Daniel Martı́nez
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View article: Corrigendum to ”Characterization and economic burden of KRASG12C-mutant lung cancer in real-world Spanish practice: a retrospective observational study (SILK study)” [Lung Cancer 206 (2025) 108677]
Corrigendum to ”Characterization and economic burden of KRASG12C-mutant lung cancer in real-world Spanish practice: a retrospective observational study (SILK study)” [Lung Cancer 206 (2025) 108677] Open
View article: Impact of piR_004530 reactivation in lung cancer: implications for recurrence and survival of lung squamous cell carcinoma patients
Impact of piR_004530 reactivation in lung cancer: implications for recurrence and survival of lung squamous cell carcinoma patients Open
Hsa_piR_004530 became reactivated in NSCLC, where it played a role as an oncogene, and its higher levels correlated with disease recurrence and shorter survival in SCC patients.
View article: Claudin 6 is a suitable target for CAR T-cell therapy in atypical teratoid/rhabdoid brain tumors and other pediatric solid tumors
Claudin 6 is a suitable target for CAR T-cell therapy in atypical teratoid/rhabdoid brain tumors and other pediatric solid tumors Open
Background Solid tumors comprise approximately 60% of all pediatric cancers. Relapsed or refractory tumors of the central nervous system (CNS), such as atypical teratoid/rhabdoid tumors (AT/RTs), are the leading cause of death in children …
View article: A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers
A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers Open
The Anaplastic Lymphoma Kinase ( ALK ) gene is a receptor tyrosine kinase (RTK) with expression restricted to the developing nervous system. Most neuroblastomas express native ALK protein on the cell surface and ALK is uniformly overexpres…
View article: NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas Open
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing events affecting extracellular protein do…
View article: Characterization and economic burden of KRASG12C-mutant lung cancer in real-world Spanish practice: a retrospective observational study (SILK study)
Characterization and economic burden of KRASG12C-mutant lung cancer in real-world Spanish practice: a retrospective observational study (SILK study) Open
These real-world data highlight the limited outcomes for most NSCLC patients with KRASG12C mutations, underscoring the significant clinical and economic burden associated with their care. The evaluation of the impact of novel and effective…
View article: Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer: Implications for Recurrence and Survival in Squamous Cell Carcinoma Patients
Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer: Implications for Recurrence and Survival in Squamous Cell Carcinoma Patients Open
Despite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, in early-stage cases, recurrence after surgery continues to be the pri…
View article: Corticosteroid and antimicrobial therapy in macrolide-resistant pneumococcal pneumonia porcine model
Corticosteroid and antimicrobial therapy in macrolide-resistant pneumococcal pneumonia porcine model Open
Background Streptococcus pneumoniae , a primary cause of community-acquired pneumonia (CAP), is typically treated with β-lactams and macrolides or quinolones. Corticosteroids are now recommended as adjunctive therapy in severe CAP to impro…
View article: Characterization and Economic Burden of Krasg12c-Mutant Lung Cancer in Real-World Spanish Practice: A Retrospective Observational Study (Silk Study)
Characterization and Economic Burden of Krasg12c-Mutant Lung Cancer in Real-World Spanish Practice: A Retrospective Observational Study (Silk Study) Open
View article: 20382. ETIOLOGÍA Y PRONÓSTICO DE UNA SERIE DE PACIENTES CON MONONEUROPATÍA DE IV NERVIO CRANEAL
20382. ETIOLOGÍA Y PRONÓSTICO DE UNA SERIE DE PACIENTES CON MONONEUROPATÍA DE IV NERVIO CRANEAL Open
View article: 20891. NEUROPATÍA ÓPTICA MIMICS: IDENTIFICACIÓN DE LAS CAUSAS MÁS FRECUENTES EN UNA SERIE DE CASOS
20891. NEUROPATÍA ÓPTICA MIMICS: IDENTIFICACIÓN DE LAS CAUSAS MÁS FRECUENTES EN UNA SERIE DE CASOS Open
View article: 20610. PSEUDO-MERALGIA PARESTÉSICA COMO FORMA DE PRESENTACIÓN DE SANGRADO ASOCIADO A CAVERNOMA MEDULAR DORSAL
20610. PSEUDO-MERALGIA PARESTÉSICA COMO FORMA DE PRESENTACIÓN DE SANGRADO ASOCIADO A CAVERNOMA MEDULAR DORSAL Open
View article: 20962. NEUROPATÍA ÓPTICA ISQUÉMICA ANTERIOR NO ARTERÍTICA, EXPERIENCIA DE UNA CONSULTA DE NEUROFTALMOLOGÍA
20962. NEUROPATÍA ÓPTICA ISQUÉMICA ANTERIOR NO ARTERÍTICA, EXPERIENCIA DE UNA CONSULTA DE NEUROFTALMOLOGÍA Open
View article: The genomic landscape of transformed splenic diffuse red pulp small B‐cell lymphoma
The genomic landscape of transformed splenic diffuse red pulp small B‐cell lymphoma Open
The genetic landscape underlying the transformation of splenic diffuse red pulp small B‐cell lymphoma (SDRPL) is not well understood. The present study aimed to unravel the genomic alterations involved in the progression and transformation…
View article: Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids
Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids Open
Introduction: Patient-derived organoids have emerged as a promising in vitro model for precision medicine, particularly in cancer, but also in noncancer-related diseases. However, the optimal culture medium for culturing patient-derived lu…
