Daniel P. Beavers
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View article: Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis
Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis Open
The purpose of this exploratory post hoc analysis was to study the impact of semaglutide on measures of bone health in older adults. Data were collected from a 20-week pilot trial (NCT05786521), which randomized 20 older adults (72.7 ± 4.8…
View article: Weighted Vest Use or Resistance Exercise to Offset Weight Loss–Associated Bone Loss in Older Adults
Weighted Vest Use or Resistance Exercise to Offset Weight Loss–Associated Bone Loss in Older Adults Open
Importance Weight loss (WL) in older adults is associated with bone loss, increasing the risk of fracture. Because skeletal tissue is responsive to mechanical stress, replacing lost weight externally may be an innovative way to minimize WL…
View article: Does weighted vest use during weight loss influence long-term weight loss maintenance? A pilot study in older adults living with obesity and osteoarthritis
Does weighted vest use during weight loss influence long-term weight loss maintenance? A pilot study in older adults living with obesity and osteoarthritis Open
View article: Musculoskeletal characteristics in older adults with overweight or obesity: <scp>INVEST</scp> in Bone Health trial baseline analysis
Musculoskeletal characteristics in older adults with overweight or obesity: <span>INVEST</span> in Bone Health trial baseline analysis Open
Objective The objective of this study was to examine associations of computed tomography (CT)‐derived musculoskeletal measures with demographics and traditional musculoskeletal characteristics. Methods The Incorporating Nutrition, Vests, E…
View article: Air Pollution is Linked to Divergent Cortical Thickness Patterns in Brain Regions Vulnerable to Alzheimer's Disease
Air Pollution is Linked to Divergent Cortical Thickness Patterns in Brain Regions Vulnerable to Alzheimer's Disease Open
View article: <scp>G</scp><scp>LP1Ra</scp>‐based therapies and <scp>DXA</scp>‐acquired musculoskeletal health outcomes: a focused meta‐analysis of placebo‐controlled trials
<span>G</span><span>LP1Ra</span>‐based therapies and <span>DXA</span>‐acquired musculoskeletal health outcomes: a focused meta‐analysis of placebo‐controlled trials Open
Objective The objective of this study was to evaluate the effect of glucagon‐like peptide‐1 receptor agonist (GLP1Ra)‐based therapies on change in dual‐energy x‐ray absorptiometry (DXA)‐acquired lean mass (LM) or bone mineral density (BMD)…
View article: THE INCORPORATING NUTRITION, VESTS, EDUCATION, AND STRENGTH TRAINING IN BONE HEALTH RANDOMIZED TRIAL RESULTS
THE INCORPORATING NUTRITION, VESTS, EDUCATION, AND STRENGTH TRAINING IN BONE HEALTH RANDOMIZED TRIAL RESULTS Open
Intentional weight loss (WL) in older adults is associated with bone loss, increasing risk of fracture. As skeletal tissue is responsive to mechanical stress, replacing lost weight externally may be an innovative way to minimize WL-associa…
View article: Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity
Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity Open
Objective The study objective was to determine whether the clinical response of older adults with knee osteoarthritis and overweight or obesity to 18 months of diet and exercise (D + E) or attention control (C) interventions differed betwe…
View article: Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula
Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula Open
View article: Associations between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women
Associations between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women Open
Background: Elucidating associations between exposures to ambient air pollutants and profiles of cognitive performance may provide insight into neurotoxic effects on the aging brain. Objective: We examined associations between empirically …
View article: Outdoor air pollution exposure and inter-relation of global cognitive performance and emotional distress in older women
Outdoor air pollution exposure and inter-relation of global cognitive performance and emotional distress in older women Open
View article: Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study
Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study Open
Background Late-life exposure to ambient air pollution is a modifiable risk factor for dementia, but epidemiological studies have shown inconsistent evidence for cognitive decline. Air quality (AQ) improvement has been associated with impr…
View article: Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest-Old Women
Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest-Old Women Open
BACKGROUND/OBJECTIVES: Exposure to air pollution may contribute to both increasing depressive symptoms and decreasing episodic memory in older adulthood, but few studies have examined this hypothesis in a longitudinal context. Accordingly,…
View article: Ambient air pollution and long-term trajectories of episodic memory decline among older women in the whims-echo cohort
Ambient air pollution and long-term trajectories of episodic memory decline among older women in the whims-echo cohort Open
BACKGROUND: Episodic memory decline varies by age and underlying neuropathology. Whether ambient air pollution contributes to the heterogeneity of episodic memory decline in older populations remains unclear. OBJECTIVES: We estimated assoc…
View article: Association of improved air quality with lower dementia risk in older women
Association of improved air quality with lower dementia risk in older women Open
Late-life ambient air pollution is a risk factor for brain aging, but it remains unknown if improved air quality (AQ) lowers dementia risk. We studied a geographically diverse cohort of older women dementia free at baseline in 2008 to 2012…
View article: Associations between air pollution exposure and empirically derived subtypes of mild cognitive impairment in older women
Associations between air pollution exposure and empirically derived subtypes of mild cognitive impairment in older women Open
Background Exposure to air pollution in older adulthood is a novel risk factor for mild cognitive impairment (MCI). MCI is a heterogenous construct with different subtypes likely reflecting different disease etiologies. Understanding if lo…
View article: Subtle cognitive difficulties increase risk of neurodegeneration, incident mild cognitive impairment, and dementia in older women.
