Joshua D. Ooi
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View article: The Potential of β-Synuclein-Specific Regulatory T Cell Therapy as a Treatment for Progressive Multiple Sclerosis
The Potential of β-Synuclein-Specific Regulatory T Cell Therapy as a Treatment for Progressive Multiple Sclerosis Open
Disease progression in multiple sclerosis (MS) is now known to affect many patients, even those not diagnosed with progressive subtypes. Progressive and neurodegenerative aspects of MS are poorly treated by currently available therapies. R…
View article: Regulatory T cell therapy for myeloperoxidase-specific anti-neutrophil cytoplasmic antibody associated vasculitis
Regulatory T cell therapy for myeloperoxidase-specific anti-neutrophil cytoplasmic antibody associated vasculitis Open
Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by the inflammation of small vessels. It is most commonly caused by ANCA targeting proteinase 3 (PR3) and myeloperoxidase …
View article: Low dose IL-2 administration prevents but fails to treat experimental autoimmune anti-myeloperoxidase glomerulonephritis
Low dose IL-2 administration prevents but fails to treat experimental autoimmune anti-myeloperoxidase glomerulonephritis Open
Background and hypothesis Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a major cause of glomerulonephritis (GN) and kidney failure and current therapies are often limited by significant toxicity and limitation…
View article: Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis
Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis Open
Introduction This study investigates the therapeutic potential of blocking key CD4 + Th1 effector cytokines, TNF-α and IFN-γ, in experimental anti-myeloperoxidase (MPO) glomerulonephritis (GN). The immunopathogenesis of MPO autoimmunity is…
View article: SAPrIm 2.0: a semi-automated protocol for mid-throughput soluble HLA immunopeptidomics
SAPrIm 2.0: a semi-automated protocol for mid-throughput soluble HLA immunopeptidomics Open
Human leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process is central to the development of cancer i…
View article: Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti–glomerular basement membrane disease antigen
Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti–glomerular basement membrane disease antigen Open
Anti-glomerular basement membrane (anti-GBM) disease is accompanied by insufficient antigen-specific regulatory T cells (Tregs) and clonally expanded antigen-specific conventional T cells. In particular, this applied to the immunodominant …
View article: Hydroxychloroquine as an add-on therapy for the induction therapy of MPO-AAV: a retrospective observational cohort study
Hydroxychloroquine as an add-on therapy for the induction therapy of MPO-AAV: a retrospective observational cohort study Open
Background The remission rate of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients who received standard induction therapy is far from satisfactory. Improving the remission rate of MPO-AA…
View article: Editorial: Innate immunity in vasculitis
Editorial: Innate immunity in vasculitis Open
Citation: De Souza AWS, Ooi JD, Misra DP, Zhong Y and Brown KL (2024) Editorial: Innate immunity in vasculitis. Front. Immunol. 15:1432069. doi: 10.3389/fimmu.2024.1432069
View article: Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA
Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA Open
Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) patients with dual positivity for proteinase 3-ANCA (PR3-ANCA) and myeloperoxidase-ANCA (MPO-ANCA) are uncommon. We aimed to investigate these idiopathic double-positi…
View article: The Influence of Cross-Reactive T Cells in COVID-19
The Influence of Cross-Reactive T Cells in COVID-19 Open
Memory T cells form from the adaptive immune response to historic infections or vaccinations. Some memory T cells have the potential to recognise unrelated pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and gen…
View article: The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease
The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease Open
Inflammatory bowel disease (IBD) is becoming more common in the Western world due to changes in diet-related microbial dysbiosis, genetics and lifestyle. Incidences of gut permeability can predate IBD and continued gut barrier disruptions …
View article: Epithelially Restricted Interferon Epsilon Protects Against Colitis
Epithelially Restricted Interferon Epsilon Protects Against Colitis Open
Overall, we have shown IFNε expression in intestinal epithelium and its critical role in gut homeostasis. Given its known role in the female reproductive tract, we now show IFNε has a protective role across multiple mucosal surfaces.
