Santiago Daniel Palma
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View article: Sustained-Release Biodegradable Intracameral Implants Containing Dexamethasone and Moxifloxacin: Development and In Vivo Primary Assessment
Sustained-Release Biodegradable Intracameral Implants Containing Dexamethasone and Moxifloxacin: Development and In Vivo Primary Assessment Open
Background/Objectives: We report the development of a novel intraocular sustained-release implantable pharmaceutical formulation, designed to be placed in the anterior chamber of the eye after cataract surgery. The device is intended to re…
View article: A Decision Tree for the Rational Selection of Mathematical Models in Drug Dissolution and Release Studies
A Decision Tree for the Rational Selection of Mathematical Models in Drug Dissolution and Release Studies Open
Background/Objectives: In vitro dissolution tests are an essential tool in pharmaceutical development, allowing for the analysis of biopharmaceutical properties, understanding release mechanisms, and comparing formulations. The wide variet…
View article: Triamcinolone-loaded nanocarriers: a novel strategy to mitigate cognitive and emotional sequelae induced by traumatic brain injury via modulation of oxidative stress
Triamcinolone-loaded nanocarriers: a novel strategy to mitigate cognitive and emotional sequelae induced by traumatic brain injury via modulation of oxidative stress Open
Introduction Traumatic brain injury is the leading cause of death and disability in individuals under 40 years old. It induces various neuropathological outcomes, including cognitive, emotional, and physiological deficits, likely linked to…
View article: 3D Printing of PVA Capsular Devices for Applications in Compounding Pharmacy: Stability Evaluation and In Vivo Performance
3D Printing of PVA Capsular Devices for Applications in Compounding Pharmacy: Stability Evaluation and In Vivo Performance Open
Background: The personalization of medication through 3D printing enables the development of capsular devices (CDs) tailored to patient-specific needs. This study aimed to evaluate the stability and in vivo performance of 3D-printed polyvi…
View article: Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo
Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo Open
Introduction Vascular endothelial growth factor (VEGF) inhibition is currently the first-line therapy for various retinal vascular disorders, however there is a strong need to develop novel therapies to target other molecules involved in t…
View article: Microencapsulation techniques for developing cannabidiol formulations: a review
Microencapsulation techniques for developing cannabidiol formulations: a review Open
Cannabidiol (CBD), extracted from Cannabis sativa L., holds therapeutic promise without inducing psychoactive effects seen with Δ9-tetrahydrocannabinol. Its interaction with the endocannabinoid system plays a pivotal role in regulating moo…
View article: 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release
3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release Open
Background: Gold nanoparticles can generate heat upon exposure to radiation due to their plasmonic properties, which depend on particle size and shape. This enables precise control over the release of active substances from polymeric pharm…
View article: Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets
Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets Open
Aim: This study focused on evaluating the influence of geometric dimensions on the drug release kinetics of 3D-printed tablets.Materials & methods: An ink based on Gelucire 50/13 was prepared to print ivermectin-loaded tablets. The ink was…
View article: A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory scale
A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory scale Open
Poor aqueous solubility of preexisting and emerging drug molecules is a common issue faced in the field of pharmaceutics. To address this, particle size reduction techniques, including drug micro- and nanonisation have been widely employed…
View article: Organic solvent-free benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease
Organic solvent-free benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease Open
Aim: Benznidazole (BNZ), a class-II drug, is the primary treatment for Chagas disease, but its low aqueous solubility presents challenges in formulation and efficacy. Nanosuspensions (NS) could potentially address these issues.Methods: BNZ…
View article: Comparison of ER and HER2 expression in screen-detected and symptomatic invasive breast carcinomas: an audit
Comparison of ER and HER2 expression in screen-detected and symptomatic invasive breast carcinomas: an audit Open
Introduction and objectives: Invasive breast cancer (IBC) is the most common cancer among women, and the majority overexpress ER while a minority expresses HER2. Reliable receptor assessment is crucial to minimize false-negative and false-…
