Daniel P. Chupp
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View article: Neutralization of recent SARS-CoV-2 variants by genetically and structurally related mAbs of the pemivibart lineage
Neutralization of recent SARS-CoV-2 variants by genetically and structurally related mAbs of the pemivibart lineage Open
Pemivibart is a monoclonal antibody therapy currently under Emergency Use Authorization for the for the pre-exposure prophylaxis of coronavirus disease 2019 (COVID-19) in adults and adolescents over 12 years of age with certain immunocompr…
View article: A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses Open
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated Kit W-41J mutant immunodefi…
View article: Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells Open
Maturation of an antibody response entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation and generation of memory B cells, and is thought to be generally dependent on T cell help. We show he…
View article: Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells Open
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is thought to require T cell help. We showed that B cell Toll…
View article: Direct Activation of Toll-like Receptor 4 Signaling in Group 2 Innate Lymphoid Cells Contributes to Inflammatory Responses of Allergic Diseases
Direct Activation of Toll-like Receptor 4 Signaling in Group 2 Innate Lymphoid Cells Contributes to Inflammatory Responses of Allergic Diseases Open
Group 2 innate lymphoid cells (ILC2) play a critical role in type 2 immunity. Although their classical activators are known to be host epithelial-derived alarmin cytokines released from tissue damage at barrier sites during microbial infec…
View article: Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4 Open
IgA is the predominant antibody isotype at intestinal mucosae, where it plays a critical role in homeostasis and provides a first line of immune protection. Dysregulation of IgA production, however, can contribute to immunopathology, parti…
View article: STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33–driven type 2 immunopathology
STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33–driven type 2 immunopathology Open
2'3'-cGAMP is known as a nonclassical second messenger and small immune modulator that possesses potent antitumor and antiviral activities via inducing the stimulator of IFN genes-mediated (STING-mediated) signaling pathway. However, its f…
View article: Epigenetics of the antibody and autoantibody response
Epigenetics of the antibody and autoantibody response Open
B cell differentiation driven by microbial antigens leads to production of anti-microbial antibodies, such as those neutralizing viruses, bacteria or bacterial toxin, that are class-switched (IgG and IgA) and somatically hypermutated (matu…
View article: Non-canonical Activation of Human Group 2 Innate Lymphoid Cells by TLR4 Signaling
Non-canonical Activation of Human Group 2 Innate Lymphoid Cells by TLR4 Signaling Open
Group 2 innate lymphoid cells (ILC2) are emerging as a critical player in type 2 immunity at barrier sites in response to microbial infections and allergen exposures. Although their classical activators are known to be host epithelial-deri…
View article: B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response Open
Sirt1 mediates epigenetic modulation of B cell AID expression and antibody response by deacetylating histones, Dnmt1 and NF-κB p65.
View article: Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a
Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a Open
Estrogen contributes to females' strong antibody response to microbial vaccines and proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in females. We have hypothesized that this is due to estrogen-mediated pot…