View article: Development of a radiomics nomogram to predict the treatment resistance of Chinese MPO-AAV patients with lung involvement: a two-center study
Development of a radiomics nomogram to predict the treatment resistance of Chinese MPO-AAV patients with lung involvement: a two-center study Open
Background Previous studies from our group and other investigators have shown that lung involvement is one of the independent predictors for treatment resistance in patients with myeloperoxidase (MPO)–anti-neutrophil cytoplasmic antibody (…
View article: Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury
Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury Open
Background: Ischemic acute kidney injury (AKI) is a common syndrome associated with considerable mortality and healthcare costs. Up to now, the underlying pathogenesis of ischemic AKI remains incompletely understood, and specific strategie…
View article: NETosis as an oncologic therapeutic target: a mini review
NETosis as an oncologic therapeutic target: a mini review Open
Neutrophil Extracellular Traps (NETs) are a key form of pro-inflammatory cell death of neutrophils characterized by the extrusion of extracellular webs of DNA containing bactericidal killing enzymes. NETosis is heavily implicated as a key …
View article: Smith-specific regulatory T cells halt the progression of lupus nephritis
Smith-specific regulatory T cells halt the progression of lupus nephritis Open
Antigen-specific regulatory T cells (Tregs) suppress pathogenic autoreactivity and are potential therapeutic candidates for autoimmune diseases such as systemic lupus erythematosus (SLE). Lupus nephritis is associated with autoreactivity t…
View article: Sex disparities in clinicopathological features and outcomes of patients with myeloperoxidase-ANCA-associated vasculitis: A retrospective study of 366 cases in a single Chinese center
Sex disparities in clinicopathological features and outcomes of patients with myeloperoxidase-ANCA-associated vasculitis: A retrospective study of 366 cases in a single Chinese center Open
There are a few studies that reported sex disparities in clinical features, pathological features and outcomes among ANCA-associated vasculitis (AAV) patients, but studies focusing on sex-specific differences of myeloperoxidase (MPO)-AAV p…
View article: Clinical features and prognosis of MPO-ANCA and anti-GBM double-seropositive patients
Clinical features and prognosis of MPO-ANCA and anti-GBM double-seropositive patients Open
Background Several lines of evidence implicate that there are distinct differences between patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) antibody double-seroposit…
View article: Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy
Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy Open
To date, the pathogenesis of hepatitis B virus (HBV)-associated membranous nephropathy (MN) remains elusive. This study aimed to decipher the etiopathogenesis of HBV-associated MN by performing single-cell RNA sequencing (scRNA-seq) of kid…
View article: Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation
Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation Open
Studies have highlighted a critical role for autophagy in the regulation of multiple cytokines. Autophagy inhibits the release of interleukin (IL)‐1 family cytokines, including IL‐1α, IL‐1β and IL‐18, by myeloid cells. This, in turn, impac…
View article: Improving cell viability using counterflow centrifugal elutriation
Improving cell viability using counterflow centrifugal elutriation Open
Counterflow centrifugal elutriation can be added as an integrated step to the automated wash-and-concentrate protocol for cell manufacturing to remove dead cells and improve cell viability of the final product.
View article: High levels of platelet-to-lymphocyte ratio may predict reduced risk of end stage of renal disease in Chinese patients with MPO-ANCA associated vasculitis
High levels of platelet-to-lymphocyte ratio may predict reduced risk of end stage of renal disease in Chinese patients with MPO-ANCA associated vasculitis Open
OBJECTIVE: Platelet-to-lymphocyte ratio (PLR) has recently been investigated as a new inflammatory marker in many inflammatory diseases, including systemic lupus erythematosus and immunoglobulin A vasculitis. However, there were very few r…
View article: Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria
Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria Open
Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes. Here …
View article: Patient Survival Between Hemodialysis and Peritoneal Dialysis Among End-Stage Renal Disease Patients Secondary to Myeloperoxidase-ANCA-Associated Vasculitis
Patient Survival Between Hemodialysis and Peritoneal Dialysis Among End-Stage Renal Disease Patients Secondary to Myeloperoxidase-ANCA-Associated Vasculitis Open
Background A significant proportion of anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis eventually progresses to end-stage renal disease (ESRD) thus requiring long-term dialysis. There is no consensus about which d…
View article: Editorial: The Network of Inflammatory Mechanisms in Kidney Disease: Mechanism and New Therapeutic Agents
Editorial: The Network of Inflammatory Mechanisms in Kidney Disease: Mechanism and New Therapeutic Agents Open
The Network of Inflammatory Mechanisms in Kidney Disease: Mechanism and NewIt has been shown that the progression of kidney disease in humans and animal models usually involves the sustained activation of a number of signaling pathways. In…