Daniel Ojeda-Juárez
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View article: PrP<sup>C</sup>-induced signaling in human neurons activates phospholipase Cɣ1 and an Arc/Arg3.1 response
PrP<sup>C</sup>-induced signaling in human neurons activates phospholipase Cɣ1 and an Arc/Arg3.1 response Open
Synaptic dysfunction and loss correlate with cognitive decline in neurodegenerative diseases, including Alzheimer’s disease (AD) and prion disease. Neuronal hyperexcitability occurs in the early stages of AD and experimental prion disease,…
View article: Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice
Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice Open
Neuronal hyperexcitability precedes synapse loss in certain neurodegenerative diseases, yet the synaptic membrane interactions and downstream signaling events remain unclear. The disordered amino terminus of the prion protein (PrPC) has be…
View article: Chronic, Low-Dose Methamphetamine Reveals Sexual Dimorphism of Memory Performance, Histopathology, and Gene Expression Affected by HIV-1 Tat Protein in a Transgenic Model of NeuroHIV
Chronic, Low-Dose Methamphetamine Reveals Sexual Dimorphism of Memory Performance, Histopathology, and Gene Expression Affected by HIV-1 Tat Protein in a Transgenic Model of NeuroHIV Open
Methamphetamine (METH) use is frequent among people with HIV (PWH) and appears to increase the risk of neuronal injury and neurocognitive impairment (NCI). This study explored in vivo the effects of a 12 week (long-term), low-dose METH reg…
View article: A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury
A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury Open
Macrophages (MΦ) infected with human immunodeficiency virus (HIV)-1 or activated by its envelope protein gp120 exert neurotoxicity. We found previously that signaling via p38 mitogen-activated protein kinase (p38 MAPK) is essential to the …
View article: TREATMENT WITH LOW DOSE METHAMPHETAMINE MODULATES GENES ASSOCIATED WITH AGING, POTENTIALLY COUNTERACTING PATHWAYS CONTRIBUTING TO AD/HAND
TREATMENT WITH LOW DOSE METHAMPHETAMINE MODULATES GENES ASSOCIATED WITH AGING, POTENTIALLY COUNTERACTING PATHWAYS CONTRIBUTING TO AD/HAND Open
View article: Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration
Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration Open
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or…
View article: Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus Open
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrPC),
View article: Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders
Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders Open
Early in the HIV pandemic, it became evident that people living with HIV (PLWH) develop a wide range of neurological and neurocognitive complications. Even after the introduction of combination antiretroviral therapy (cART), which dramatic…
View article: Comprehensive review of lipocalin 2-mediated effects in lung inflammation
Comprehensive review of lipocalin 2-mediated effects in lung inflammation Open
Lipocalin-2 (LCN2) is an inflammatory mediator best known for its role as an innate acute-phase protein. LCN2 mediates the innate immune response to pathogens by sequestering iron, thereby inhibiting pathogen growth. Although LCN2 and its …
View article: The Role of Lipocalin-2 (LCN2) in Organic Dust-Induced Lung Inflammation
The Role of Lipocalin-2 (LCN2) in Organic Dust-Induced Lung Inflammation Open
View article: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1 Open
Background HIV-1 infection remains a major public health concern despite effective combination antiretroviral therapy (cART). The virus enters the central nervous system (CNS) early in infection and continues to cause HIV-associated neuroc…
View article: Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection
Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection Open
View article: CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK Open
Our findings link CXCL12-induced neuronal death to the regulation of NMDAR-gated ion channels and L-type Ca2+ channels upstream of p38 MAPK activation.