Daniel Z. Press
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View article: An optimized cognitive biomarker that accurately predicts future cognitive decline and improves the detection of MCI and early dementia
An optimized cognitive biomarker that accurately predicts future cognitive decline and improves the detection of MCI and early dementia Open
Background Mild Cognitive Impairment (MCI) affects over 12 million individuals in the US, 50% of whom will progress to Alzheimer's disease or another form of dementia in 3‐5 years. But 90% of individuals with MCI remain undiagnosed due to …
View article: Input‐output curve reveals slope of cortical hyperexcitability in early Alzheimer’s disease
Input‐output curve reveals slope of cortical hyperexcitability in early Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is linked to abnormal cortical excitability. Recent studies have suggested that amyloid‐related cortical hyperexcitability may drive faster clinical decline and be related to spreading of tau. However, w…
View article: Limitations and Potential Improvement of Cognitive Screening Tests for Mild Cognitive Impairment
Limitations and Potential Improvement of Cognitive Screening Tests for Mild Cognitive Impairment Open
Background Mild cognitive impairment (MCI), an early sign of Alzheimer's Disease (AD), involves disruptions in both memory and cognition. Early and accurate detection of MCI is critical, as recently FDA approved disease modifying treatment…
View article: Development of an at‐home cognitive “vital sign” to detect cognitive changes in Alzheimer's disease
Development of an at‐home cognitive “vital sign” to detect cognitive changes in Alzheimer's disease Open
Background Patients with Early Alzheimer's Disease (AD) can have fluctuations in their cognitive abilities. A rapid, significant change could indicate a serious health condition ranging from a urinary tract infection to delirium from brain…
View article: Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer’s disease
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer’s disease Open
Neural hyperexcitability and network dysfunction are neurophysiological hallmarks of Alzheimer’s disease (AD) in animal studies, but their presence and clinical relevance in humans remain poorly understood. We introduce a perturbation-base…
View article: Transcriptomic analyses of human brains with Alzheimer’s disease identified dysregulated epilepsy-causing genes
Transcriptomic analyses of human brains with Alzheimer’s disease identified dysregulated epilepsy-causing genes Open
Background & Objective Alzheimer’s Disease (AD) patients at multiple stages of disease progression have a high prevalence of seizures. However, whether AD and epilepsy share pathophysiological changes remains poorly defined. In this study,…
View article: TMS‐EEG excitability measures are related to global and local cognitive function in early symptomatic AD
TMS‐EEG excitability measures are related to global and local cognitive function in early symptomatic AD Open
Background Cortical excitability is elevated in Alzheimer’s disease (AD). Transcranial magnetic stimulation‐evoked responses on electromyography (EMG) and electroencephalography (EEG) have captured this increased excitability in motor brai…
View article: A prospective study of a rapid adaptive version of the Boston Naming Test for Alzheimer’s disease
A prospective study of a rapid adaptive version of the Boston Naming Test for Alzheimer’s disease Open
Background Cognitive tests of naming ability have been shown to have diagnostic and prognostic utility in both mild cognitive impairment (MCI) and Alzheimer’s disease (AD; Taler & Phillips, 2008). The Boston Naming Test (BNT) is the most c…
View article: Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer’s disease
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer’s disease Open
Neural hyper-excitability and network dysfunction are neurophysiological hallmarks of Alzheimer’s disease (AD) in animal studies, but their presence and clinical relevance in humans remain poorly understood. We introduce a novel perturbati…
View article: Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow
Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow Open
Background In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discharges and a study us…
View article: Enhancing Efficiency with an AI-Augmented Clinician in Neurology
Enhancing Efficiency with an AI-Augmented Clinician in Neurology Open
Integrating artificial intelligence (AI) technologies into neurology promises increased patient access, engagement, and quality of care, as well as improved quality of work life for clinicians. While most studies have focused on comparing …
View article: Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations
Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations Open
Functional MRI methods can assess aspects of drug-induced brain response. Resting blood oxygenation level dependent (BOLD) fMRI and arterial spin labeling (ASL) perfusion MRI indirectly measure brain function through the coupling of activi…
View article: TMS‐based measures of cortical excitability are related to distributed atrophy in early Alzheimer’s disease
TMS‐based measures of cortical excitability are related to distributed atrophy in early Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is associated with increased cortical excitability, including an elevated risk of seizures. Transcranial magnetic stimulation with electromyography (TMS‐EMG‐EEG) can be used to index intracortical excita…
View article: Developing a brief, accurate and adaptive version of the Boston Naming Test based on high‐fidelity estimates of item properties
Developing a brief, accurate and adaptive version of the Boston Naming Test based on high‐fidelity estimates of item properties Open
Background Current naming tests such as the Boston Naming Test (BNT) and the Multilingual Naming Test have demonstrated significant clinical utility in detecting naming deficits in mild cognitive impairment (MCI), assisting with differenti…
View article: Transcranial Magnetic Stimulation based Network Integrity Assessment in Alzheimer’s disease
Transcranial Magnetic Stimulation based Network Integrity Assessment in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) has a relatively well‐characterized pathology of amyloid‐β and tau accumulation. Yet, disease progression from preclinical to clinical stage remains largely unpredictable at the individual level. Growing…
View article: A study of flex miniaturized coils for focal nerve magnetic stimulation
A study of flex miniaturized coils for focal nerve magnetic stimulation Open
Background Peripheral magnetic stimulation (PMS) is emerging as a complement to standard electrical stimulation (ES) of the peripheral nervous system (PNS). PMS may stimulate sensory and motor nerve fibers without the discomfort associated…
View article: In Older Adults the Antidepressant Effect of Repetitive Transcranial Magnetic Stimulation Is Similar but Occurs Later Than in Younger Adults
In Older Adults the Antidepressant Effect of Repetitive Transcranial Magnetic Stimulation Is Similar but Occurs Later Than in Younger Adults Open
Background Treatment resistant depression is common in older adults and treatment is often complicated by medical comorbidities and polypharmacy. Repetitive transcranial magnetic stimulation (rTMS) is a treatment option for this group due …
View article: Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series Open
Background: Alzheimer’s disease (AD) is characterized by diffuse amyloid-β (Aβ) and phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced 40 Hz gamma oscillations have been showing to reduce Aβ and p-Tau d…
View article: Reply: Variability in motor threshold
Reply: Variability in motor threshold Open
Funding Information: GC was funded by Funda??o para a Ci?ncia e Tecnologia (FCT; Portugal) through a PhD Scholarship (SFRH/BD/130210/2017). AJO-M was funded by FCT (Portugal) through a Junior Research and Career Development Award from the …
View article: Screening of Parkinson’s Disease Using Geometric Features Extracted from Spiral Drawings
Screening of Parkinson’s Disease Using Geometric Features Extracted from Spiral Drawings Open
Conventional means of Parkinson’s Disease (PD) screening rely on qualitative tests typically administered by trained neurologists. Tablet technologies that enable data collection during handwriting and drawing tasks may provide low-cost, p…
View article: Diagnosis and Workup of Intellectual Disability in Adults
Diagnosis and Workup of Intellectual Disability in Adults Open
Specific diagnoses may help guide management and surveillance of comorbid conditions in individuals with ID. Etiologic investigations of adults with ID include genetic and metabolic testing and brain imaging in the appropriate clinical set…