View article: Riqueza y abundancia de aves en el Parque Nacional La Sabana en época seca y lluviosa
Riqueza y abundancia de aves en el Parque Nacional La Sabana en época seca y lluviosa Open
Las aves son buenas indicadoras de la calidad ambiental pues su ocurrencia está determinada por las características del hábitat en que se encuentran y además son organismos que se avistan con relativa facilidad. La vegetación de La Sabana …
View article: Human senescent fibroblasts trigger progressive lung fibrosis in mice
Human senescent fibroblasts trigger progressive lung fibrosis in mice Open
Cell senescence has recently emerged as a potentially relevant pathogenic mechanism in fibrosing interstitial lung diseases (f-ILDs), particularly in idiopathic pulmonary fibrosis. We hypothesized that senescent human fibroblasts may suffi…
View article: Audiological benefit, quality of life, and factors associated with functional gain in elderly hearing aid users in a developing country between 2017 and 2020: a pre-post-study
Audiological benefit, quality of life, and factors associated with functional gain in elderly hearing aid users in a developing country between 2017 and 2020: a pre-post-study Open
Background Sensorineural hearing loss (SNHL) is the most common auditory deficit in older adults and may lead to quality-of-life deterioration. However, few studies have been performed in low/middle-income countries, particularly in Latin …
View article: A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury Open
View article: Data from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma
Data from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma Open
Neuroblastomas have neuroendocrine features and often show similar gene expression patterns to small cell lung cancer including high expression of delta-like ligand 3 (DLL3). Here we determine the efficacy of rovalpituzumab tesirine…
View article: Figures S1-7 from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma
Figures S1-7 from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma Open
Supplementary Figures 1-7 with legends included
View article: Data from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma
Data from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma Open
Neuroblastomas have neuroendocrine features and often show similar gene expression patterns to small cell lung cancer including high expression of delta-like ligand 3 (DLL3). Here we determine the efficacy of rovalpituzumab tesirine…
View article: Figures S1-7 from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma
Figures S1-7 from Evaluation of the DLL3-targeting Antibody–Drug Conjugate Rovalpituzumab Tesirine in Preclinical Models of Neuroblastoma Open
Supplementary Figures 1-7 with legends included
View article: Supplementary Figures 1-10; Supplemental Tables 1-6; and Supplemental Materials and Methods from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models
Supplementary Figures 1-10; Supplemental Tables 1-6; and Supplemental Materials and Methods from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models Open
SI Figure 1: Reaction scheme for synthesizing 1-(4-astatophenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one ([211At]MM4) from tin precursor 1-(4-(tributylstannyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; SI Figure…
View article: Data from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models
Data from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models Open
Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is a druggable protein in the nucleus th…
View article: Data from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models
Data from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models Open
Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is a druggable protein in the nucleus th…
View article: Data from Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma
Data from Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma Open
High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease…
View article: Data from Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma
Data from Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma Open
High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease…
View article: Supplementary Figures 1-10; Supplemental Tables 1-6; and Supplemental Materials and Methods from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models
Supplementary Figures 1-10; Supplemental Tables 1-6; and Supplemental Materials and Methods from Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models Open
SI Figure 1: Reaction scheme for synthesizing 1-(4-astatophenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one ([211At]MM4) from tin precursor 1-(4-(tributylstannyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; SI Figure…
View article: Supplementary Figure 3 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Supplementary Figure 3 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma Open
Supplementary Figure 3 - PDF file 127K, MYCN expression is inversely correlated with LEE011 sensitivity. (A) High mRNA expression of MYCN correlates with low LEE011 IC50s (r = -0.55, p = 0.02). This correlation is further strengthened (r =…