Daniel J. Pearce
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View article: 3588 CLOX and neurotox: utility of clock drawing to monitor immune effector cell-associated neurotoxicity syndrome following chimeric antigen receptor T-cell therapy
3588 CLOX and neurotox: utility of clock drawing to monitor immune effector cell-associated neurotoxicity syndrome following chimeric antigen receptor T-cell therapy Open
View article: CS5 Cognitive recovery following immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy
CS5 Cognitive recovery following immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy Open
View article: Irreversibility and symmetry breaking in the creation and annihilation of defects in active living matter
Irreversibility and symmetry breaking in the creation and annihilation of defects in active living matter Open
Active living matter continuously creates and annihilates topological defects in a process that remains poorly understood. Here, we investigate these dynamics in two distinct active living systems, swarming bacteria and human bronchial epi…
View article: <scp>CLOX</scp> and neurotox: Utility of the clock drawing task in monitoring for immune effector cell‐associated neurotoxicity syndrome following chimeric antigen receptor T‐cell therapy
<span>CLOX</span> and neurotox: Utility of the clock drawing task in monitoring for immune effector cell‐associated neurotoxicity syndrome following chimeric antigen receptor T‐cell therapy Open
Summary Immune effector cell‐associated neurotoxicity syndrome (ICANS)‐associated cognitive impairment is common in patients who receive chimeric antigen receptor T‐cell (CAR‐T) therapy. This study evaluated the utility of the clock drawin…
View article: Plantar fasciitis is the predominant ultrasonographic diagnosis in Thoroughbred racehorses presenting with curb: 32 cases in 27 horses (2006-2025)
Plantar fasciitis is the predominant ultrasonographic diagnosis in Thoroughbred racehorses presenting with curb: 32 cases in 27 horses (2006-2025) Open
View article: Topology changes of <i>Hydra</i> define actin orientation defects as organizers of morphogenesis
Topology changes of <i>Hydra</i> define actin orientation defects as organizers of morphogenesis Open
Hydra regenerates one head when cut, but how forces shaping the head are coordinated remains unclear. Soft compression of Hydra ’s head-regenerating tissues induces the formation of viable, two-headed animals. Compression creates new topol…
View article: Passive Defect Driven Morphogenesis in Nematic Membranes
Passive Defect Driven Morphogenesis in Nematic Membranes Open
Orientational order is a common feature of many biological and synthetic materials. Topological defects are discontinuities in this order that are often coupled to geometric features of the materials. Here, we study the equilibrium shapes …
View article: Topological defects lead to energy transfer in active nematics
Topological defects lead to energy transfer in active nematics Open
Active nematics are fluids in which the components have nematic symmetry and are driven out of equilibrium due to the microscopic generation of an active stress. When the active stress is high, it drives flows in the nematic and can lead t…
View article: Optimal self-assembly pathways towards colloidal lattices with tunable flexibility
Optimal self-assembly pathways towards colloidal lattices with tunable flexibility Open
Flexibility governs the many properties of materials and is crucial for the function of proteins and biopolymers. However, how the self-assembly of flexibly bonded particles can lead to larger structures with global reconfigurability is un…
View article: Topology changes of the regenerating<i>Hydra</i>define actin nematic defects as mechanical organizers of morphogenesis
Topology changes of the regenerating<i>Hydra</i>define actin nematic defects as mechanical organizers of morphogenesis Open
Hydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces th…
View article: Topological defects in multi-layered swarming bacteria
Topological defects in multi-layered swarming bacteria Open
Topological defects, which are singular points in a director field, play a major role in shaping active systems. Here, we experimentally study topological defects and the flow patterns around them, that are formed during the highly rapid d…
View article: Topological defects in multi-layered swarming bacteria
Topological defects in multi-layered swarming bacteria Open
Topological defects, which are singular points in a director field, play a major role in shaping the multi-layered structure of the swarm.