Subtle cognitive difficulties increase risk of neurodegeneration, incident mild cognitive impairment, and dementia in older women. Open
Background Identifying individuals with preclinical Alzheimer’s disease and related disorders (ADRD) is important for prevention and eventual treatment. Here we aimed to integrate overall test performance with episodic memory process score…
View article: Air pollution exposure is associated with widespread cortical thinning in cognitively unimpaired older women
Air pollution exposure is associated with widespread cortical thinning in cognitively unimpaired older women Open
Background Late‐life ambient air pollution exposures are associated with increased Alzheimer’s disease (AD) risk 1 . Cortical thinning in temporal areas vulnerable to AD is associated with memory decline, neuropathological changes, and inc…
View article: Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy
Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy Open
Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm (PM 2.5 ) and nitrogen dioxide (NO 2 ), are environmental risk factors for Alzheimer’s disease and related dementia. The medial temporal lob…
View article: Association between late-life air pollution exposure and medial temporal lobe atrophy in older women
Association between late-life air pollution exposure and medial temporal lobe atrophy in older women Open
Background Ambient air pollution exposures increase risk for Alzheimer’s disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on …
View article: The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis: Design and rationale
The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis: Design and rationale Open
ClinicalTrials.gov Identifier: NCT05946044.
View article: Clinical, <scp>Health‐Related</scp> Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis
Clinical, <span>Health‐Related</span> Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis Open
Objective The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. Methods This cross‐sectional analy…
View article: Ambient Air Quality and Fatal Asthma Exacerbations among Children in North Carolina
Ambient Air Quality and Fatal Asthma Exacerbations among Children in North Carolina Open
Background: Little is known about the role of air quality in fatal asthma exacerbations among children. Methods: We collected information about 80 deaths that occurred in North Carolina from 2001 through 2016, among children aged 5–17 year…
View article: Air pollution exposure is associated with lower positive affect in older women
Air pollution exposure is associated with lower positive affect in older women Open
View article: Associations between air pollution exposure and gait speed in older women: partial mediation by structural brain atrophy
Associations between air pollution exposure and gait speed in older women: partial mediation by structural brain atrophy Open
View article: Application of the D<sub>3</sub>‐creatine muscle mass assessment tool to a geriatric weight loss trial: A pilot study
Application of the D<sub>3</sub>‐creatine muscle mass assessment tool to a geriatric weight loss trial: A pilot study Open
Background Traditionally, weight loss (WL) trials utilize dual energy X‐ray absorptiometry (DXA) to measure lean mass. This method assumes lean mass, as the sum of all non‐bone and non‐fat tissue, is a reasonable proxy for muscle mass. In …
View article: Strategies to reduce the onset of sleeve gastrectomy associated bone loss (STRONG BONES): Trial design and methods
Strategies to reduce the onset of sleeve gastrectomy associated bone loss (STRONG BONES): Trial design and methods Open
Results from the STRONG BONES trial have the potential to influence current clinical practice by determining the ability of bisphosphonate use to mitigate bone loss and concomitant fracture risk in middle-aged and older SG patients.
View article: Association of antenatal corticosteroids with kidney function in adolescents born preterm with very low birth weight
Association of antenatal corticosteroids with kidney function in adolescents born preterm with very low birth weight Open
View article: Effect of Baseline BMI and IL-6 Subgroup Membership on Gait Speed Response to Caloric Restriction in Older Adults with Obesity
Effect of Baseline BMI and IL-6 Subgroup Membership on Gait Speed Response to Caloric Restriction in Older Adults with Obesity Open
View article: Strategies to Reduce the Onset of Sleeve Gastrectomy Associated Bone Loss (STRONG BONES): Trial Design and Methods
Strategies to Reduce the Onset of Sleeve Gastrectomy Associated Bone Loss (STRONG BONES): Trial Design and Methods Open