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View article: Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cells
Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cells Open
Genome-editing technologies have enabled the clinical development of allogeneic cellular therapies, yet the optimal gene-editing modality for multiplex editing of therapeutic T cell product manufacturing remains elusive. In this study, we …
View article: Uncertainty Quantification of Fatigue Behavior of Rough AM Surfaces and Microstructures to Enable Hydrogen Gas Turbine
Uncertainty Quantification of Fatigue Behavior of Rough AM Surfaces and Microstructures to Enable Hydrogen Gas Turbine Open
Modifying fossil-fueled industrial gas turbines to utilize low or zero-carbon fuels, such as hydrogen or hydrogen-natural gas blends, is a complex endeavor. The successful implementation of this technology hinges on three key design criter…
Duodenal hematoma following endoscopic duodenal biopsy in an adult requiring arterial embolization and surgical evacuation: a case report and review of the literature Open
A 21-year-old man presented with severe abdominal pain four days after undergoing upper endoscopy with duodenal biopsies and was found to have an intramural duodenal hematoma. Symptoms progressed after attempts at diet advancement, and rep…
View article: Novel Hot Gas Components for Gas Turbine Engines Enabled by Materials and Additive Manufacturing Process Development
Novel Hot Gas Components for Gas Turbine Engines Enabled by Materials and Additive Manufacturing Process Development Open
Additive Manufacturing (AM), also known as 3D printing, has emerged as a manufacturing method that enables new design freedom for gas turbine engine manufacturers. However, the material selection for AM processable high-temperature super a…
Microstructural control of LPBF Inconel 718 through post processing of intentionally placed AM discontinuity distributions Open
A major untapped potential of laser powder bed fusion (LPBF) is the ability to additively manufacture (AM) parts with site-specific properties. However, robust methods of improving performance and manufacturing efficiency via spatial varia…
View article: Surface roughness-informed fatigue life prediction of L-PBF Hastelloy X at elevated temperature
Surface roughness-informed fatigue life prediction of L-PBF Hastelloy X at elevated temperature Open
Additive manufacturing, especially laser powder bed fusion (L-PBF), is widely used for fabricating metal parts with intricate geometries. However, parts produced via L-PBF suffer from varied surface roughness which affects the dynamic or f…
Full Scale Engine Demonstration of Additively Manufactured High Gamma Prime Turbine Blade Open
Additive manufacturing (AM), also known as 3D printing, is a rapidly developing technology with tremendous potential in both developmental and production applications. Solar Turbines Incorporated is committed to AM technology development f…
Assessment of High Gamma Prime Ni-base Superalloy Processability, Geometric Accuracy, and Component Fabricability (CRADA NFE-17-06955 Final Report) Open
Additive manufacturing (AM), also known as 3D printing, is a rapidly developing technology with tremendous potential in both developmental and production applications. Solar Turbines Incorporated is committed to AM technology for gas turbi…
Comparison of Electron Beam and Laser Beam Powder Bed Fusion Additive Manufacturing Process for High Temperature Turbine Component Materials, Phase II. CRADA Final Report Open
The evolving additive manufacturing (AM) technology is now at the point where some metallic turbine components are being fabricated for both development and production purposes. The goal of this phase II project is to continue the evaluati…
CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation Open
Summary Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. The mechanism, however, is only partially resolved, and unclear if it is conserved among the four remodeller families. Here we use single-molecul…
The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin Open
One of the most intensively studied chromatin binding factors is HP1α. HP1α is associated with silenced, heterochromatic regions of the genome and binds to H3K9me3. While H3K9me3 is necessary for HP1α recruitment to heterochromatin, it is …
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes Open
The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome wh…
A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B Open
The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B appeared late in evolution and is most highly expressed in the testis followed by t…
Author response: Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The yeast Chd1 protein acts…
Y-TZP zirconia regeneration firing: Microstructural and crystallographic changes after grinding Open
This study evaluated microstructural and crystallographic phase changes after grinding (G) and regeneration firing/anneling (R) of Y-TZP ceramics. Thirty five bars (LavaTM and Ice Zirkon) were divided: Y-TZP pre-sintered, control (C), rege…
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes Open
The yeast Chd1 protein acts to position nucleosomes across genomes. Here we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state the DNA binding domain contacts the edge of the nucleosome whil…
Comparison of electron beam and laser beam powder bed fusion additive manufacturing process for high temperature turbine component materials Open
The evolving 3D printer technology is now at the point where some turbine components could be additive manufactured (AM) for both development and production purposes. However, this will require a significant evaluation program to qualify t…