Daniel González
YOU?
Author Swipe
View article: Evidence for Aerosolized Environmental Bacterial Endotoxin as an Environmental Health Hazard
Evidence for Aerosolized Environmental Bacterial Endotoxin as an Environmental Health Hazard Open
The high incidence of asthma near California’s Salton Sea is attributed to dust emitted from the exposed lakebed. A survey of clinical symptoms conducted in the region revealed distinct spatial distribution with strong geospatial correlati…
View article: P-580 Impact of third pronucleus size as a predictive marker for genetic outcomes in 349 zygotes with three pronuclei (3PN)
P-580 Impact of third pronucleus size as a predictive marker for genetic outcomes in 349 zygotes with three pronuclei (3PN) Open
Study question Is there a correlation between the size of the third pronucleus in embryos derived from zygotes with three pronuclei (3PN) and their genetic outcome? Summary answer The size of the third pronucleus in embryos derived from zy…
View article: Leveraging <i>In Silico</i> and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan
Leveraging <i>In Silico</i> and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan Open
Incorporating inter‐individual differences in drug disposition and responses is essential for ensuring the safe and effective use of drugs in real‐world patients. Despite ongoing efforts, lower participation of children, older individuals,…
View article: P-1222. Oral Cephalexin Population Pharmacokinetics and Target Attainment Analysis in Infants 0-60 Days Old
P-1222. Oral Cephalexin Population Pharmacokinetics and Target Attainment Analysis in Infants 0-60 Days Old Open
Background Transitioning from intravenous (IV) to oral (PO) antibiotics is uncommon practice in young infants due to a lack of pharmacokinetic (PK) or pharmacodynamic (PD) data to guide effective PO doses. Cephalexin is a promising PO trea…
View article: Pharmacokinetics, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants with Developing Bronchopulmonary Dysplasia (Prism)
Pharmacokinetics, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants with Developing Bronchopulmonary Dysplasia (Prism) Open
View article: Evaluation of Hemoglobin and Serum Erythropoietin Levels in Patients with Polycythemia Vera and Secondary polycythemia
Evaluation of Hemoglobin and Serum Erythropoietin Levels in Patients with Polycythemia Vera and Secondary polycythemia Open
Objective: This study compares and evaluates hemoglobin and erythropoietin levels in patients with polycythemia vera and secondary polycythemia. Design: This was aretrospective cross-sectional study evaluating the serum erythropoietin and …
View article: Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of <scp>CYP2C19</scp> genetic variation and obesity in the pediatric population
Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of <span>CYP2C19</span> genetic variation and obesity in the pediatric population Open
Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires …
View article: Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19
Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19 Open
Importance The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown. Objective To characterize abatacept pharmacokinetics, relate drug exposure with clinical…
View article: Sources of pharmacokinetic and pharmacodynamic variability and clinical pharmacology studies of antiseizure medications in the pediatric population
Sources of pharmacokinetic and pharmacodynamic variability and clinical pharmacology studies of antiseizure medications in the pediatric population Open
Multiple treatment options exist for children with epilepsy, including surgery, dietary therapies, neurostimulation, and antiseizure medications (ASMs). ASMs are the first line of therapy, and more than 30 ASMs have U.S. Food and Drug Admi…
View article: Indomethacin Pharmacokinetics and Pharmacodynamics in Pregnancies With Preterm Labor: The Need for Dose‐Ranging Trials
Indomethacin Pharmacokinetics and Pharmacodynamics in Pregnancies With Preterm Labor: The Need for Dose‐Ranging Trials Open
The use of indomethacin to delay delivery in preterm labor (PTL) is widely accepted; however, the optimal dosage of indomethacin in pregnancy is unknown. Here, we perform population pharmacokinetic (PK) and pharmacodynamic (PD) analyses, c…
View article: PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF PIOGLITAZONE: EVALUATING THE EFFECT OF THE CYTOCHROME P450 2C8*2 SINGLE NUCLEOTIDE POLYMORPHISM
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF PIOGLITAZONE: EVALUATING THE EFFECT OF THE CYTOCHROME P450 2C8*2 SINGLE NUCLEOTIDE POLYMORPHISM Open
View article: Evaluation of Hemoglobin and Serum Erythropoietin Levels in Patients with Polycythemia Vera and Secondary Polycythemia
Evaluation of Hemoglobin and Serum Erythropoietin Levels in Patients with Polycythemia Vera and Secondary Polycythemia Open
Objective: This study compares hemoglobin and erythropoietin levels in patients with polycythemia vera and secondary polycythemia. Study Design: A retrospective cross-sectional study evaluating the serum erythropoietin and hemoglobin level…
View article: Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment
Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment Open
A population PK model of vancomycin was developed using data obtained from adult Sudanese patients. Model-based dose optimization can aid clinicians in selecting initial vancomycin doses that will maximize the likelihood of a favorable tre…
View article: Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury
Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury Open
Cardiac surgery‐associated acute kidney injury (CS‐AKI) occurs in approximately 65% of neonates undergoing cardiac surgery on cardiopulmonary bypass and contributes to morbidity and mortality. Caffeine may reduce CS‐AKI by counteracting ad…
View article: EVIDENCE OF LONG-TERM ALLOCENTRIC SPATIAL MEMORY IN THE TERRESTRIAL HERMIT CRAB COENOBITA COMPRESSUS
EVIDENCE OF LONG-TERM ALLOCENTRIC SPATIAL MEMORY IN THE TERRESTRIAL HERMIT CRAB COENOBITA COMPRESSUS Open
