Daniel Oreper
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View article: Erratum for Perkowski et al., “The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection”
Erratum for Perkowski et al., “The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection” Open
Erratum for “The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection”
View article: Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming
Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming Open
Background Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA). One approach to prime TA-reactive T-cells is to administer immunostimulatory molecules, cel…
View article: Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Figure from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Supplementary Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
View article: Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in approximately 10% of cases and is thought to represent more advanced disease. The intravascular nature of VTT suggests that it may serve a…
View article: Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma Open
Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in approximately 10% of cases and is thought to represent more advanced disease. The intravascular nature of VTT suggests that it may serve a…
View article: Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies
Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies Open
Background Individualized neoantigen-specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challe…
View article: Origins and timing of emerging lesions in advanced renal cell carcinoma
Origins and timing of emerging lesions in advanced renal cell carcinoma Open
Purpose Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in 4-10% of cases and is associated with advanced disease. RCC with VTT and distant metastasis represents a unique clinical entity, a…
View article: Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies
Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies Open
Individualized neoantigen specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challenges. To ch…
View article: Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel <i>Xce</i> allele associated with copy number changes
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel <i>Xce</i> allele associated with copy number changes Open
Female mammals are functional mosaics of their parental X-linked gene expression due to X chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in each cell during embryogenesis and that state is maintained c…
View article: Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel<i>Xce</i>allele associated with copy number changes
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel<i>Xce</i>allele associated with copy number changes Open
Female mammals are functional mosaics of their parental X-linked gene expression due to X chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in each cell during embryogenesis and that state is maintained c…
View article: Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice
Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice Open
Women are at an increased risk for developing affective disorders during times of hormonal flux, including menopause when the ovaries cease production of estrogen. However, while all women undergo menopause, not all develop an affective di…
View article: Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders
Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders Open
The Collaborative Cross (CC) is a panel of recently established multiparental recombinant inbred mouse strains. For the CC, as for any multiparental population (MPP), effective experimental design and analysis benefit from detailed knowled…
View article: Bayesian decision theoretic design of two-founder experimental crosses given diallel data
Bayesian decision theoretic design of two-founder experimental crosses given diallel data Open
In designing experimental crosses of inbred strains of model organisms, researchers must make a number of decisions. These include the selection of the appropriate strains, the cross design ( eg . F2 intercross), and the number of progeny …
Reciprocal F1 Hybrids of Two Inbred Mouse Strains Reveal Parent-of-Origin and Perinatal Diet Effects on Behavior and Expression Open
Parent-of-origin effects (POE) in mammals typically arise from maternal effects or imprinting. In some instances, such POE have been associated with psychiatric disorders, as well as with changes in a handful of animal behaviors. However, …
View article: Reciprocal F1 hybrids of two inbred mouse strains reveal parent-of-origin and perinatal diet effects on behavior and expression
Reciprocal F1 hybrids of two inbred mouse strains reveal parent-of-origin and perinatal diet effects on behavior and expression Open
Parent-of-origin effects (POEs) in mammals typically arise from maternal effects or from imprinting. Mutations in imprinted genes have been associated with psychiatric disorders, as well as with changes in a handful of animal behaviors. No…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression
Reciprocal F1 Hybrids Of Two Inbred Mouse Strains Reveal Parent-Of-Origin And Perinatal Diet Effects On Behavior And Expression Open
Raw data and statistical analyses from an experiment to study parent-of-origin and diet-by-parent-of-origin effects on expression and behavior. In this experiment, female NOD/ShiLtJ x C57Bl/6J and C57Bl/6J x NOD/ShiLtJ mice were exposed in…
View article: Perinatal nutrition interacts with genetic background to alter behavior in a parent‐of‐origin‐dependent manner in adult Collaborative Cross mice
Perinatal nutrition interacts with genetic background to alter behavior in a parent‐of‐origin‐dependent manner in adult Collaborative Cross mice Open
Previous studies in animal models and humans have shown that exposure to nutritional deficiencies in the perinatal period increases the risk of psychiatric disease. Less well understood is how such effects are modulated by the combination …