View article: Passive defect driven morphogenesis in nematic membranes
Passive defect driven morphogenesis in nematic membranes Open
Topological defects are ubiquitous on surfaces with orientational order fields. Here, we study equilibrium states generated by the feedback between geometry and nematic order on fluid membranes with an integer topological defect. When the …
View article: Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i>
Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i> Open
Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo
View article: Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i>
Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i> Open
Supplementary Figures 1-3, Table 1 from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo
View article: Data from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i>
Data from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i> Open
Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the survival and proliferation of human cancer. In this study, we report the in vitro and in vivo ac…
View article: Data from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i>
Data from AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells <i>In vitro</i> and <i>In vivo</i> Open
Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the survival and proliferation of human cancer. In this study, we report the in vitro and in vivo ac…
View article: Chiral Edge Current in Nematic Cell Monolayers
Chiral Edge Current in Nematic Cell Monolayers Open
Collectively migrating cells in living organisms are often guided by their local environment, including physical barriers and internal interfaces. Well-controlled in vitro experiments have shown that, when confined in adhesive stripes, mon…
View article: 3MO Genomic evolution of non-small cell lung cancer during the establishment and propagation of patient-derived xenograft models
3MO Genomic evolution of non-small cell lung cancer during the establishment and propagation of patient-derived xenograft models Open
View article: Chiral edge currents in nematic cell monolayers
Chiral edge currents in nematic cell monolayers Open
During metastatic dissemination, streams of cells collectively migrate through a network of narrow channels within the extracellular matrix, before entering into the blood stream. This strategy is believed to outperform other migration mod…
View article: Coupling topological defect phase to extrinsic curvature in nematic shells
Coupling topological defect phase to extrinsic curvature in nematic shells Open
In two dimensional nematics, topological defects are point like singularities with both a charge and a phase. We study topological defects within curved nematic textures on the surface of a cylinder. This allows us to isolate the effect of…
View article: Self-Assembly Dynamics of Reconfigurable Colloidal Molecules
Self-Assembly Dynamics of Reconfigurable Colloidal Molecules Open
Colloidal molecules are designed to mimic their molecular analogues through their anisotropic shape and interactions. However, current experimental realizations are missing the structural flexibility present in real molecules thereby restr…
View article: Self-Assembly Dynamics of Reconfigurable\nColloidal Molecules
Self-Assembly Dynamics of Reconfigurable\nColloidal Molecules Open
Colloidal molecules\nare designed to mimic their molecular analogues\nthrough their anisotropic shape and interactions. However, current\nexperimental realizations are missing the structural flexibility present\nin real molecules thereby r…
View article: Coupling the topological defect phase to the extrinsic curvature in nematic shells
Coupling the topological defect phase to the extrinsic curvature in nematic shells Open
Half integer topological defects within nematics on a curved surface. The extrinsic curvature induces a torque on the nematic which changes the shape of the defects and can induce a change in their phase.
View article: Confinement-induced self-organization in growing bacterial colonies
Confinement-induced self-organization in growing bacterial colonies Open
How do bacterial colonies orient and navigate through a narrow channel?
View article: Properties of twisted topological defects in 2D nematic liquid crystals
Properties of twisted topological defects in 2D nematic liquid crystals Open
We introduce the concept of twisted topological defects to describe out of phase defects in non-equilibrium systems. We investigate how these twists affect the relaxation dynamics of the nematic texture and demonstrate non-trivial, control…
View article: Chiral edge currents in confined fibrosarcoma cells
Chiral edge currents in confined fibrosarcoma cells Open
During metastatic dissemination, streams of cells collectively migrate through a network of narrow channels within the extracellular matrix, before entering into the blood stream. This strategy is believed to outperform other migration mod…
View article: Programming active metamaterials using topological defects
Programming active metamaterials using topological defects Open
Active metamaterials are able to modify their own shape, providing an exciting range of potential applications. Typically, an active metamaterial contains components able to generate force dipoles, the arrangement of which determines its m…
View article: Defect-driven shape transitions in elastic active nematic shells
Defect-driven shape transitions in elastic active nematic shells Open
Active matter is characterized by its ability to induce motion by self-generated stress. In the case of a solid, such motion can lead to shape transformations. The stress-generating components can be anisotropic endowing the material with …
View article: Orientational correlations in active and passive nematic defects
Orientational correlations in active and passive nematic defects Open
We investigate the emergence of orientational order among +1/2 disclinations in active nematic liquid crystals. Using a combination of theoretical and experimental methods, we show that +1/2 disclinations have short-range antiferromagnetic…