View article: Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia
Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia Open
Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia. Design, Setting, and P…
View article: V-004 ROBOTIC PARASTOMAL HERNIA REPAIR WITH RETROMUSCULAR MESH (PAULI TECHNIQUE)
V-004 ROBOTIC PARASTOMAL HERNIA REPAIR WITH RETROMUSCULAR MESH (PAULI TECHNIQUE) Open
Aim Parastomal hernia is a common complication of ostomy formation. We present a case of robotic parastomal hernia repair with retromuscular mesh (Pauli technique). Material and Methods Patient was 58 years-old man and had history of anter…
View article: Effects of obesity on the pharmacology of proton pump inhibitors: current understanding and future implications for patient care and research
Effects of obesity on the pharmacology of proton pump inhibitors: current understanding and future implications for patient care and research Open
Published PK data in adults and children are limited to first-generation PPIs and point toward reduced apparent oral drug clearance in obesity, with equipoise regarding obesity impact on drug absorption. Available PD data are sparse, confl…
View article: A phase I trial of caffeine to evaluate safety in infants with hypoxic-ischemic encephalopathy
A phase I trial of caffeine to evaluate safety in infants with hypoxic-ischemic encephalopathy Open
View article: 2022-RA-1593-ESGO Isolated para-aortic lymph node metastases in high risk endometrial cancer
2022-RA-1593-ESGO Isolated para-aortic lymph node metastases in high risk endometrial cancer Open
View article: Abatacept for Treatment of Adults Hospitalized with Moderate or Severe Covid-19
Abatacept for Treatment of Adults Hospitalized with Moderate or Severe Covid-19 Open
Background We investigated whether abatacept, a selective costimulation modulator, provides additional benefit when added to standard-of-care for patients hospitalized with Covid-19. Methods We conducted a master protocol to investigate im…
View article: Infliximab for Treatment of Adults Hospitalized with Moderate or Severe Covid-19
Infliximab for Treatment of Adults Hospitalized with Moderate or Severe Covid-19 Open
Background Immune dysregulation contributes to poorer outcomes in severe Covid-19. Immunomodulators targeting various pathways have improved outcomes. We investigated whether infliximab provides benefit over standard of care. Methods We co…
View article: Extrapolation of Adult Efficacy Data to Pediatric Systemic Lupus Erythematosus: Evaluating Similarities in Exposure–Response
Extrapolation of Adult Efficacy Data to Pediatric Systemic Lupus Erythematosus: Evaluating Similarities in Exposure–Response Open
To streamline drug development, the United States Food and Drug Administration (FDA) can consider the extrapolation of adult efficacy data to children when the disease and drug effects are sufficiently similar. This study explored whether …
View article: Seed morphology data for Orchis canariensis and Orchis patens
Seed morphology data for Orchis canariensis and Orchis patens Open
Dataset of seed mesures for Orchis canariensis and Orchis patens used in the publication: "SEED MICROMORPHOLOGY SUPPORTS SPECIES DELIMITATION OF ORCHIS CANARIENSIS (ORCHIDACEAE), AN ENDEMIC ORCHID FROM CANARY ISLA…
View article: Seed morphology data for Orchis canariensis and Orchis patens
Seed morphology data for Orchis canariensis and Orchis patens Open
Dataset of seed mesures for Orchis canariensis and Orchis patens used in the publication: "SEED MICROMORPHOLOGY SUPPORTS SPECIES DELIMITATION OF ORCHIS CANARIENSIS (ORCHIDACEAE), AN ENDEMIC ORCHID FROM CANARY ISLA…
View article: Machine learning‐guided covariate selection for time‐to‐event models developed from a small sample of real‐world patients receiving bevacizumab treatment
Machine learning‐guided covariate selection for time‐to‐event models developed from a small sample of real‐world patients receiving bevacizumab treatment Open
Therapeutic outcomes in patients with metastatic colorectal cancer (mCRC) receiving bevacizumab treatment are highly variable, and a reliable predictive factor is not available. Progression‐free survival (PFS) and overall survival (OS) wer…
View article: Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real‐World Patients
Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real‐World Patients Open
Population pharmacokinetic (PK)/pharmacodynamic models are commonly used to inform drug dosing; however, often real‐world patients are not well represented in the clinical trial population. We sought to determine how well dosing recommende…
View article: Use of Real‐World Data and Physiologically‐Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children With Obesity
Use of Real‐World Data and Physiologically‐Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children With Obesity Open
Dosing guidance for children with obesity is often unknown despite the fact that nearly 20% of US children are classified as obese. Enoxaparin, a commonly prescribed low‐molecular‐weight heparin, is dosed based on body weight irrespective …
View article: Improving the Performance of Closet-Set Classification in Human Activity Recognition by Applying a Residual Neural Network Architecture
Improving the Performance of Closet-Set Classification in Human Activity Recognition by Applying a Residual Neural Network Architecture Open
The Time Series Classification Residual Network (TSCResNet) deep learning model is introduced in this study to improve the classification performance in the human activity recognition (HAR) problem. Specifically in the context of closed-se…
View article: Inicio de la vía oral en el período posoperatorio de la cirugía gastrointestinal: preferencias del paciente
Inicio de la vía oral en el período posoperatorio de la cirugía gastrointestinal: preferencias del paciente Open
Introducción: el inicio temprano de la vía oral en el período posoperatorio de la cirugía gastrointestinal ha demostrado ser factible y benéfico; sin embargo, los pacientes siguen teniendo ayunos prolongados. El objetivo de este estudio fu…