Daniel Pfeffer
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View article: Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation
Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation Open
Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome…
View article: PSAT095 Examination of Treatment Patterns in Patients with Classic Congenital Adrenal Hyperplasia (CAH) Compared to Treatment Guidelines
PSAT095 Examination of Treatment Patterns in Patients with Classic Congenital Adrenal Hyperplasia (CAH) Compared to Treatment Guidelines Open
Introduction Classic congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder, usually due to a deficiency in the 21-hydroxylase enzyme, that results in impaired cortisol synthesis and excess androgen production. Recomme…
View article: Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis
Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis Open
Low glucose-6-phosphate dehydrogenase enzyme (G6PD) activity is a key determinant of drug-induced haemolysis. More than 230 clinically relevant genetic variants have been described. We investigated the variation in G6PD activity within and…
View article: Characteristics of chronic intestinal failure in the USA based on analysis of claims data
Characteristics of chronic intestinal failure in the USA based on analysis of claims data Open
Background This study investigated the prevalence, characteristics, and management of patients with chronic intestinal failure (CIF) in the United States in 2012–2020, based on parenteral support (PS) prescription claims and healthcare uti…
View article: Repeatability and reproducibility of a handheld quantitative G6PD diagnostic
Repeatability and reproducibility of a handheld quantitative G6PD diagnostic Open
Background The introduction of novel short course treatment regimens for the radical cure of Plasmodium vivax requires reliable point-of-care diagnosis that can identify glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. While…
View article: Association of Drug Application and Hydration Status in Elderly Patients
Association of Drug Application and Hydration Status in Elderly Patients Open
Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. Mild cognitive impairment (MCI) or dementia increase the risk of dehydration and, in turn, dehydration …
View article: Correction: Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis
Correction: Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis Open
[This corrects the article DOI: 10.1371/journal.pmed.1003084.].
View article: Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis
Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis Open
Our findings indicate that there is substantial variation in G6PD measurements by spectrophotometry between sites. This is likely due to variability in laboratory methods, with possible contribution of unmeasured population factors. While …
View article: Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis
Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis Open
The CSG performed well at the 30% threshold. Its high NPV suggests that the test is suitable to guide PQ treatment, and the high LR+ and low LR- render the test suitable to confirm and exclude G6PDd. Further operational studies are needed …
View article: Quantifying the incidence of severe-febrile-illness hospital admissions in sub-Saharan Africa
Quantifying the incidence of severe-febrile-illness hospital admissions in sub-Saharan Africa Open
Severe-febrile-illness (SFI) is a common cause of morbidity and mortality across sub-Saharan Africa (SSA). The burden of SFI in SSA is currently unknown and its estimation is fraught with challenges. This is due to a lack of diagnostic cap…
View article: Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study
Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study Open
Bill & Melinda Gates Foundation.
View article: The contribution of non-malarial febrile illness co-infections to Plasmodium falciparum case counts in health facilities in sub-Saharan Africa
The contribution of non-malarial febrile illness co-infections to Plasmodium falciparum case counts in health facilities in sub-Saharan Africa Open
These findings highlight the complex nature of the P. falciparum burden amongst children under 5 years of age and indicate that for many children presenting at health clinics, a positive P. falciparum diagnosis and a fever does not necessa…
View article: Growing evidence of Plasmodium vivax across malaria-endemic Africa
Growing evidence of Plasmodium vivax across malaria-endemic Africa Open
Effective malaria control strategies require an accurate understanding of the epidemiology of locally transmitted Plasmodium species. Compared to Plasmodium falciparum infection, Plasmodium vivax has a lower asexual parasitaemia, forms dor…
View article: Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group Open
The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discus…
View article: MOESM1 of malariaAtlas: an R interface to global malariometric data hosted by the Malaria Atlas Project
MOESM1 of malariaAtlas: an R interface to global malariometric data hosted by the Malaria Atlas Project Open
Additional file 1. Illustrative R code used to conduct the Mock Analyses in this paper.
View article: An appraisal of practice guidelines for smoking cessation in people with severe mental illness
An appraisal of practice guidelines for smoking cessation in people with severe mental illness Open
Objective: To review the quality of current smoking cessation guidelines that include recommendations for people with severe mental illness. Methods: A systematic search of scientific databases, central government health authority websites…
View article: Smokers’ Understandings of Addiction to Nicotine and Tobacco: A Systematic Review and Interpretive Synthesis of Quantitative and Qualitative Research
Smokers’ Understandings of Addiction to Nicotine and Tobacco: A Systematic Review and Interpretive Synthesis of Quantitative and Qualitative Research Open
Quantitative studies show that most smokers believe that smoking is addictive and that they are addicted. A feeling of "need" for cigarettes was central to qualitative accounts of addiction, but nicotine was not often discussed. Overall, s…