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View article: Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior
Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior Open
In various organisms, sequencing of selectively bred lines at apparent selection limits has demonstrated that genetic variation can remain at many loci, implying that evolution at the genetic level may continue even if the population mean …
View article: Obesity genes: So close and yet so far...
Obesity genes: So close and yet so far... Open
Little is known about genetic variants that predispose individuals toward leanness or fatness. This minireview highlights recent advances in the study of human populations, animal models and synergistic efforts as described by De Luca and …
View article: Genetic architecture of voluntary exercise in an advanced intercross line of mice
Genetic architecture of voluntary exercise in an advanced intercross line of mice Open
Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in is strikingly variable, even under prescription. Our focus was to identify the locations and effects of quantitative trait loci (QTL) cont…
View article: Advances in comparative genetics: influence of genetics on obesity
Advances in comparative genetics: influence of genetics on obesity Open
Obesity has reached epidemic proportions and is recognised as a significant global health problem. Increased food intake and decreased physical activity are traditionally to blame for the development of obesity; however, many variables suc…
View article: Genetic architecture modulates diet-induced hepatic mRNA and miRNA expression profiles in Diversity Outbred mice
Genetic architecture modulates diet-induced hepatic mRNA and miRNA expression profiles in Diversity Outbred mice Open
Genetic approaches in model organisms have consistently demonstrated that molecular traits such as gene expression are under genetic regulation, similar to clinical traits. The resulting expression quantitative trait loci (eQTL) have revol…
View article: Genetic determinants of voluntary exercise
Genetic determinants of voluntary exercise Open
Variation in voluntary exercise behavior is an important determinant of long-term human health. Increased physical activity is used as a preventative measure or therapeutic intervention for disease, and a sedentary lifestyle has generally …
View article: Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength Open
This data repository contains data in support of "Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength". The following data are included: Raw genotyping results using the GigaMUGA array for …
View article: Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength Open
This data repository contains data in support of "Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength". The following data are included: Raw genotyping results using the GigaMUGA array for …
View article: Quantitative trait loci for physical activity traits in mice
Quantitative trait loci for physical activity traits in mice Open
The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel dis…
View article: Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss
Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss Open
Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate …
View article: Identification of quantitative trait loci influencing skeletal architecture in mice: Emergence of Cdh11 as a primary candidate gene regulating femoral morphology
Identification of quantitative trait loci influencing skeletal architecture in mice: Emergence of Cdh11 as a primary candidate gene regulating femoral morphology Open
Bone strength is influenced by many properties intrinsic to bone, including its mass, geometry, and mineralization. To further advance our understanding of the genetic basis of bone strength-related traits, we utilized a large (N=815), mod…
View article: High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis
High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis Open
Inbred mice exhibit strain-specific variation in susceptibility to atherosclerosis and dyslipidemia that renders them useful in dissecting the genetic architecture of these complex diseases. Traditional quantitative trait locus (QTL) mappi…
View article: Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors
Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors Open
BackgroundIncreased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands.ObjectivesWe investigated the consequences of high-fat diet …
View article: Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice
Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice Open
BackgroundIndividuality in the species composition of the vertebrate gut microbiota is driven by a combination of host and environmental factors that have largely been studied independently. We studied the convergence of these factors in a…
View article: The use of plasmodes as a supplement to simulations: A simple example evaluating individual admixture estimation methodologies
The use of plasmodes as a supplement to simulations: A simple example evaluating individual admixture estimation methodologies Open
With the advent of powerful computers, simulation studies are becoming an important tool in statistical methodology research. However, computer simulations of a specific process are only as good as our understanding of the underlying mecha…
View article: Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity
Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity Open
Dysregulation of the dopamine system is linked to various aberrant behaviors, including addiction, compulsive exercise, and hyperphagia leading to obesity. The goal of the present experiments was to determine how dopamine contributes to th…
View article: Applying functional genomics research to the study of pig reproduction
Applying functional genomics research to the study of pig reproduction Open
Functional genomics is an experimental approach that incorporates genomewide or system-wide experimentation, expanding the scope of biological investigation from studying single genes to studying potentially all genes at once in a systemat…
View article: Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice
Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice Open
House mice from 4 replicate lines selectively bred for 61 generations for voluntary wheel-running behavior were compared with 4 non-selected control lines using multiple genome-wide analytical techniques on both haplotype and single nucleo…
View article: RETRACTED: Genetic Architecture Modulates Diet-Induced Hepatic mRNA and miRNA Expression Profiles in Diversity Outbred Mice
RETRACTED: Genetic Architecture Modulates Diet-Induced Hepatic mRNA and miRNA Expression Profiles in Diversity Outbred Mice Open
Genetic approaches in model organisms have consistently demonstrated that molecular traits such as gene expression are under genetic regulation, similar to clinical traits. The resulting expression quantitative trait loci (eQTL) have revol…
View article: Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify<i>Qsox1</i>as a novel determinant of bone strength
Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify<i>Qsox1</i>as a novel determinant of bone strength Open
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BM…
View article: Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes
Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes Open
The biology of how faces are built and come to differ from one another is complex. Discovering normal variants that contribute to differences in facial morphology is one key to untangling this complexity, with important implications for me…
View article: Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure
Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure Open
Among cancer diagnoses, colorectal cancer (CRC) is prevalent, with a lifetime risk of developing CRC being approximately 5%. Population variation surrounding the mean risk of developing CRCs has been associated with both inter-individual d…
View article: Improving Metabolic Health Through Precision Dietetics in Mice
Improving Metabolic Health Through Precision Dietetics in Mice Open
The incidence of diet-induced metabolic disease has soared over the last half-century, despite national efforts to improve health through universal dietary recommendations. Studies comparing dietary patterns of populations with health outc…
View article: Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes
Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes Open
The biology of how faces are built and come to differ from one another is complex. Discovering the genes that contribute to differences in facial morphology is one key to untangling this complexity, with important implications for medicine…
View article: A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice Open
Background In recent years it has become increasingly apparent that physical inactivity can predispose individuals to a host of health problems. While many studies have analyzed the effect of various environmental factors on activity, we k…
View article: Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data
Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data Open
Background To understand the genetic architecture of complex traits and bridge the genotype-phenotype gap, it is useful to study intermediate -omics data, e.g. the transcriptome. The present study introduces a method for simultaneous quant…
View article: Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice
Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice Open
Background The genome, the environment, and their interactions simultaneously regulate complex traits such as body composition and voluntary exercise levels. One such environmental influence is the maternal milieu (i.e., in utero environme…
View article: Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease
Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease Open
Background Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues, resulting in an energy imbalance at t…
View article: Genetic variation in the pleiotropic association between physical activity and body weight in mice
Genetic variation in the pleiotropic association between physical activity and body weight in mice Open
Background A sedentary lifestyle is often assumed to lead to increases in body weight and potentially obesity and related diseases but in fact little is known about the genetic association between physical activity and body weight. We test…