View article: Formulation of Sustainable Biopolymer-Based Nanoparticles Obtained via Media Milling for Chia Oil Vehiculization in Pickering Emulsions
Formulation of Sustainable Biopolymer-Based Nanoparticles Obtained via Media Milling for Chia Oil Vehiculization in Pickering Emulsions Open
Sustainable corn starch nanoparticles were prepared using media milling to stabilize omega-3-rich Pickering emulsions based on chia oil. The milling conditions were as follows: 24 h (milling time), 0.4–0.6 mm (bead diameter), 1600 rpm (imp…
View article: Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods Open
The effectiveness of dry-ball and wet-bead nano-milling methods in producing nanocrystals of glyburide with increased dissolution rate has been compared. A full factorial design was applied to both methods to systematically evaluate the ef…
View article: Application of 20% silver nanoclusters in polymethacrylic acid on simulated dentin caries; its penetration depth and effect on surface hardness
Application of 20% silver nanoclusters in polymethacrylic acid on simulated dentin caries; its penetration depth and effect on surface hardness Open
The aims of this study were: To evaluate the surface hardness of simulated dentin caries lesions treated with either silver nanoclusters (AgNCls) synthesized in polymethacrylic acid (PMAA) or 38% silver diammine fluoride (SDF), as well as …
View article: Organic solvent-free Benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease
Organic solvent-free Benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease Open
Benznidazole —a class II/IV as per the Biopharmaceutics Classification System—is the drug of choice for treating Chagas disease; however, its low aqueous solubility is a limiting factor that reduces its dissolution rate in a conventional a…
View article: Enhancing the Functional Properties of Tea Tree Oil: In Vitro Antimicrobial Activity and Microencapsulation Strategy
Enhancing the Functional Properties of Tea Tree Oil: In Vitro Antimicrobial Activity and Microencapsulation Strategy Open
In the context of addressing antimicrobial drug resistance in periocular infections, Tea Tree Oil (TTO) has emerged as a promising therapeutic option. This study aimed to assess the efficacy of TTO against bacterial strains isolated from o…
View article: Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery.
Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery. Open
The challenge of low water solubility in pharmaceutical science profoundly impacts drug absorption and therapeutic effectiveness. Nanocrystals (NC), consisting of drug molecules and stabilizing agents, offer a promising solution to enhance…
View article: Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)
Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP) Open
Domperidone (DOM) is a drug commonly used to treat nausea and vomiting, as well as gastrointestinal disorders. However, its low solubility and extensive metabolism pose significant administration challenges. In this study, we aimed to impr…
View article: 3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP)
3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP) Open
Niclosamide (NICLO) is a recognized antiparasitic drug being repositioned for Helicobacter pylori. The present work aimed to formulate NICLO nanocrystals (NICLO-NCRs) to produce a higher dissolution rate of the active ingredient and to inc…
View article: Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications
Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications Open
Polyphenols comprise a number of natural substances, such as flavonoids, that show interesting biological effects. Among these substances is naringin, a naturally occurring flavanone glycoside found in citrus fruits and Chinese medicinal h…
View article: Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration
Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration Open
Triamcinolone acetonide (TA) is a powerful anti-inflammatory drug used in the treatment of inflammatory ocular disorders; however, its poor aqueous solubility and ocular anatomical barriers hinder optimal treatment. The aim of this work wa…
View article: Preparation of Corn Starch Nanoparticles by Wet-Stirred Media Milling for Chia Oil Vehiculization
Preparation of Corn Starch Nanoparticles by Wet-Stirred Media Milling for Chia Oil Vehiculization Open
An organic-free method was applied to produce corn starch nanoparticles, which were designed to stabilize Pickering emulsions containing chia oil, the richest vegetable source of omega-3 fatty acids. The liquid stream resulting from a labo…
View article: Design and analysis of an efficient glaucoma model for evaluation of pharmacological trials
Design and analysis of an efficient glaucoma model for evaluation of pharmacological trials Open
Glaucoma is a multifactorial progressive optic neuropathy whose main risk factor is intraocular hypertension (IOH). It generates a loss of nerves and is the primary cause of irreversible blindness worldwide. The objective of this work was …