Daniel Postrach
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View article: Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development Open
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with computational inference, we comprehensively…
View article: Polytope: High-resolution epitope barcoding for<i>in vivo</i>spatial fate-mapping
Polytope: High-resolution epitope barcoding for<i>in vivo</i>spatial fate-mapping Open
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-based fate-mapping provides spatial information, it generally lacks complexity due to limited label diversity, resulting in diminished capture…
View article: Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer Open
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenograf…