administrative health data remain unreliable. Accurate coding is essential for epidemiological surveillance, quality assurance, and reimburse…
View article: Effect of body mass index on postoperative recovery to independent living: a retrospective cohort study*
Effect of body mass index on postoperative recovery to independent living: a retrospective cohort study* Open
Summary Introduction Living with obesity is a risk factor for diabetes, cardiovascular disease and cancer. The ‘obesity paradox’ suggests patients who are overweight or living with mild obesity experience better outcomes after surgery and …
View article: Blood biomarker and Raman analysis of leukocytes in the multicenter INTELLIGENCE trials: at the Intensive Care Unit (INTELLIGENCE-1) and the Emergency Department (INTELLIGENCE-2)
Blood biomarker and Raman analysis of leukocytes in the multicenter INTELLIGENCE trials: at the Intensive Care Unit (INTELLIGENCE-1) and the Emergency Department (INTELLIGENCE-2) Open
Background: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, goes along with a complex and not yet fully understood host response. Despite many different biomarkers, optimal screeni…
View article: IFNγ in human sepsis: a scoping review
IFNγ in human sepsis: a scoping review Open
Background The cytokine IFNγ is released primarily by lymphocytes to initiate and orchestrate immune responses in a broad range of target cells. Whereas immune cells release inflammatory mediators and initiate antimicrobial responses when …
View article: Barriers and facilitators to optimal sepsis care – a systematized review of healthcare professionals’ perspectives
Barriers and facilitators to optimal sepsis care – a systematized review of healthcare professionals’ perspectives Open
Background Despite therapeutic advances, sepsis remains a global burden. Shortcomings within the healthcare system that inflate morbidity and mortality rates are instructive in this regard. This review aims to provide a qualitative synthes…
View article: Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients
Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients Open
Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid treatment.
View article: Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial
Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial Open
Introduction Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of seps…
View article: Perceptions of Quality of Interprofessional Collaboration, Staff Well-Being and Nonbeneficial Treatment: A Comparison between Nurses and Physicians in Intensive and Palliative Care
Perceptions of Quality of Interprofessional Collaboration, Staff Well-Being and Nonbeneficial Treatment: A Comparison between Nurses and Physicians in Intensive and Palliative Care Open
This study assessed differences in interprofessional collaboration, perception of nonbeneficial care, and staff well-being between critical care and palliative care teams. In six German hospitals, a staff survey was conducted between Decem…
View article: (1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial
(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial Open
Serum BDG guided antifungal treatment did not improve 28-day mortality among sepsis patients with risk factors for but unexpected low rate of IC. This study cannot comment on the potential benefit of BDG-guidance in a more selected at-risk…
View article: The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Controlled Interrupted Time Series Analysis
The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Controlled Interrupted Time Series Analysis Open
Background Sepsis is one of the leading causes of preventable deaths in hospitals. This study presents the evaluation of a quality collaborative, which aimed to decrease sepsis-related hospital mortality. Methods The German Quality Network…
View article: Reviews of "COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase"
Reviews of "COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase" Open
Reviewers: Johnny Stiban (Birzeit University) | ðððâ»ï¸â»ï¸ ⢠Ralf A. Claus, Daniel Thomas-Rüddel (Jena University Hospital) | ððððâ»ï¸ ⢠Undurti Das (UND Life Sciences)ðððâ»ï¸â»ï¸
View article: Review 2: "COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase"
Review 2: "COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase" Open
Review 2: "COVID-19 and its clinical severity are associated with alterations of plasma
View article: Towards an ecological definition of sepsis: a viewpoint
Towards an ecological definition of sepsis: a viewpoint Open
In critically ill patients with sepsis, there is a grave lack of effective treatment options to address the illness-defining inappropriate host response. Currently, treatment is limited to source control and supportive care, albeit with im…
View article: The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Quasi-Experimental Difference-in-Differences Design
The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Quasi-Experimental Difference-in-Differences Design Open
BackgroundSepsis is one of the leading causes of preventable deaths in hospitals. This study presents the evaluation of a quality collaborative network, which aimed to decrease sepsis-related hospital mortality.MethodsThe German Quality Ne…
View article: Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature
Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature Open
Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary …
View article: Risk Factors for Invasive Candida Infection in Critically Ill Patients
Risk Factors for Invasive Candida Infection in Critically Ill Patients Open
Our systematic review and meta-analysis identified patient- and treatment-related factors that were associated with the risk for the development of invasive Candida infection in the ICU. Most of the factors identified were either related t…
View article: Biochemical Analysis of Leukocytes after In Vitro and In Vivo Activation with Bacterial and Fungal Pathogens Using Raman Spectroscopy
Biochemical Analysis of Leukocytes after In Vitro and In Vivo Activation with Bacterial and Fungal Pathogens Using Raman Spectroscopy Open
Biochemical information from activated leukocytes provide valuable diagnostic information. In this study, Raman spectroscopy was applied as a label-free analytical technique to characterize the activation pattern of leukocyte subpopulation…
View article: Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis
Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis Open
Objectives: Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis. This study aims to use the Raman spectroscopic fingerprints o…
View article: Ex Vivo Immune Profiling in Patient Blood Enables Quantification of Innate Immune Effector Functions
Ex Vivo Immune Profiling in Patient Blood Enables Quantification of Innate Immune Effector Functions Open
Assessment of a patient’s immune function is critical in many clinical situations. One prominent example is sepsis, which results from a loss of immune homeostasis due to microbial infection and is characterized by a plethora of pro- and a…
View article: <i>Ex vivo</i>Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions
<i>Ex vivo</i>Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions Open
The immune response towards infection is a dynamic system combating invading pathogens to maintain homeostasis and the integrity of the body. Unbalanced immune response profiles determine many clinical syndromes including sepsis and thus p…