Daniel R. Getts
YOU?
Author Swipe
View article: 1342 First-in-human dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and initial efficacy of mRNA-LNP MT-302 <i>in vivo</i> CAR therapy in solid tumors
1342 First-in-human dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and initial efficacy of mRNA-LNP MT-302 <i>in vivo</i> CAR therapy in solid tumors Open
View article: CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery
CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery Open
View article: In vivo programmed myeloid cells expressing novel chimeric antigen receptors show potent anti-tumor activity in preclinical solid tumor models
In vivo programmed myeloid cells expressing novel chimeric antigen receptors show potent anti-tumor activity in preclinical solid tumor models Open
Introduction The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of B cell malignancies has fueled the development of numerous ex vivo cell therapies. However, these cell therapies are complex and costly, and…
View article: CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery
CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery Open
To address a wide range of genetic diseases, genome editing tools that can achieve targeted delivery of large genes without causing double-stand breaks (DSBs) or requiring DNA templates are necessary. Here, we introduce the CRISPR-Enabled …
View article: Chimeric Antigen Cytotoxic Receptors for In Vivo Engineering of Tumor-Targeting NK Cells
Chimeric Antigen Cytotoxic Receptors for In Vivo Engineering of Tumor-Targeting NK Cells Open
Chimeric Ag receptor (CAR) NK cells are challenging to manufacture and fail to achieve consistent tumor infiltration and sustained cytolytic function in the tumor microenvironment. In vivo engineering of NK cells using mRNA-based CAR deliv…
View article: Chimeric Antigen Cytotoxic Receptors for In-Vivo Engineering of Tumor-targeting Natural Killer Cells
Chimeric Antigen Cytotoxic Receptors for In-Vivo Engineering of Tumor-targeting Natural Killer Cells Open
Ex vivo chimeric antigen receptor (CAR) NK cells face challenges in manufacturing, and have limited tumor infiltration and in vivo persistency. A method leveraging mRNA-based delivery for in-vivo engineering of human NK cells could address…
View article: Immune Modifying Effect of Drug Free Biodegradable Nanoparticles on Disease Course of Experimental Autoimmune Neuritis
Immune Modifying Effect of Drug Free Biodegradable Nanoparticles on Disease Course of Experimental Autoimmune Neuritis Open
Guillain-Barré Syndrome (GBS) is an autoimmune disease of demyelination and inflammation of peripheral nerves. Current treatments are limited to plasma exchange and intravenous immunoglobulins. Cargo-free nanoparticles (NPs) have been eval…
View article: 1237 In vivo programming of myeloid cells by mRNA mediated delivery of novel Fca fusion receptor activates anti-tumor immunity
1237 In vivo programming of myeloid cells by mRNA mediated delivery of novel Fca fusion receptor activates anti-tumor immunity Open
Background Immunotherapy has revolutionized cancer treatment. However, for the majority of patients with advanced solid tumors, sustained clinical benefit has yet to be achieved. Myeloid cells such as monocytes and macrophages readily accu…
View article: 393 ATAK receptors, a new class of chimeric antigen receptor that harness innate immunity in myeloid cells to target cancer
393 ATAK receptors, a new class of chimeric antigen receptor that harness innate immunity in myeloid cells to target cancer Open
Background For the majority of patients with advanced solid tumors, sustained clinical benefit with immunotherapy has yet to be achieved. Myeloid cells, including monocytes and macrophages are the primary orchestrators of immune responses …
View article: MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 Model
MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 Model Open
View article: Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model
Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model Open
View article: TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study
TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study Open
View article: Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease Open
View article: Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX <sub>3</sub> CR1 <sup>+</sup> Macrophages in Tissue Repair
Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX <sub>3</sub> CR1 <sup>+</sup> Macrophages in Tissue Repair Open
Arthritogenic alphaviruses cause debilitating inflammatory disease, and current therapies are restricted to palliative approaches. Here, we show that following monocyte-driven muscle inflammation, tissue recovery is associated with the acc…
View article: Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response Open
View article: Experimental severe malaria is resolved by targeting newly-identified monocyte subsets using immune-modifying particles combined with artesunate
Experimental severe malaria is resolved by targeting newly-identified monocyte subsets using immune-modifying particles combined with artesunate Open
Current treatment of severe malaria and associated cerebral malaria (CM) and respiratory distress syndromes are directed primarily at the parasite. Targeting the parasite has only partial efficacy in advanced infection, as neurological dam…
View article: Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates
Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates Open
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-specific immunological tolerance in multiple immune models and are at various stages of commercial development. Association of Ag with NPs is typically …
View article: Harnessing Nanoparticles for Immune Modulation
Harnessing Nanoparticles for Immune Modulation Open
View article: Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization
Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization Open
Significance Allergic diseases are characterized by inappropriate inflammatory responses to benign environmental antigens (Ags). Primary clinical approaches to allergic disease consist of symptom control or administration of soluble Ag to …
View article: Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity Open
The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with “environmental” factors, including viral infection, leading to disease. One elegant animal model …
View article: Harnessing nanoparticles for immune modulation
Harnessing nanoparticles for immune modulation Open