Daniel Pembaur
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Extracellular Vesicles Derived From Lipopolysaccharide‐Challenged Gingival Fibroblast Reveal Distinct miRNA Expression Patterns Associated With Reduced Cancer Survival Open
Objectives Periodontitis is a prevalent inflammatory disease with established systemic implications. Extracellular vesicles (EVs) have emerged as key mediators of intercellular communication, potentially linking periodontitis to systemic d…
Adenovirus type 34 and HVR1-deleted Adenovirus type 5 do not bind to PF4: clearing the path towards vectors without thrombosis risk Open
The adenoviral vector based AstraZeneca and Janssen COVID vaccines have been associated with rare cases of thrombosis, a condition which depends on adenovirus binding to the blood protein Platelet Factor 4 (PF4). In order to identify adeno…
An Adenoviral Vector as a Versatile Tool for Delivery and Expression of miRNAs Open
Only two decades after discovering miRNAs, our understanding of the functional effects of deregulated miRNAs in the development of diseases, particularly cancer, has been rapidly evolving. These observations and functional studies provide …
Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions Open
Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gen…
Abstracts of the 52nd Workshop for Pediatric Research Open
BackgroundA male dizygotic twin was delivered at a gestational age of 36 weeks in the Children's Hospital of the Helios Medical Centre Wuppertal, Witten/Herdecke University Hospital.Contrary to his brother the boy presented dystrophic at b…