Daniel P. Koster
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View article: Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins Open
Targeted protein degradation (TPD) using PROteolysis TArgeting Chimeras (PROTACs) is a rapidly emerging therapeutic strategy for difficult-to-drug cytosolic proteins. PROTACs are heterobifunctional small molecules that bridge the target wi…